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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: EPS15

Summary

GeneID

2060

Symbol

EPS15

Synonyms

AF-1P|AF1P|MLLT5

Description

epidermal growth factor receptor pathway substrate 15

Locus tag

Gene type

protein-coding

Map location

1p32

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.014

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005509

calcium ion binding

IEA

GO:0005515

protein binding

IPI

10613896

GO:0017124

SH3 domain binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007173

epidermal growth factor receptor signaling pathway

TAS

8183552

GO:0016050

vesicle organization

TAS

9762922

GO:0008283

cell proliferation

TAS

8183552

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005829

cytosol

EXP

10567358 |12218189 |15962011

GO:0005737

cytoplasm

IEA

GO:0005905

coated pit

TAS

9762922

GO:0005886

plasma membrane

IDA

15465819

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AGFG1	DKFZp686I15205 \| HRB \| MGC116938 \| MGC116940 \| RAB \| RIP	ArfGAP with FG repeats 1	The EH domain of Eps15 interacts with the NPF motif of RAB.	BIND	9303539
			Affinity Capture-Western Co-fractionation Phenotypic Enhancement Two-hybrid	BioGRID	10613896
			-	HPRD	9303539
AGFG2	HRBL \| RABR	ArfGAP with FG repeats 2	The EH domain of Eps15 interacts with the NPF motif of RAB-R. This interaction was modeled on a demonstrated interaction between mouse Eps15 and human RAB-R.	BIND	9303539
AGFG2	HRBL \| RABR	ArfGAP with FG repeats 2	Co-fractionation	BioGRID	10613896
AP2A1	ADTAA \| AP2-ALPHA \| CLAPA1	adaptor-related protein complex 2, alpha 1 subunit	-	HPRD,BioGRID	8662627\|9049247
AP2A2	ADTAB \| CLAPA2 \| HIP9 \| HYPJ	adaptor-related protein complex 2, alpha 2 subunit	-	HPRD	9049247
AP2A2	ADTAB \| CLAPA2 \| HIP9 \| HYPJ	adaptor-related protein complex 2, alpha 2 subunit	Reconstituted Complex	BioGRID	10809762
CDC40	EHB3 \| FLJ10564 \| MGC102802 \| PRP17 \| PRPF17	cell division cycle 40 homolog (S. cerevisiae)	The EH domain of Eps15 interacts with the NPF motif of ehb3. This interaction was modeled on a demonstrated interaction between mouse Eps15 and human ehb3.	BIND	9303539
CLINT1	CLINT \| ENTH \| EPN4 \| EPNR \| EPSINR \| FLJ46753 \| KIAA0171	clathrin interactor 1	Reconstituted Complex	BioGRID	12429846
CRK	CRKII	v-crk sarcoma virus CT10 oncogene homolog (avian)	-	HPRD,BioGRID	7797522
DNM1	DNM	dynamin 1	-	HPRD	11483962
DNM2	CMTDI1 \| CMTDIB \| DI-CMTB \| DYN2 \| DYNII	dynamin 2	-	HPRD,BioGRID	11483962
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	-	HPRD,BioGRID	9049247
ELF3	EPR-1 \| ERT \| ESE-1 \| ESX	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	-	HPRD	10064583
EPN1	-	epsin 1	-	HPRD,BioGRID	9723620
EPN2	EHB21 \| KIAA1065	epsin 2	in vivo	BioGRID	10567358
			The EH domain of Eps15 interacts with the NPF motif of ehb21, isoform b. This interaction was modeled on a demonstrated interaction between mouse Eps15 and human ehb21, isoform b.	BIND	9303539
			The EH domain of Eps15 interacts with the NPF motif of ehb21, isoform a. This interaction was modeled on a demonstrated interaction between mouse Eps15 and human ehb21, isoform a.	BIND	9303539
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	Far Western	BioGRID	7797522
HGS	HRS \| ZFYVE8	hepatocyte growth factor-regulated tyrosine kinase substrate	-	HPRD,BioGRID	12551915
NAGPA	APAA \| UCE	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase	-	HPRD,BioGRID	11723124
NEDD4	KIAA0093 \| MGC176705 \| NEDD4-1 \| RPF1	neural precursor cell expressed, developmentally down-regulated 4	-	HPRD,BioGRID	11919637
NUMB	S171	numb homolog (Drosophila)	The EH domain of Eps15 interacts with the NPF motif of NUMB.	BIND	9303539
NUMB	S171	numb homolog (Drosophila)	-	HPRD	9303539
NUMBL	CAG3A \| CTG3a \| NBL \| NUMB-R \| NUMBLIKE \| NUMBR \| TNRC23	numb homolog (Drosophila)-like	The EH domain of Eps15 interacts with the NPF motif of NUMB-R. This interaction was modeled on a demonstrated interaction between mouse Eps15 and human NUMB-R.	BIND	9303539
RAB11FIP2	KIAA0941 \| Rab11-FIP2 \| nRip11	RAB11 family interacting protein 2 (class I)	Affinity Capture-Western	BioGRID	12364336
REPS2	POB1	RALBP1 associated Eps domain containing 2	-	HPRD,BioGRID	10393179
RNF11	CGI-123 \| MGC51169 \| SID1669	ring finger protein 11	Two-hybrid	BioGRID	14755250
RNF11	CGI-123 \| MGC51169 \| SID1669	ring finger protein 11	RNF11 interacts with EPS15.	BIND	14755250
SCAMP1	SCAMP \| SCAMP37	secretory carrier membrane protein 1	Two-hybrid	BioGRID	10777571
SH3BP4	BOG25 \| TTP	SH3-domain binding protein 4	The EH domain of Eps15 interacts with the NPF motif of ehb10. This interaction was modeled on a demonstrated interaction between mouse Eps15 and human ehb10.	BIND	9303539
SNAP91	AP180 \| CALM \| DKFZp781O0519 \| KIAA0656	synaptosomal-associated protein, 91kDa homolog (mouse)	-	HPRD,BioGRID	12807910
STAM	DKFZp686J2352 \| STAM1	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	-	HPRD	12551915
STAM2	DKFZp564C047 \| Hbp \| STAM2A \| STAM2B	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2	-	HPRD,BioGRID	12551915
STON2	STN2 \| STNB \| STNB2	stonin 2	-	HPRD,BioGRID	11381094

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-130/301	1781	1787	m8	hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
miR-148/152	1782	1788	m8	hsa-miR-148a	UCAGUGCACUACAGAACUUUGU
				hsa-miR-152^brain	UCAGUGCAUGACAGAACUUGGG
				hsa-miR-148b	UCAGUGCAUCACAGAACUUUGU
miR-181	2031	2037	m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-19	1780	1786	m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	1780	1786	m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-196	77	83	m8	hsa-miR-196a	UAGGUAGUUUCAUGUUGUUGG
miR-196	77	83	m8	hsa-miR-196b	UAGGUAGUUUCCUGUUGUUGG
miR-23	121	127	m8	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	121	127	m8	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-26	1764	1770	1A	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	1764	1770	1A	hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-29	1477	1483	m8	hsa-miR-29a^SZ	UAGCACCAUCUGAAAUCGGUU
				hsa-miR-29b^SZ	UAGCACCAUUUGAAAUCAGUGUU
				hsa-miR-29c^SZ	UAGCACCAUUUGAAAUCGGU
miR-323	121	127	1A	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-495	1937	1943	1A	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.