Gene Page: ABL2

Summary
GeneID  27
Symbol  ABL2
Synonyms  ABLL|ARG|FLJ22224|FLJ31718|FLJ41441
Description  v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)
See related  HGNC:77|MIM:164690|Ensembl:ENSG00000143322|HPRD:01259|
Locus tag  RP11-177A2.3
Gene type  protein-coding
Map location  1q24-q25
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0114 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PYCR20.770.80
SIL10.740.75
DNPEP0.740.72
ACO20.710.73
COQ90.710.70
CD810.700.73
NDUFAF30.700.70
NINJ10.700.71
HS1BP30.690.70
ENO10.690.68
Top 10 negatively co-expressed genes
FAM159B-0.42-0.52
EIF5B-0.40-0.45
ANKRD12-0.39-0.35
PHF14-0.36-0.36
THOC2-0.36-0.35
KIAA2022-0.35-0.20
WNK3-0.34-0.16
AC016138.1-0.34-0.23
SEC62-0.34-0.31
CEP170-0.34-0.16
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000287magnesium ion bindingIDA15886098 
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI15886098 
GO:0005524ATP bindingIEA-
GO:0004713protein tyrosine kinase activityIEA-
GO:0004715non-membrane spanning protein tyrosine kinase activityIEA-
GO:0016740transferase activityIEA-
GO:0035014phosphoinositide 3-kinase regulator activityIEA-
GO:0030145manganese ion bindingIDA15886098 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007155cell adhesionIEA-
GO:0006464protein modification processTAS2198571 
GO:0006468protein amino acid phosphorylationIEA-
GO:0007165signal transductionTAS2198571 
GO:0018108peptidyl-tyrosine phosphorylationIDA15886098 
GO:0051353positive regulation of oxidoreductase activityIDA12893824 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005856cytoskeletonIEA-
GO:0005737cytoplasmIEA-
GO:0005942phosphoinositide 3-kinase complexIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinase-HPRD,BioGRID12569093 
ABL1 (c-Abl) phosphorylates ABL2 (Arg).BIND15735735 
c-Abl interacts with ARG.BIND1383690 
ABL2ABLL | ARG | FLJ22224 | FLJ31718 | FLJ41441v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)ABL2 (Arg) is an autophosphorylating molecule.BIND15735735 
BCRALL | BCR-ABL1 | BCR1 | CML | D22S11 | D22S662 | FLJ16453 | PHLbreakpoint cluster regionBCR interacts with ARG. This interaction was modeled on a demonstrated interaction between BCR from an unspecified source and human ARG.BIND1383690 
CATMGC138422 | MGC138424catalase-HPRD,BioGRID12777400 
CRKCRKIIv-crk sarcoma virus CT10 oncogene homolog (avian)Abl2 phosphorylates CRK. This interaction was modeled on a demonstrated interaction between ABL2 from an unspecified species and human CRK.BIND15886098 
-HPRD8875975 
ABL2 (Arg) phosphorylates CRK.BIND15735735 
GPX1GSHPX1 | MGC14399 | MGC88245glutathione peroxidase 1-HPRD12893824 
HCKJTK9hemopoietic cell kinase-HPRD12748290 
JAK1JAK1A | JAK1B | JTK3Janus kinase 1 (a protein tyrosine kinase)Affinity Capture-WesternBioGRID9774693 
RIN1-Ras and Rab interactor 1ABL2 interacts with and phosphorylates RIN1.BIND15886098 
SORBS2ARGBP2 | FLJ93447 | KIAA0777 | PRO0618sorbin and SH3 domain containing 2-HPRD,BioGRID9211900 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ERBB_SIGNALING_PATHWAY 8771All SZGR genes in this pathway
KEGG_VIRAL_MYOCARDITIS 7358All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE 251188All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ROBO_RECEPTOR 3026All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_DN 406230All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_MAGENTA_UP 2818All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP 544308All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LPS_UP 431237All SZGR genes in this pathway
MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_17 2512All SZGR genes in this pathway
SHI_SPARC_TARGETS_UP 2417All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
POMEROY_MEDULLOBLASTOMA_DESMOPLASIC_VS_CLASSIC_UP 6238All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR 532309All SZGR genes in this pathway
CHANG_IMMORTALIZED_BY_HPV31_UP 8455All SZGR genes in this pathway
BILD_MYC_ONCOGENIC_SIGNATURE 206117All SZGR genes in this pathway
CHO_NR4A1_TARGETS 3322All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN 784464All SZGR genes in this pathway
ROESSLER_LIVER_CANCER_METASTASIS_UP 10772All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF 516308All SZGR genes in this pathway


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