Gene Page: MACF1

Summary
GeneID  23499
Symbol  MACF1
Synonyms  ABP620|ACF7|FLJ45612|FLJ46776|KIAA0465|KIAA1251|MACF|OFC4
Description  microtubule-actin crosslinking factor 1
See related  HGNC:13664|MIM:608271|Ensembl:ENSG00000127603|HPRD:09750|
Locus tag  -
Gene type  protein-coding
Map location  1p32-p31
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenics, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.7115 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003779actin bindingIEA-
GO:0005509calcium ion bindingIEA-
GO:0005509calcium ion bindingNAS-
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI17043677 
GO:0004553hydrolase activity, hydrolyzing O-glycosyl compoundsIEA-
GO:0008017microtubule bindingIEA-
GO:0008017microtubule bindingNAS-
GO:0051015actin filament bindingNAS10529403 |10559237 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001707mesoderm formationIEA-
GO:0016055Wnt receptor signaling pathwayIEA-
GO:0005975carbohydrate metabolic processIEA-
GO:0007163establishment or maintenance of cell polarityIEA-
GO:0007050cell cycle arrestIEA-
GO:0008150biological_processND-
GO:0006928cell motionIEA-
GO:0006620posttranslational protein targeting to membraneIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005856cytoskeletonIEA-
GO:0005856cytoskeletonNAS10529403 
GO:0005737cytoplasmIDA10559237 
GO:0005737cytoplasmISS-
GO:0015630microtubule cytoskeletonIEA-
GO:0015629actin cytoskeletonIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CNTNAP2AUTS15 | CASPR2 | CDFE | DKFZp781D1846 | NRXN4contactin associated protein-like 2-HPRD12421765 
CNTNAP4CASPR4 | KIAA1763contactin associated protein-like 4-HPRD12421765 
GOLGA4GCP2 | GOLG | MU-RMS-40.18 | p230golgi autoantigen, golgin subfamily a, 4p230 interacts with MACF1.BIND15265687 
-HPRD15265687 
NRCAMKIAA0343 | MGC138845 | MGC138846neuronal cell adhesion molecule-HPRD12421765 
NRXN1DKFZp313P2036 | FLJ35941 | Hs.22998 | KIAA0578neurexin 1-HPRD12421765 
NRXN2FLJ40892 | KIAA0921neurexin 2-HPRD12421765 
PLXND1KIAA0620 | MGC75353 | PLEXD1plexin D1-HPRD12421765 
TMCO7FLJ12688 | KIAA1746transmembrane and coiled-coil domains 7-HPRD12421765 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN 634384All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
LAIHO_COLORECTAL_CANCER_SERRATED_UP 11271All SZGR genes in this pathway
HOEBEKE_LYMPHOID_STEM_CELL_UP 9564All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_DN 281186All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_GRANULOCYTE_UP 5534All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN 485334All SZGR genes in this pathway
LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN 800473All SZGR genes in this pathway
EBAUER_TARGETS_OF_PAX3_FOXO1_FUSION_UP 207128All SZGR genes in this pathway
EBAUER_MYOGENIC_TARGETS_OF_PAX3_FOXO1_FUSION 5026All SZGR genes in this pathway
XU_HGF_SIGNALING_NOT_VIA_AKT1_48HR_UP 3520All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
WOOD_EBV_EBNA1_TARGETS_DN 4733All SZGR genes in this pathway
DAIRKEE_TERT_TARGETS_DN 12479All SZGR genes in this pathway
KIM_MYCN_AMPLIFICATION_TARGETS_UP 9264All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP 479299All SZGR genes in this pathway
ROPERO_HDAC2_TARGETS 11471All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN 514330All SZGR genes in this pathway
GEORGES_CELL_CYCLE_MIR192_TARGETS 6246All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP 424268All SZGR genes in this pathway
SAKAI_TUMOR_INFILTRATING_MONOCYTES_DN 8151All SZGR genes in this pathway
MORI_LARGE_PRE_BII_LYMPHOCYTE_DN 5839All SZGR genes in this pathway
MORI_MATURE_B_LYMPHOCYTE_UP 9062All SZGR genes in this pathway
YU_MYC_TARGETS_DN 5538All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_16HR_DN 8662All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_DN 10170All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP 566371All SZGR genes in this pathway
DURCHDEWALD_SKIN_CARCINOGENESIS_DN 264168All SZGR genes in this pathway
ZHENG_BOUND_BY_FOXP3 491310All SZGR genes in this pathway
DE_YY1_TARGETS_DN 9264All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_DN 249165All SZGR genes in this pathway
BONCI_TARGETS_OF_MIR15A_AND_MIR16_1 9175All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
ZHANG_TLX_TARGETS_36HR_DN 185116All SZGR genes in this pathway
YAGI_AML_WITH_T_8_21_TRANSLOCATION 368247All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_6HR_UP 229149All SZGR genes in this pathway
LINSLEY_MIR16_TARGETS 206127All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.1126132m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/5061261321Ahsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-1389439501A,m8hsa-miR-138brainAGCUGGUGUUGUGAAUC
miR-142-5p3663721Ahsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
miR-15/16/195/424/4976406461Ahsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-1863643701Ahsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-195575641A,m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-192/2152542601Ahsa-miR-192CUGACCUAUGAAUUGACAGCC
hsa-miR-215AUGACCUAUGAAUUGACAGAC
miR-217118011861Ahsa-miR-217UACUGCAUCAGGAACUGAUUGGAU
miR-231631691Ahsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-25/32/92/363/3675875931Ahsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-37710841090m8hsa-miR-377AUCACACAAAGGCAACUUUUGU
miR-379112911351Ahsa-miR-379brainUGGUAGACUAUGGAACGUA
miR-409-5p197203m8hsa-miR-409-5pAGGUUACCCGAGCAACUUUGCA
miR-4108389m8hsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-421111111171Ahsa-miR-421GGCCUCAUUAAAUGUUUGUUG
miR-5036406461Ahsa-miR-503UAGCAGCGGGAACAGUUCUGCAG
miR-544111511211Ahsa-miR-544AUUCUGCAUUUUUAGCAAGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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