Gene Page: ACTN2

Summary
GeneID  88
Symbol  ACTN2
Synonyms  CMD1AA
Description  actinin, alpha 2
See related  HGNC:164|MIM:102573|Ensembl:ENSG00000077522|HPRD:00019|
Locus tag  -
Gene type  protein-coding
Map location  1q42-q43
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 1.2291 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
RBM90.960.97
POLR3A0.960.98
CSRNP20.960.97
WDR820.960.98
NCAM10.950.96
PHF200.950.96
ZNF3170.940.96
SEC24C0.940.96
KIDINS2200.940.96
STAU10.940.96
Top 10 negatively co-expressed genes
AF347015.31-0.76-0.90
FXYD1-0.75-0.89
MT-CO2-0.75-0.91
SERPINB6-0.75-0.78
AF347015.33-0.74-0.87
S100B-0.73-0.85
AF347015.27-0.73-0.88
HSD17B14-0.73-0.81
TSC22D4-0.73-0.81
HEPN1-0.73-0.79
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003779actin bindingIEA-
GO:0005178integrin bindingTAS8104223 
GO:0005509calcium ion bindingIEA-
GO:0008307structural constituent of muscleTAS1339456 
GO:0042802identical protein bindingIPI9501083 
GO:0051374FATZ 1 bindingIDA11699871 
GO:0051370ZASP bindingIDA10427098 |11699871 
GO:0046983protein dimerization activityIDA9501083 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007155cell adhesionTAS10656685 
GO:0048041focal adhesion formationIMP16807302 
GO:0042981regulation of apoptosisNAS16807302 
GO:0030035microspike biogenesisIDA12356918 
GO:0051289protein homotetramerizationIDA9501083 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0030175filopodiumIDAaxon (GO term level: 5)12356918 
GO:0043197dendritic spineTASSynap, dendrite (GO term level: 7)15841212 
GO:0005856cytoskeletonNAS12809483 
GO:0005730nucleolusIDA18029348 
GO:0005737cytoplasmIEA-
GO:0005925focal adhesionIMP16807302 
GO:0005884actin filamentTAS1339456 
GO:0031143pseudopodiumTAS1629252 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ADAM12MCMP | MCMPMltna | MLTN | MLTNAADAM metallopeptidase domain 12-HPRD,BioGRID10788519 
ANGALS9 | HEL168 | MGC22466 | MGC71966 | RNASE4 | RNASE5angiogenin, ribonuclease, RNase A family, 5ANG interacts with ACTN2. This interaction was modeled on a demonstrated interaction between ANG from unspecified species and human ACTN2.BIND15737636 
CAPN1CANP | CANP1 | CANPL1 | muCANP | muCLcalpain 1, (mu/I) large subunitCAPN1 interacts with ACTN2.BIND12358155 
DISC1C1orf136 | FLJ13381 | FLJ21640 | FLJ25311 | FLJ41105 | KIAA0457 | SCZD9disrupted in schizophrenia 1DISC-1 interacts with alpha-actinin 2.BIND12812986 
-HPRD,BioGRID12812986 
DLG1DKFZp761P0818 | DKFZp781B0426 | DLGH1 | SAP97 | dJ1061C18.1.1 | hdlgdiscs, large homolog 1 (Drosophila)-HPRD,BioGRID12860415 
DLG4FLJ97752 | FLJ98574 | PSD95 | SAP90discs, large homolog 4 (Drosophila)-HPRD,BioGRID12435606 
EPS8L1DRC3 | EPS8R1 | FLJ20258 | MGC23164 | MGC4642 | PP10566EPS8-like 1-HPRD14565974 
GRIN1NMDA1 | NMDAR1 | NR1glutamate receptor, ionotropic, N-methyl D-aspartate 1-HPRD9009191 |9728925 
|9952395 
alpha-actinin-2 interacts with NR1A. This interaction was modeled on a demonstrated interaction between human alpha-actinin-2 and NR1A from an unspecified species.BIND9009191 
GRIN2BMGC142178 | MGC142180 | NMDAR2B | NR2B | hNR3glutamate receptor, ionotropic, N-methyl D-aspartate 2B-HPRD,BioGRID9009191 
KCNA5ATFB7 | HCK1 | HK2 | HPCN1 | KV1.5 | MGC117058 | MGC117059 | PCN1potassium voltage-gated channel, shaker-related subfamily, member 5-HPRD,BioGRID10812072 
LDB3CYPHER | FLJ35865 | KIAA01613 | KIAA0613 | ORACLE | PDLIM6 | ZASP | ldb3z1 | ldb3z4LIM domain binding 3-HPRD,BioGRID10391924 
ZASP interacts with Alpha-actinin 2.BIND11842093 
LRP12DKFZp781F1053 | FLJ12929 | ST7low density lipoprotein-related protein 12-HPRD12809483 
MYOZ1CS-2 | FATZ | MYOZmyozenin 1FATZ interacts with ACTN2.BIND10984498 
-HPRD,BioGRID10984498 
MYOZ2C4orf5 | CS-1myozenin 2-HPRD11842093 
MYOZ3CS-3 | CS3 | FRP3myozenin 3-HPRD11842093 
MYPNMYOPmyopalladin-HPRD,BioGRID11309420 
PALLDCGI-151 | FLJ22190 | FLJ38193 | FLJ39139 | KIAA0992 | PNCA1 | SIH002palladin, cytoskeletal associated protein-HPRD10931874 
PDLIM1CLIM1 | CLP-36 | CLP36 | hCLIM1PDZ and LIM domain 1-HPRD,BioGRID10861853 
RAVER1KIAA1978ribonucleoprotein, PTB-binding 1-HPRD11724819 
SELECD62E | ELAM | ELAM1 | ESEL | LECAM2selectin E-HPRD8609175 
SSX2IPADIP | FLJ10848 | KIAA0923 | MGC75026synovial sarcoma, X breakpoint 2 interacting protein-HPRD12446711 
ST7DKFZp762O2113 | ETS7q | FAM4A | FAM4A1 | HELG | RAY1 | SEN4 | TSG7suppression of tumorigenicity 7Two-hybridBioGRID12809483 
TNNTN-Wtenascin NReconstituted ComplexBioGRID9817758 
 


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