Gene Page: CUL2

Summary
GeneID  8453
Symbol  CUL2
Synonyms  MGC131970
Description  cullin 2
See related  HGNC:2552|MIM:603135|Ensembl:ENSG00000108094|HPRD:06786|
Locus tag  -
Gene type  protein-coding
Map location  10p11.21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0312 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
IFI350.940.90
OASL0.940.82
OAS10.930.78
IFI60.920.80
ISG150.900.78
BST20.900.87
PSMB80.890.88
IFITM30.860.93
TAP10.840.77
MT1E0.840.88
Top 10 negatively co-expressed genes
DDX42-0.59-0.76
ABCF1-0.58-0.75
ARFGAP1-0.58-0.66
GGNBP2-0.58-0.76
USP7-0.58-0.76
SFRS14-0.58-0.81
CCDC49-0.58-0.83
C14orf102-0.57-0.74
SF3B2-0.57-0.81
PELP1-0.57-0.78
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI12609982 |17353931 
GO:0031625ubiquitin protein ligase bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000082G1/S transition of mitotic cell cycleTAS8681378 
GO:0006511ubiquitin-dependent protein catabolic processIEA-
GO:0007050cell cycle arrestTAS8681378 
GO:0008285negative regulation of cell proliferationTAS8681378 
GO:0008629induction of apoptosis by intracellular signalsTAS8681378 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0031461cullin-RING ubiquitin ligase complexIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CAB39CGI-66 | FLJ22682 | MO25calcium binding protein 39Affinity Capture-MSBioGRID17353931 
CAND1DKFZp434M1414 | FLJ10114 | FLJ10929 | FLJ38691 | FLJ90441 | KIAA0829 | TIP120 | TIP120Acullin-associated and neddylation-dissociated 1Affinity Capture-MS
Affinity Capture-Western		BioGRID12609982 
CMBLFLJ23617carboxymethylenebutenolidase homolog (Pseudomonas)Affinity Capture-MSBioGRID17353931 
DLG3KIAA1232 | MRX | MRX90 | NE-Dlg | NEDLG | SAP102discs, large homolog 3 (neuroendocrine-dlg, Drosophila)Affinity Capture-MSBioGRID17353931 
GPS1COPS1 | CSN1 | MGC71287G protein pathway suppressor 1-HPRD11337588 
KCTD5FLJ20040potassium channel tetramerisation domain containing 5Affinity Capture-MSBioGRID17353931 
P4HBDSI | ERBA2L | GIT | PDI | PDIA1 | PHDB | PO4DB | PO4HB | PROHBprocollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptideAffinity Capture-MSBioGRID17353931 
PFKFB3IPFK2 | PFK26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3Affinity Capture-MSBioGRID17353931 
RBX1BA554C12.1 | MGC13357 | MGC1481 | RNF75 | ROC1ring-box 1Affinity Capture-MSBioGRID12481031 
RNF7CKBBP1 | ROC2 | SAGring finger protein 7-HPRD,BioGRID10230407 
RNMTL1FLJ10581 | HC90RNA methyltransferase like 1Affinity Capture-MSBioGRID17353931 
STOMBND7 | EPB7 | EPB72stomatinAffinity Capture-MSBioGRID17353931 
TCEB1SIIItranscription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)Reconstituted ComplexBioGRID11384984 
TCEB2ELOB | SIIItranscription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)Reconstituted ComplexBioGRID11384984 
TFE3RCCP2 | TFEA | bHLHe33transcription factor binding to IGHM enhancer 3Affinity Capture-MSBioGRID17353931 
TIMM13TIM13 | TIM13B | TIMM13A | TIMM13B | ppv1translocase of inner mitochondrial membrane 13 homolog (yeast)Affinity Capture-MSBioGRID17353931 
VHLHRCA1 | RCA1 | VHL1von Hippel-Lindau tumor suppressorAffinity Capture-MS
Affinity Capture-Western
Reconstituted Complex		BioGRID10587522 |11384984 
|17353931 
hCG_1983332LOC441246hCG1983332Affinity Capture-MSBioGRID17353931 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 13898All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_RENAL_CELL_CARCINOMA 7060All SZGR genes in this pathway
PID_HIF1A_PATHWAY 1912All SZGR genes in this pathway
REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN 2517All SZGR genes in this pathway
REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA 1812All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 251156All SZGR genes in this pathway
REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION 212129All SZGR genes in this pathway
BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_UP 206111All SZGR genes in this pathway
GARY_CD5_TARGETS_DN 431263All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN 320184All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_UP 557331All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_UP 584356All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_XPCS_DN 8871All SZGR genes in this pathway
MIDORIKAWA_AMPLIFIED_IN_LIVER_CANCER 5538All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_6 8454All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
LIANG_HEMATOPOIESIS_STEM_CELL_NUMBER_LARGE_VS_TINY_DN 4524All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
LOCKWOOD_AMPLIFIED_IN_LUNG_CANCER 214139All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP 424268All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
KAMMINGA_EZH2_TARGETS 4126All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR 532309All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
YAMAZAKI_TCEB3_TARGETS_DN 215132All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_DN 165106All SZGR genes in this pathway
HEDENFALK_BREAST_CANCER_BRCA1_VS_BRCA2 163113All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP 863514All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_UP 518299All SZGR genes in this pathway
SAKAI_CHRONIC_HEPATITIS_VS_LIVER_CANCER_UP 8363All SZGR genes in this pathway
KYNG_WERNER_SYNDROM_AND_NORMAL_AGING_DN 225124All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-142-5p210216m8hsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
miR-15/16/195/424/497417423m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-30-5p1211281A,m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.