Gene Page: EPHB2

Summary
GeneID  2048
Symbol  EPHB2
Synonyms  CAPB|DRT|EPHT3|ERK|Hek5|MGC87492|PCBC|Tyro5
Description  EPH receptor B2
See related  HGNC:3393|MIM:600997|Ensembl:ENSG00000133216|HPRD:02997|
Locus tag  -
Gene type  protein-coding
Map location  1p36.1-p35
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 7 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.1976 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ZNF4440.830.87
PRAF20.820.83
EPN10.810.84
FBXW50.810.84
RNF1260.810.83
ZNF5800.800.84
PIM30.800.85
AC129492.20.800.82
C11orf680.790.82
DAPK30.790.82
Top 10 negatively co-expressed genes
AF347015.21-0.53-0.43
AF347015.8-0.49-0.41
AF347015.31-0.49-0.41
MT-CO2-0.48-0.39
MT-ATP8-0.47-0.45
AF347015.27-0.46-0.40
MT-CYB-0.46-0.38
AF347015.33-0.45-0.38
NOSTRIN-0.45-0.40
AF347015.18-0.44-0.38
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0008046axon guidance receptor activityIEAaxon (GO term level: 6)-
GO:0005102receptor bindingIEANeurotransmitter (GO term level: 4)-
GO:0000166nucleotide bindingIEA-
GO:0005005transmembrane-ephrin receptor activityTAS8589679 
GO:0004872receptor activityIEA-
GO:0005524ATP bindingIEA-
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007411axon guidanceIEAaxon (GO term level: 13)-
GO:0048170positive regulation of long-term neuronal synaptic plasticityIEAneuron, neurogenesis, Synap (GO term level: 11)-
GO:0048168regulation of neuronal synaptic plasticityIEAneuron, Synap (GO term level: 9)-
GO:0050770regulation of axonogenesisIEAneuron, axon (GO term level: 13)-
GO:0007399nervous system developmentTASneurite (GO term level: 5)8589679 
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayIEA-
GO:0006468protein amino acid phosphorylationTAS-
GO:0009887organ morphogenesisIEA-
GO:0007612learningIEA-
GO:0045786negative regulation of cell cycleIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0016021integral to membraneTAS-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinase-HPRD,BioGRID11494128 
ACP1HAAP | MGC111030 | MGC3499acid phosphatase 1, soluble-HPRD,BioGRID9499402 
ADAM17CD156b | MGC71942 | TACE | cSVPADAM metallopeptidase domain 17-HPRD12058067 
BCL2Bcl-2B-cell CLL/lymphoma 2Biochemical ActivityBioGRID15225643 
CRKCRKIIv-crk sarcoma virus CT10 oncogene homolog (avian)Reconstituted ComplexBioGRID10644995 
EFNB1CFND | CFNS | EFL3 | EPLG2 | Elk-L | LERK2 | MGC8782ephrin-B1-HPRD8878483 
The membrane bound ligand ELK-L interacts with the receptor NUK. This interaction was modeled on a demonstrated interaction between ELK-L from human and NUK from mouse.BIND8755474 
EFNB2EPLG5 | HTKL | Htk-L | LERK5 | MGC126226 | MGC126227 | MGC126228ephrin-B2The membrane bound ligand HTK-L interacts with the receptor NUK. This interaction was modeled on a demonstrated interaction between HTK-L from human and NUK from mouse.BIND8755474 
-HPRD,BioGRID11780069 
EPHB2CAPB | DRT | EPHT3 | ERK | Hek5 | MGC87492 | PCBC | Tyro5EPH receptor B2-HPRD,BioGRID9933164 
GRIN1NMDA1 | NMDAR1 | NR1glutamate receptor, ionotropic, N-methyl D-aspartate 1-HPRD11754835 
ITSN1ITSN | MGC134948 | MGC134949 | SH3D1A | SH3P17intersectin 1 (SH3 domain protein)-HPRD,BioGRID12389031 
MLLT4AF-6 | AF6 | AFADIN | FLJ34371 | RP3-431P23.3myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4EphB2 interacts with AF6. This interaction was modelled on a demonstrated interaction between EphB2 from human and mouse AF6.BIND9707552 
-HPRD,BioGRID9707552 
NCK1MGC12668 | NCK | NCKalphaNCK adaptor protein 1-HPRD9233798 
RASA1CM-AVM | CMAVM | DKFZp434N071 | GAP | PKWS | RASA | RASGAP | p120GAP | p120RASGAPRAS p21 protein activator (GTPase activating protein) 1-HPRD,BioGRID9233798 |10644995 
RP6-213H19.1MASK | MST4serine/threonine protein kinase MST4Phenotypic EnhancementBioGRID11641781 
RYKD3S3195 | JTK5 | JTK5A | RYK1RYK receptor-like tyrosine kinase-HPRD,BioGRID11956217 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)-HPRD,BioGRID9632142 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_AXON_GUIDANCE 129103All SZGR genes in this pathway
ST_GA12_PATHWAY 2316All SZGR genes in this pathway
ST_G_ALPHA_I_PATHWAY 3529All SZGR genes in this pathway
ST_GRANULE_CELL_SURVIVAL_PATHWAY 2723All SZGR genes in this pathway
ST_INTEGRIN_SIGNALING_PATHWAY 8262All SZGR genes in this pathway
ST_T_CELL_SIGNAL_TRANSDUCTION 4533All SZGR genes in this pathway
ST_B_CELL_ANTIGEN_RECEPTOR 4032All SZGR genes in this pathway
ST_FAS_SIGNALING_PATHWAY 6554All SZGR genes in this pathway
ST_MYOCYTE_AD_PATHWAY 2725All SZGR genes in this pathway
PID_EPHB_FWD_PATHWAY 4038All SZGR genes in this pathway
PID_SYNDECAN_2_PATHWAY 3327All SZGR genes in this pathway
PID_EPHRINB_REV_PATHWAY 3025All SZGR genes in this pathway
LAIHO_COLORECTAL_CANCER_SERRATED_DN 8647All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_UP 430232All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_DN 12686All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_DN 162116All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_DN 260143All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
PROVENZANI_METASTASIS_UP 194112All SZGR genes in this pathway
BEGUM_TARGETS_OF_PAX3_FOXO1_FUSION_DN 4534All SZGR genes in this pathway
XU_HGF_TARGETS_INDUCED_BY_AKT1_48HR_UP 148All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN 428306All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_UP 256159All SZGR genes in this pathway
ONDER_CDH1_SIGNALING_VIA_CTNNB1 8358All SZGR genes in this pathway
SWEET_KRAS_TARGETS_UP 8451All SZGR genes in this pathway
SANSOM_APC_TARGETS_UP 12684All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
HENDRICKS_SMARCA4_TARGETS_UP 5635All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_UP 249170All SZGR genes in this pathway
VERRECCHIA_DELAYED_RESPONSE_TO_TGFB1 3926All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_DN 287208All SZGR genes in this pathway
VERRECCHIA_RESPONSE_TO_TGFB1_C4 1310All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_24HR_UP 14896All SZGR genes in this pathway
SANSOM_APC_TARGETS 212121All SZGR genes in this pathway
SANSOM_APC_TARGETS_REQUIRE_MYC 210123All SZGR genes in this pathway
SANSOM_WNT_PATHWAY_REQUIRE_MYC 5843All SZGR genes in this pathway
ZHENG_GLIOBLASTOMA_PLASTICITY_UP 250168All SZGR genes in this pathway
GRADE_COLON_AND_RECTAL_CANCER_UP 285167All SZGR genes in this pathway
HUANG_DASATINIB_RESISTANCE_UP 8153All SZGR genes in this pathway
FIRESTEIN_PROLIFERATION 175125All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN 13892All SZGR genes in this pathway
MCMURRAY_TP53_HRAS_COOPERATION_RESPONSE_DN 6746All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_DN 668419All SZGR genes in this pathway
JISON_SICKLE_CELL_DISEASE_UP 181106All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_UP 176110All SZGR genes in this pathway
CHICAS_RB1_TARGETS_CONFLUENT 567365All SZGR genes in this pathway
MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_UP 259159All SZGR genes in this pathway
LEE_BMP2_TARGETS_DN 882538All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_DN 553343All SZGR genes in this pathway
PLASARI_NFIC_TARGETS_BASAL_DN 1813All SZGR genes in this pathway
PLASARI_TGFB1_SIGNALING_VIA_NFIC_1HR_UP 3325All SZGR genes in this pathway
DELACROIX_RARG_BOUND_MEF 367231All SZGR genes in this pathway
ZWANG_EGF_PERSISTENTLY_DN 6136All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-128149715041A,m8hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-1503093161A,m8hsa-miR-150UCUCCCAACCCUUGUACCAGUG
miR-1853533601A,m8hsa-miR-185brainUGGAGAGAAAGGCAGUUC
miR-203.110121018m8hsa-miR-203UGAAAUGUUUAGGACCACUAG
hsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-224107110771Ahsa-miR-224CAAGUCACUAGUGGUUCCGUUUA
miR-24*107610821Ahsa-miR-189GUGCCUACUGAGCUGAUAUCAGU
miR-2714981504m8hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-30-5p8888951A,m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-44811031109m8hsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
miR-495885891m8hsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
hsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
hsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
miR-911771183m8hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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