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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: SETDB1

Summary

GeneID

9869

Symbol

SETDB1

Synonyms

ESET|KG1T|KIAA0067|KMT1E

Description

SET domain, bifurcated 1

Locus tag

RP11-316M1.1

Gene type

protein-coding

Map location

1q21

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.0235

GSMA_IIA

genome scan meta-analysis (All samples)

Psr: 0.00814

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.125

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

WDR6

0.96

DCAF15

0.96

0.94

MTA1

0.95

VPS16A

0.94

0.93

AXIN1

0.94

RBM15B

0.94

0.93

PABPC4

0.94

0.91

EHMT2

0.94

CNTROB

0.93

0.96

CHFR

0.93

0.95

Top 10 negatively co-expressed genes

AF347015.31

-0.78

-0.87

AF347015.27

-0.78

-0.88

MT-CO2

-0.76

-0.87

C5orf53

-0.75

-0.77

AF347015.33

-0.75

-0.85

MT-CYB

-0.74

-0.84

AF347015.8

-0.73

-0.85

S100B

-0.72

-0.79

HLA-F

-0.72

-0.73

COPZ2

-0.71

-0.77

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0003677

DNA binding

IEA

GO:0005515

protein binding

IPI

11791185 |16682412 |17577629

GO:0016740

transferase activity

IEA

GO:0008270

zinc ion binding

IEA

GO:0008168

methyltransferase activity

IEA

GO:0018024

histone-lysine N-methyltransferase activity

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006355

regulation of transcription, DNA-dependent

IEA

GO:0006350

transcription

IEA

GO:0016568

chromatin modification

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005634

nucleus

IEA

GO:0005694

chromosome

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AIFM1	AIF \| MGC111425 \| PDCD8	apoptosis-inducing factor, mitochondrion-associated, 1	Two-hybrid	BioGRID	16169070
AOF2	BHC110 \| KDM1 \| KIAA0601 \| LSD1	amine oxidase (flavin containing) domain 2	Two-hybrid	BioGRID	16169070
ASAH1	AC \| ASAH \| FLJ21558 \| FLJ22079 \| PHP \| PHP32	N-acylsphingosine amidohydrolase (acid ceramidase) 1	Two-hybrid	BioGRID	16169070
ATF7IP	FLJ10139 \| FLJ10688 \| MCAF \| p621	activating transcription factor 7 interacting protein	-	HPRD	14536086
ATF7IP	FLJ10139 \| FLJ10688 \| MCAF \| p621	activating transcription factor 7 interacting protein	MCAF1 interacts with SETDB1.	BIND	15691849
ATF7IP2	FLJ12668 \| MCAF2	activating transcription factor 7 interacting protein 2	MCAF2 interacts with SETDB1.	BIND	15691849
BAT3	BAG-6 \| BAG6 \| D6S52E \| G3	HLA-B associated transcript 3	Two-hybrid	BioGRID	16169070
BHLHB2	DEC1 \| SHARP-2 \| STRA13 \| Stra14 \| bHLHe40	basic helix-loop-helix domain containing, class B, 2	Two-hybrid	BioGRID	16169070
BTBD2	-	BTB (POZ) domain containing 2	Two-hybrid	BioGRID	16169070
BXDC2	BRIX \| FLJ11100	brix domain containing 2	Two-hybrid	BioGRID	16169070
C11orf1	FLJ23499	chromosome 11 open reading frame 1	Two-hybrid	BioGRID	16169070
CBX8	HPC3 \| PC3 \| RC1	chromobox homolog 8 (Pc class homolog, Drosophila)	Two-hybrid	BioGRID	16169070
CCDC106	HSU79303 \| ZNF581	coiled-coil domain containing 106	Two-hybrid	BioGRID	16169070
CDK4	CMM3 \| MGC14458 \| PSK-J3	cyclin-dependent kinase 4	Two-hybrid	BioGRID	16169070
CHAF1A	CAF-1 \| CAF1 \| CAF1B \| CAF1P150 \| MGC71229 \| P150	chromatin assembly factor 1, subunit A (p150)	SETDB1 interacts with CAF-1.	BIND	15327775
CLSTN1	ALC-ALPHA \| CSTN1 \| FLJ32258 \| KIAA0911 \| PIK3CD \| XB31alpha \| alcalpha1 \| alcalpha2	calsyntenin 1	-	HPRD	12421765
CRELD1	AVSD2 \| CIRRIN \| DKFZp566D213	cysteine-rich with EGF-like domains 1	Two-hybrid	BioGRID	16169070
DAP	MGC99796	death-associated protein	Two-hybrid	BioGRID	16169070
DLEU1	BCMS \| DLB1 \| DLEU2 \| LEU1 \| LEU2 \| MGC22430 \| NCRNA00021 \| XTP6	deleted in lymphocytic leukemia 1 (non-protein coding)	Two-hybrid	BioGRID	16169070
ECSIT	SITPEC	ECSIT homolog (Drosophila)	Two-hybrid	BioGRID	16169070
ERH	DROER \| FLJ27340	enhancer of rudimentary homolog (Drosophila)	Two-hybrid	BioGRID	16169070
FLYWCH1	-	FLYWCH-type zinc finger 1	Two-hybrid	BioGRID	16169070
GIPC2	FLJ20075 \| SEMCAP-2 \| SEMCAP2	GIPC PDZ domain containing family, member 2	Two-hybrid	BioGRID	16169070
GPS2	AMF-1 \| MGC104294 \| MGC119287 \| MGC119288 \| MGC119289	G protein pathway suppressor 2	Two-hybrid	BioGRID	16169070
GSTO1	DKFZp686H13163 \| GSTTLp28 \| P28	glutathione S-transferase omega 1	Two-hybrid	BioGRID	16169070
HDAC1	DKFZp686H12203 \| GON-10 \| HD1 \| RPD3 \| RPD3L1	histone deacetylase 1	-	HPRD	12398767
HDAC2	RPD3 \| YAF1	histone deacetylase 2	Affinity Capture-Western	BioGRID	12398767
HIST2H3A	H3/n \| H3/o	histone cluster 2, H3a	Reconstituted Complex	BioGRID	11959841
HIST4H4	H4/p \| MGC24116	histone cluster 4, H4	Reconstituted Complex	BioGRID	11959841
HMOX2	HO-2	heme oxygenase (decycling) 2	Two-hybrid	BioGRID	16169070
HSPB3	HSPL27	heat shock 27kDa protein 3	Two-hybrid	BioGRID	16169070
MAD2L1BP	CMT2 \| KIAA0110 \| MGC11282 \| RP1-261G23.6	MAD2L1 binding protein	Two-hybrid	BioGRID	16169070
MBD1	CXXC3 \| PCM1 \| RFT	methyl-CpG binding domain protein 1	MBD1 interacts with SETDB1.	BIND	15327775
MOBKL3	2C4D \| CGI-95 \| MGC12264 \| MOB1 \| MOB3 \| PREI3	MOB1, Mps One Binder kinase activator-like 3 (yeast)	Two-hybrid	BioGRID	16169070
MRPL44	FLJ12701 \| FLJ13990 \| FLJ37688 \| L44MT \| MRP-L44	mitochondrial ribosomal protein L44	Two-hybrid	BioGRID	16169070
NIPSNAP3A	DKFZp564D177 \| FLJ13953 \| HSPC299 \| MGC14553 \| NIPSNAP4 \| TASSC	nipsnap homolog 3A (C. elegans)	Two-hybrid	BioGRID	16169070
OLFML3	HNOEL-iso \| OLF44	olfactomedin-like 3	Two-hybrid	BioGRID	16169070
ORAI2	C7orf19 \| CBCIP2 \| FLJ12474 \| FLJ14733 \| FLJ44818 \| TMEM142B	ORAI calcium release-activated calcium modulator 2	Two-hybrid	BioGRID	16169070
PAFAH1B3	-	platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa	Two-hybrid	BioGRID	16169070
PCDHA4	CNR1 \| CNRN1 \| CRNR1 \| MGC138307 \| MGC142169 \| PCDH-ALPHA4	protocadherin alpha 4	Two-hybrid	BioGRID	16169070
PGAM5	BXLBv68 \| MGC5352	phosphoglycerate mutase family member 5	Two-hybrid	BioGRID	16169070
PHF10	FLJ10975 \| MGC111009 \| XAP135	PHD finger protein 10	Two-hybrid	BioGRID	16169070
PLEKHA4	PEPP1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4	Two-hybrid	BioGRID	16169070
POLA2	FLJ21662 \| FLJ37250	polymerase (DNA directed), alpha 2 (70kD subunit)	Two-hybrid	BioGRID	16169070
PPA1	IOPPP \| MGC111556 \| PP \| PP1 \| SID6-8061	pyrophosphatase (inorganic) 1	Two-hybrid	BioGRID	16169070
PPP1R8	ARD-1 \| ARD1 \| NIPP-1 \| NIPP1 \| PRO2047	protein phosphatase 1, regulatory (inhibitor) subunit 8	Two-hybrid	BioGRID	16169070
PRKRA	DYT16 \| HSD14 \| PACT \| RAX	protein kinase, interferon-inducible double stranded RNA dependent activator	Two-hybrid	BioGRID	16169070
PSMD11	MGC3844 \| Rpn6 \| S9 \| p44.5	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	Two-hybrid	BioGRID	16169070
PTPRS	PTPSIGMA	protein tyrosine phosphatase, receptor type, S	Two-hybrid	BioGRID	16169070
QTRT1	FP3235 \| TGT	queuine tRNA-ribosyltransferase 1	Two-hybrid	BioGRID	16169070
RNF10	KIAA0262 \| MGC126758 \| MGC126764 \| RIE2	ring finger protein 10	Two-hybrid	BioGRID	16169070
S100A10	42C \| ANX2L \| ANX2LG \| CAL1L \| CLP11 \| Ca[1] \| GP11 \| MGC111133 \| P11 \| p10	S100 calcium binding protein A10	Two-hybrid	BioGRID	16169070
SAT1	DC21 \| KFSD \| SAT \| SSAT \| SSAT-1	spermidine/spermine N1-acetyltransferase 1	Two-hybrid	BioGRID	16169070
SERPINB9	CAP-3 \| CAP3 \| PI9	serpin peptidase inhibitor, clade B (ovalbumin), member 9	Two-hybrid	BioGRID	16169070
SIN3A	DKFZp434K2235 \| FLJ90319 \| KIAA0700	SIN3 homolog A, transcription regulator (yeast)	-	HPRD,BioGRID	12398767
SIN3B	KIAA0700	SIN3 homolog B, transcription regulator (yeast)	-	HPRD,BioGRID	12398767
SLC38A3	G17 \| NAT1 \| SN1	solute carrier family 38, member 3	Two-hybrid	BioGRID	16169070
SULT1E1	EST \| EST-1 \| MGC34459 \| STE	sulfotransferase family 1E, estrogen-preferring, member 1	Two-hybrid	BioGRID	16169070
SUZ12	CHET9 \| JJAZ1 \| KIAA0160	suppressor of zeste 12 homolog (Drosophila)	Co-purification	BioGRID	14536086
TARDBP	ALS10 \| TDP-43	TAR DNA binding protein	Two-hybrid	BioGRID	16169070
TCERG1	CA150 \| MGC133200 \| TAF2S	transcription elongation regulator 1	-	HPRD	15383276
THAP8	FLJ32891	THAP domain containing 8	Two-hybrid	BioGRID	16169070
TK1	TK2	thymidine kinase 1, soluble	Two-hybrid	BioGRID	16169070
TOB1	APRO6 \| MGC104792 \| MGC34446 \| PIG49 \| TOB \| TROB \| TROB1	transducer of ERBB2, 1	Two-hybrid	BioGRID	16169070
TOLLIP	FLJ33531 \| IL-1RAcPIP	toll interacting protein	Two-hybrid	BioGRID	16169070
TPI1	MGC88108 \| TPI	triosephosphate isomerase 1	Two-hybrid	BioGRID	16169070
TRBV2	TCRBV22S1A2N1T \| TCRBV2S1	T cell receptor beta variable 2	Two-hybrid	BioGRID	16169070
TRDMT1	DNMT2 \| M.HsaIIP \| PuMet \| RNMT1	tRNA aspartic acid methyltransferase 1	Two-hybrid	BioGRID	16169070
TRIB3	C20orf97 \| NIPK \| SINK \| SKIP3 \| TRB3	tribbles homolog 3 (Drosophila)	Two-hybrid	BioGRID	16169070
TRIM28	FLJ29029 \| KAP1 \| RNF96 \| TF1B \| TIF1B	tripartite motif-containing 28	-	HPRD,BioGRID	11959841
TSC22D1	DKFZp686O19206 \| MGC17597 \| RP11-269C23.2 \| TGFB1I4 \| TSC22	TSC22 domain family, member 1	Two-hybrid	BioGRID	16169070
TTR	HsT2651 \| PALB \| TBPA	transthyretin	Two-hybrid	BioGRID	16169070
TXNDC9	APACD	thioredoxin domain containing 9	Two-hybrid	BioGRID	16169070
ULK2	KIAA0623 \| Unc51.2	unc-51-like kinase 2 (C. elegans)	Two-hybrid	BioGRID	16169070
USP11	UHX1	ubiquitin specific peptidase 11	Two-hybrid	BioGRID	16169070
ZFP64	MGC940 \| ZNF338	zinc finger protein 64 homolog (mouse)	Two-hybrid	BioGRID	16169070
ZNF24	KOX17 \| RSG-A \| ZNF191 \| ZSCAN3 \| Zfp191	zinc finger protein 24	Two-hybrid	BioGRID	16169070

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_LYSINE_DEGRADATION	44	29	All SZGR genes in this pathway
PID_WNT_NONCANONICAL_PATHWAY	32	26	All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP	783	507	All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN	335	193	All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	855	609	All SZGR genes in this pathway
LOCKWOOD_AMPLIFIED_IN_LUNG_CANCER	214	139	All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS	882	572	All SZGR genes in this pathway
KAMMINGA_EZH2_TARGETS	41	26	All SZGR genes in this pathway
NOUZOVA_TRETINOIN_AND_H4_ACETYLATION	143	85	All SZGR genes in this pathway
TAKAO_RESPONSE_TO_UVB_RADIATION_DN	98	67	All SZGR genes in this pathway
BACOLOD_RESISTANCE_TO_ALKYLATING_AGENTS_DN	60	45	All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED	1022	619	All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED	1229	713	All SZGR genes in this pathway
LIN_MELANOMA_COPY_NUMBER_UP	73	53	All SZGR genes in this pathway
CHEN_HOXA5_TARGETS_9HR_UP	223	132	All SZGR genes in this pathway
ZHANG_TLX_TARGETS_36HR_UP	221	150	All SZGR genes in this pathway
ZHANG_TLX_TARGETS_60HR_DN	277	166	All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G1_UP	113	70	All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_4HR_DN	254	158	All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP	504	321	All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE	1137	655	All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_UP	344	215	All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_36HR	152	88	All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D	658	397	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-28	107	114	1A,m8	hsa-miR-28^brain	AAGGAGCUCACAGUCUAUUGAG
miR-29	159	166	1A,m8	hsa-miR-29a^SZ	UAGCACCAUCUGAAAUCGGUU
				hsa-miR-29b^SZ	UAGCACCAUUUGAAAUCAGUGUU
				hsa-miR-29c^SZ	UAGCACCAUUUGAAAUCGGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.