Gene Page: LRP8

Summary
GeneID  7804
Symbol  LRP8
Synonyms  APOER2|HSZ75190|MCI1
Description  low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
See related  HGNC:6700|MIM:602600|Ensembl:ENSG00000157193|HPRD:04002|
Locus tag  -
Gene type  protein-coding
Map location  1p34
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 3.9483 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004888transmembrane receptor activityTAS8626535 
GO:0030229very-low-density lipoprotein receptor activityIDA8626535 
GO:0030227apolipoprotein E receptor activityIDA8626535 
GO:0030227apolipoprotein E receptor activityTAS11152697 
GO:0005509calcium ion bindingIEA-
GO:0008034lipoprotein bindingIC11152697 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006508proteolysisNAS11152697 
GO:0007165signal transductionTAS10380922 
GO:0006629lipid metabolic processNAS11152697 
GO:0006897endocytosisIDA8626535 
GO:0019221cytokine-mediated signaling pathwayNAS11152697 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0016021integral to membraneIC11152697 
GO:0005901caveolaIDA11369809 
GO:0005886plasma membraneNAS10380922 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ANAPC10APC10 | DKFZp564L0562 | DOC1anaphase promoting complex subunit 10Two-hybridBioGRID10827173 
APBA2D15S1518E | HsT16821 | LIN-10 | MGC99508 | MGC:14091 | MINT2 | X11Lamyloid beta (A4) precursor protein-binding, family A, member 2Two-hybridBioGRID10827173 
APOEAD2 | LPG | MGC1571 | apoproteinapolipoprotein E-HPRD,BioGRID12167620 |12950167 
APOHB2G1 | BGapolipoprotein H (beta-2-glycoprotein I)-HPRD,BioGRID12807892 
CLUAAG4 | APOJ | CLI | KUB1 | MGC24903 | SGP-2 | SGP2 | SP-40 | TRPM-2 | TRPM2clusterin-HPRD12824284 
DAB1-disabled homolog 1 (Drosophila)-HPRD10380922 
Two-hybridBioGRID10827173 
DLG4FLJ97752 | FLJ98574 | PSD95 | SAP90discs, large homolog 4 (Drosophila)Two-hybridBioGRID10827173 
GIPC1C19orf3 | GIPC | GLUT1CBP | Hs.6454 | IIP-1 | MGC15889 | MGC3774 | NIP | RGS19IP1 | SEMCAP | SYNECTIIN | SYNECTIN | TIP-2GIPC PDZ domain containing family, member 1Two-hybridBioGRID10827173 
ITGB1BP1DKFZp686K08158 | ICAP-1A | ICAP-1B | ICAP-1alpha | ICAP1 | ICAP1A | ICAP1Bintegrin beta 1 binding protein 1Two-hybridBioGRID10827173 
LRPAP1A2MRAP | A2RAP | HBP44 | MGC138272 | MRAP | RAPlow density lipoprotein receptor-related protein associated protein 1-HPRD,BioGRID12899622 
MAPK8IP1IB1 | JIP-1 | JIP1 | PRKM8IPmitogen-activated protein kinase 8 interacting protein 1Two-hybridBioGRID10827173 
MAPK8IP2IB2 | JIP2 | PRKM8IPLmitogen-activated protein kinase 8 interacting protein 2Two-hybridBioGRID10827173 
NOS1AP6330408P19Rik | CAPON | MGC138500nitric oxide synthase 1 (neuronal) adaptor proteinTwo-hybridBioGRID10827173 
RELNPRO1598 | RLreelin-HPRD,BioGRID10571240 |12167620 
|12670700 |12899622 
SCN3AKIAA1356 | NAC3 | Nav1.3sodium channel, voltage-gated, type III, alpha subunitTwo-hybridBioGRID10827173 
SNX17KIAA0064sorting nexin 17-HPRD,BioGRID12169628 
SYNJ2BPARIP2 | FLJ11271 | FLJ41973 | OMP25synaptojanin 2 binding proteinTwo-hybridBioGRID10827173 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_REELIN_PATHWAY 2929All SZGR genes in this pathway
PID_LIS1_PATHWAY 2822All SZGR genes in this pathway
REACTOME_PLATELET_HOMEOSTASIS 7849All SZGR genes in this pathway
REACTOME_PLATELET_SENSITIZATION_BY_LDL 169All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_UP 285181All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
FOURNIER_ACINAR_DEVELOPMENT_EARLY_DN 65All SZGR genes in this pathway
ZHONG_RESPONSE_TO_AZACITIDINE_AND_TSA_DN 7038All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
HORIUCHI_WTAP_TARGETS_DN 310188All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_UP 430232All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_RED_UP 1713All SZGR genes in this pathway
UDAYAKUMAR_MED1_TARGETS_UP 13582All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
KIM_WT1_TARGETS_12HR_DN 209122All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
ROSTY_CERVICAL_CANCER_PROLIFERATION_CLUSTER 14073All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_UP 414287All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN 637377All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX 795478All SZGR genes in this pathway
BENPORATH_ES_1 379235All SZGR genes in this pathway
BENPORATH_PROLIFERATION 14780All SZGR genes in this pathway
AMIT_EGF_RESPONSE_240_HELA 6043All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
LEE_TARGETS_OF_PTCH1_AND_SUFU_DN 8369All SZGR genes in this pathway
SWEET_KRAS_TARGETS_DN 6639All SZGR genes in this pathway
ASTON_MAJOR_DEPRESSIVE_DISORDER_DN 160110All SZGR genes in this pathway
POMEROY_MEDULLOBLASTOMA_DESMOPLASIC_VS_CLASSIC_UP 6238All SZGR genes in this pathway
MANALO_HYPOXIA_DN 289166All SZGR genes in this pathway
SCHUHMACHER_MYC_TARGETS_UP 8057All SZGR genes in this pathway
URS_ADIPOCYTE_DIFFERENTIATION_UP 7451All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
HARRIS_HYPOXIA 8164All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_8HR_DN 4731All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_24HR_UP 14896All SZGR genes in this pathway
BILD_HRAS_ONCOGENIC_SIGNATURE 261166All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP 566371All SZGR genes in this pathway
DURCHDEWALD_SKIN_CARCINOGENESIS_DN 264168All SZGR genes in this pathway
SANSOM_APC_TARGETS_REQUIRE_MYC 210123All SZGR genes in this pathway
HELLER_HDAC_TARGETS_DN 292189All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_DN 281179All SZGR genes in this pathway
YOKOE_CANCER_TESTIS_ANTIGENS 3822All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_DN 353226All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_DN 270181All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP 430288All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_A_DN 187All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP 648398All SZGR genes in this pathway
IZADPANAH_STEM_CELL_ADIPOSE_VS_BONE_UP 12692All SZGR genes in this pathway
MATZUK_SPERMATOZOA 11477All SZGR genes in this pathway
GRADE_COLON_AND_RECTAL_CANCER_UP 285167All SZGR genes in this pathway
POOLA_INVASIVE_BREAST_CANCER_UP 288168All SZGR genes in this pathway
YAGI_AML_WITH_INV_16_TRANSLOCATION 422277All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_30MIN_DN 15099All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_4HR_DN 254158All SZGR genes in this pathway
KARLSSON_TGFB1_TARGETS_UP 12778All SZGR genes in this pathway
WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_DN 374217All SZGR genes in this pathway
LU_EZH2_TARGETS_DN 414237All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_6HR_UP 229149All SZGR genes in this pathway
PANGAS_TUMOR_SUPPRESSION_BY_SMAD1_AND_SMAD5_DN 157106All SZGR genes in this pathway
PASINI_SUZ12_TARGETS_DN 315215All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_10HR_UP 199143All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_UP 279155All SZGR genes in this pathway
GHANDHI_DIRECT_IRRADIATION_UP 11068All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-130/3012382451A,m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-148/152115411601Ahsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-330423429m8hsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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