Gene Page: PSEN2

Summary
GeneID  5664
Symbol  PSEN2
Synonyms  AD3L|AD4|PS2|STM2
Description  presenilin 2 (Alzheimer disease 4)
See related  HGNC:9509|MIM:600759|Ensembl:ENSG00000143801|HPRD:02860|
Locus tag  -
Gene type  protein-coding
Map location  1q31-q42
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0687 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
IFI350.950.94
MT1E0.910.90
RTP40.900.84
PSMB90.900.93
B2M0.890.90
IFITM10.890.88
TAP10.870.83
RARRES30.870.92
OAS10.870.83
OASL0.870.83
Top 10 negatively co-expressed genes
ANKRD17-0.68-0.79
MCM3AP-0.68-0.81
EIF4ENIF1-0.68-0.79
MYO18A-0.68-0.72
SFRS14-0.68-0.81
HEATR5B-0.68-0.82
USP7-0.68-0.77
CKAP5-0.68-0.82
PDXDC1-0.67-0.78
SPTAN1-0.67-0.80
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI12297508 
GO:0008233peptidase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0042987amyloid precursor protein catabolic processTAS15274632 
GO:0006509membrane protein ectodomain proteolysisIDA15274632 
GO:0007220Notch receptor processingTAS15274632 
GO:0008632apoptotic programTAS8939861 
GO:0007059chromosome segregationTAS9298903 
GO:0016485protein processingIDA15274632 
GO:0043085positive regulation of catalytic activityIDA15274632 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000139Golgi membraneIEA-
GO:0000776kinetochoreTAS9298903 
GO:0005794Golgi apparatusIDA15274632 
GO:0005789endoplasmic reticulum membraneIEA-
GO:0005639integral to nuclear inner membraneTAS9298903 
GO:0005783endoplasmic reticulumIDA15274632 
GO:0016020membraneIEA-
GO:0005887integral to plasma membraneIDA15274632 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
APBA1D9S411E | MINT1 | X11 | X11A | X11ALPHAamyloid beta (A4) precursor protein-binding, family A, member 1Affinity Capture-WesternBioGRID12196555 
APBA2D15S1518E | HsT16821 | LIN-10 | MGC99508 | MGC:14091 | MINT2 | X11Lamyloid beta (A4) precursor protein-binding, family A, member 2Affinity Capture-WesternBioGRID12196555 
APBA3MGC:15815 | X11L2 | mint3amyloid beta (A4) precursor protein-binding, family A, member 3Affinity Capture-WesternBioGRID12196555 
APH1A6530402N02Rik | APH-1A | CGI-78anterior pharynx defective 1 homolog A (C. elegans)-HPRD,BioGRID12297508 |12471034 
APH1BAPH-1B | DKFZp564D0372 | PRO1328 | PSFL | TAAV688anterior pharynx defective 1 homolog B (C. elegans)-HPRD12297508 
APPAAA | ABETA | ABPP | AD1 | APPI | CTFgamma | CVAP | PN2amyloid beta (A4) precursor proteinPS2 interacts with APP.BIND9223340 
BCL2L1BCL-XL/S | BCL2L | BCLX | Bcl-X | DKFZp781P2092 | bcl-xL | bcl-xSBCL2-like 1-HPRD,BioGRID10446169 
CAPN1CANP | CANP1 | CANPL1 | muCANP | muCLcalpain 1, (mu/I) large subunit-HPRD,BioGRID9852298 
CIB1CIB | KIP | KIP1 | SIP2-28calcium and integrin binding 1 (calmyrin)-HPRD,BioGRID10366599 
CTNND2GT24 | NPRAPcatenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)-HPRD10037471 
DOCK3KIAA0299 | MOCA | PBPdedicator of cytokinesis 3-HPRD10854253 
FHL2AAG11 | DRAL | SLIM3four and a half LIM domains 2-HPRD,BioGRID11001931 
FLNBABP-278 | AOI | DKFZp686A1668 | DKFZp686O033 | FH1 | FLN1L | LRS1 | SCT | TABP | TAPfilamin B, beta (actin binding protein 278)-HPRD,BioGRID9437013 
GFAPFLJ45472glial fibrillary acidic proteinTwo-hybridBioGRID12058025 
ICAM5TLCN | TLNintercellular adhesion molecule 5, telencephalin-HPRD,BioGRID11719200 
KCNIP3CSEN | DREAM | KCHIP3 | MGC18289Kv channel interacting protein 3, calsenilin-HPRD,BioGRID9771752 
KCNIP4CALP | KCHIP4 | MGC44947Kv channel interacting protein 4-HPRD,BioGRID11847232 
METTL2BFLJ11350 | FLJ12760 | METL | METTL2 | METTL2A | PSENIP1methyltransferase like 2B-HPRD,BioGRID11738826 
NCSTNAPH2 | KIAA0253nicastrin-HPRD,BioGRID10993067 
PSEN1AD3 | FAD | PS1 | S182presenilin 1Affinity Capture-WesternBioGRID12471034 
PSENENMDS033 | MSTP064 | PEN-2 | PEN2presenilin enhancer 2 homolog (C. elegans)-HPRD,BioGRID12198112 |12639958 
SRIFLJ26259 | SCNsorcin-HPRD,BioGRID10748169 
UBQLN1DA41 | DSK2 | FLJ90054 | PLIC-1 | XDRP1ubiquilin 1-HPRD,BioGRID11076969 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_NOTCH_SIGNALING_PATHWAY 4735All SZGR genes in this pathway
KEGG_ALZHEIMERS_DISEASE 169110All SZGR genes in this pathway
BIOCARTA_HIVNEF_PATHWAY 5843All SZGR genes in this pathway
PID_LKB1_PATHWAY 4737All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB4 9067All SZGR genes in this pathway
REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 3830All SZGR genes in this pathway
REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS 2718All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH4 1210All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH2 1210All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH1 7046All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH3 1210All SZGR genes in this pathway
REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR 109All SZGR genes in this pathway
REACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS 1510All SZGR genes in this pathway
REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE 6043All SZGR genes in this pathway
REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING 8161All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH 10364All SZGR genes in this pathway
DAVICIONI_PAX_FOXO1_SIGNATURE_IN_ARMS_UP 5938All SZGR genes in this pathway
DAVICIONI_MOLECULAR_ARMS_VS_ERMS_UP 332228All SZGR genes in this pathway
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_UP 255177All SZGR genes in this pathway
HOEBEKE_LYMPHOID_STEM_CELL_DN 8659All SZGR genes in this pathway
ELVIDGE_HYPOXIA_DN 14694All SZGR genes in this pathway
ELVIDGE_HIF1A_TARGETS_UP 6740All SZGR genes in this pathway
LIU_CDX2_TARGETS_UP 3622All SZGR genes in this pathway
HUMMERICH_SKIN_CANCER_PROGRESSION_DN 10064All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_DN 203134All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS 734436All SZGR genes in this pathway
BENPORATH_MYC_TARGETS_WITH_EBOX 230156All SZGR genes in this pathway
SHIN_B_CELL_LYMPHOMA_CLUSTER_2 3023All SZGR genes in this pathway
LEE_LIVER_CANCER_MYC_TGFA_DN 6544All SZGR genes in this pathway
UEDA_PERIFERAL_CLOCK 169111All SZGR genes in this pathway
HADDAD_T_LYMPHOCYTE_AND_NK_PROGENITOR_UP 7856All SZGR genes in this pathway
ABRAHAM_ALPC_VS_MULTIPLE_MYELOMA_DN 1914All SZGR genes in this pathway
TAKAO_RESPONSE_TO_UVB_RADIATION_DN 9867All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_DN 287208All SZGR genes in this pathway
RAMASWAMY_METASTASIS_UP 6643All SZGR genes in this pathway
BURTON_ADIPOGENESIS_6 189112All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_P3 160103All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP 863514All SZGR genes in this pathway
BOCHKIS_FOXA2_TARGETS 425261All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN 366257All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP 338225All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_UP 418282All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_DN 245150All SZGR genes in this pathway
HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_DN 7247All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-18374811A,m8hsa-miR-183UAUGGCACUGGUAGAAUUCACUG
miR-30-5p121127m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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