Gene Page: ACTA1

Summary
GeneID  58
Symbol  ACTA1
Synonyms  ACTA|ASMA|CFTD|CFTD1|CFTDM|MPFD|NEM1|NEM2|NEM3
Description  actin, alpha 1, skeletal muscle
See related  HGNC:129|MIM:102610|Ensembl:ENSG00000143632|HPRD:00030|
Locus tag  RP5-1068B5.2
Gene type  protein-coding
Map location  1q42.13|1q42.13-q42.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.1982 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI12849983 
GO:0005524ATP bindingIEA-
GO:0005524ATP bindingTAS10508519 
GO:0005198structural molecule activityIEA-
GO:0005200structural constituent of cytoskeletonTAS10508519 
GO:0017022myosin bindingTAS10508519 
GO:0043531ADP bindingTAS10508519 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0030240muscle thin filament assemblyIMP11333380 
GO:0006936muscle contractionTAS10508519 
GO:0048741skeletal muscle fiber developmentISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0001725stress fiberIDA15198992 
GO:0005856cytoskeletonIEA-
GO:0005865striated muscle thin filamentIDA15198992 
GO:0005737cytoplasmIEA-
GO:0005884actin filamentIDA12849983 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTR10ACTR11 | HARP11actin-related protein 10 homolog (S. cerevisiae)-HPRD12857853 
APC2APCLadenomatosis polyposis coli 2Co-localizationBioGRID11691822 
CCT4CCT-DELTA | Cctd | MGC126164 | MGC126165 | SRBchaperonin containing TCP1, subunit 4 (delta)-HPRD,BioGRID11580270 
CCT5CCT-epsilon | CCTE | KIAA0098 | TCP-1-epsilonchaperonin containing TCP1, subunit 5 (epsilon)-HPRD,BioGRID11580270 
CDH2CD325 | CDHN | CDw325 | NCADcadherin 2, type 1, N-cadherin (neuronal)Affinity Capture-WesternBioGRID12438242 
CFL1CFLcofilin 1 (non-muscle)Affinity Capture-MSBioGRID11950878 
-HPRD11707283 
CNN1SMCC | Sm-Calpcalponin 1, basic, smooth muscleReconstituted ComplexBioGRID2161834 
CSNK1A1CK1 | HLCDGP1 | PRO2975casein kinase 1, alpha 1Affinity Capture-MSBioGRID12062430 
DMDBMD | CMD3B | DXS142 | DXS164 | DXS206 | DXS230 | DXS239 | DXS268 | DXS269 | DXS270 | DXS272dystrophin-HPRD,BioGRID1544421|11259305 
-HPRD1544421 
DNASE1DKFZp686H0155 | DNL1 | DRNI | FLJ38093 | FLJ44902deoxyribonuclease I-HPRD11707283 
DNMBPKIAA1010 | TUBAdynamin binding protein-HPRD,BioGRID14506234 
DVL1L1DSH | DVL | DVL-22 | DVL1 | DVL4dishevelled, dsh homolog 1 (Drosophila)-like 1Affinity Capture-WesternBioGRID12384700 
EPB414.1R | EL1 | HEerythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)-HPRD11071908 
ETV6TEL | TEL/ABLets variant 6Co-localizationBioGRID9695962 
FGD4CMT4H | DKFZp313E1818 | DKFZp434K1572 | FLJ34370 | FLJ42663 | FRABP | MGC57222 | ZFYVE6FYVE, RhoGEF and PH domain containing 4-HPRD9668039 |11429692 
FSCN1FLJ38511 | SNL | p55fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)-HPRD,BioGRID8999969 
GAS7KIAA0394 | MGC1348 | MLL/GAS7growth arrest-specific 7-HPRD11795944 
GCDBP | DBP/GC | VDBG | VDBPgroup-specific component (vitamin D binding protein)Co-crystal StructureBioGRID12554937 
-HPRD12119014 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2Affinity Capture-MSBioGRID12577067 
GSNDKFZp313L0718gelsolin (amyloidosis, Finnish type)-HPRD,BioGRID10583954 
HIP1RFLJ14000 | FLJ27022 | HIP12 | HIP3 | ILWEQ | KIAA0655 | MGC47513huntingtin interacting protein 1 related-HPRD11889126 
JUBAjuba | MGC15563jub, ajuba homolog (Xenopus laevis)-HPRD12417594 
KLHL20KHLHX | KLEIP | KLHLX | RP3-383J4.3kelch-like 20 (Drosophila)-HPRD,BioGRID14668487 
MARK4FLJ90097 | KIAA1860 | MARKL1 | Nbla00650MAP/microtubule affinity-regulating kinase 4Affinity Capture-MSBioGRID14594945 
MIB2FLJ20648 | FLJ39787 | ZZANK1 | ZZZ5mindbomb homolog 2 (Drosophila)Reconstituted Complex
Two-hybrid		BioGRID14507647 
MLPHMGC2771 | MGC59733 | SLAC2-AmelanophilinAffinity Capture-WesternBioGRID15059972 
MYL1MLC1F | MLC3Fmyosin, light chain 1, alkali; skeletal, fast-HPRD11707283 
NRAP-nebulin-related anchoring proteinReconstituted ComplexBioGRID10320340 
PARVAFLJ10793 | FLJ12254 | MXRA2parvin, alpha-HPRD11171322 
PCYT1BCCT-beta | CTBphosphate cytidylyltransferase 1, choline, beta-HPRD,BioGRID11580270 
PFDN1PDF | PFD1prefoldin subunit 1Reconstituted ComplexBioGRID14634002 
PFN1-profilin 1-HPRD8413665 
PHACTR1KIAA1733 | MGC126575 | MGC126577 | RPEL | RPEL1 | dJ257A7.2phosphatase and actin regulator 1-HPRD,BioGRID15107502 
PLDNPA | PALLIDpallidin homolog (mouse)-HPRD12019270 
PPP1CAMGC15877 | MGC1674 | PP-1A | PPP1Aprotein phosphatase 1, catalytic subunit, alpha isoformAffinity Capture-WesternBioGRID15107502 
PPP1R9BFLJ30345 | PPP1R6 | PPP1R9 | SPINO | Spnprotein phosphatase 1, regulatory (inhibitor) subunit 9BReconstituted ComplexBioGRID12417592 
PRKCAAAG6 | MGC129900 | MGC129901 | PKC-alpha | PKCA | PRKACAprotein kinase C, alpha-HPRD,BioGRID10628374 
PRKCEMGC125656 | MGC125657 | PKCE | nPKC-epsilonprotein kinase C, epsilonAffinity Capture-MS
Affinity Capture-Western		BioGRID11897493 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-HPRD11027608 
RPS6KB1PS6K | S6K | S6K1 | STK14A | p70(S6K)-alpha | p70-S6K | p70-alpharibosomal protein S6 kinase, 70kDa, polypeptide 1Reconstituted ComplexBioGRID15149849 
S100A418A2 | 42A | CAPL | FSP1 | MTS1 | P9KA | PEL98S100 calcium binding protein A4-HPRD14640694 
SCINKIAA1905scinderinReconstituted ComplexBioGRID12438125 
TAGLNDKFZp686P11128 | SM22 | SMCC | TAGLN1 | WS3-10transgelin-HPRD,BioGRID11053353 
TESDKFZp586B2022 | MGC1146 | TESS | TESS-2testis derived transcript (3 LIM domains)Affinity Capture-WesternBioGRID12695497 
TLN1ILWEQ | KIAA1027 | TLNtalin 1-HPRD10581178 
TMSB4XFX | PTMB4 | TB4X | TMSB4thymosin beta 4, X-linked-HPRD,BioGRID11812134 
TMSB4YMGC26307 | TB4Ythymosin beta 4, Y-linkedReconstituted ComplexBioGRID8416954 
TNNI3CMD2A | CMH7 | MGC116817 | TNNC1 | cTnItroponin I type 3 (cardiac)-HPRD12383268 
TNNI3KCARK | MGC142099 | MGC33828TNNI3 interacting kinase-HPRD,BioGRID12721663 
TRAF3CAP-1 | CD40bp | CRAF1 | LAP1TNF receptor-associated factor 3-HPRD11950878 
TRIP6MGC10556 | MGC10558 | MGC29959 | MGC3837 | MGC4423 | OIP1 | ZRP-1thyroid hormone receptor interactor 6Co-localizationBioGRID14688263 
TSC1KIAA0243 | LAM | MGC86987 | TSCtuberous sclerosis 1Co-localizationBioGRID10806479 
VCLCMD1W | MVCLvinculin-HPRD7816144 
XIRP1CMYA1 | DKFZp451D042 | DKFZp779C1255 | DKFZp779C1947 | Xinxin actin-binding repeat containing 1-HPRD15454575 
XPO6EXP6 | FLJ22519 | KIAA0370 | RANBP20exportin 6Affinity Capture-MSBioGRID14592989 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
BIOCARTA_NO1_PATHWAY 3324All SZGR genes in this pathway
BIOCARTA_AGR_PATHWAY 3631All SZGR genes in this pathway
BIOCARTA_EPHA4_PATHWAY 108All SZGR genes in this pathway
BIOCARTA_SALMONELLA_PATHWAY 1310All SZGR genes in this pathway
BIOCARTA_MPR_PATHWAY 3428All SZGR genes in this pathway
BIOCARTA_INTEGRIN_PATHWAY 3829All SZGR genes in this pathway
BIOCARTA_MCALPAIN_PATHWAY 2516All SZGR genes in this pathway
BIOCARTA_NFAT_PATHWAY 5645All SZGR genes in this pathway
BIOCARTA_RAB_PATHWAY 128All SZGR genes in this pathway
BIOCARTA_MAL_PATHWAY 1917All SZGR genes in this pathway
BIOCARTA_MET_PATHWAY 3730All SZGR genes in this pathway
BIOCARTA_HSP27_PATHWAY 1511All SZGR genes in this pathway
BIOCARTA_UCALPAIN_PATHWAY 1811All SZGR genes in this pathway
BIOCARTA_ACTINY_PATHWAY 2014All SZGR genes in this pathway
PID_RHOA_PATHWAY 4533All SZGR genes in this pathway
PID_AP1_PATHWAY 7060All SZGR genes in this pathway
PID_CASPASE_PATHWAY 5239All SZGR genes in this pathway
PID_FAK_PATHWAY 5945All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_REVERSIBLY_DN 2921All SZGR genes in this pathway
MARKEY_RB1_CHRONIC_LOF_DN 11878All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_UP 536340All SZGR genes in this pathway
DARWICHE_SKIN_TUMOR_PROMOTER_DN 185115All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_LOW_DN 165107All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_HIGH_DN 180110All SZGR genes in this pathway
DARWICHE_SQUAMOUS_CELL_CARCINOMA_DN 181107All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
RICKMAN_HEAD_AND_NECK_CANCER_F 5432All SZGR genes in this pathway
BENPORATH_ES_1 379235All SZGR genes in this pathway
PENG_GLUCOSE_DEPRIVATION_UP 4826All SZGR genes in this pathway
BECKER_TAMOXIFEN_RESISTANCE_UP 5036All SZGR genes in this pathway
NING_CHRONIC_OBSTRUCTIVE_PULMONARY_DISEASE_UP 157105All SZGR genes in this pathway
YAO_HOXA10_TARGETS_VIA_PROGESTERONE_DN 1912All SZGR genes in this pathway
CROMER_METASTASIS_DN 8158All SZGR genes in this pathway
LU_AGING_BRAIN_DN 153120All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_NEOCORTEX_UP 8366All SZGR genes in this pathway
LEE_AGING_CEREBELLUM_DN 8666All SZGR genes in this pathway
DELASERNA_MYOD_TARGETS_UP 8951All SZGR genes in this pathway
CHEN_LVAD_SUPPORT_OF_FAILING_HEART_UP 10369All SZGR genes in this pathway
APRELIKOVA_BRCA1_TARGETS 4933All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_18HR_DN 178121All SZGR genes in this pathway
KUNINGER_IGF1_VS_PDGFB_TARGETS_UP 8251All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
SARRIO_EPITHELIAL_MESENCHYMAL_TRANSITION_DN 154101All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP 648398All SZGR genes in this pathway
MUELLER_PLURINET 299189All SZGR genes in this pathway
YAUCH_HEDGEHOG_SIGNALING_PARACRINE_DN 264159All SZGR genes in this pathway
WUNDER_INFLAMMATORY_RESPONSE_AND_CHOLESTEROL_DN 127All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
YAGI_AML_WITH_11Q23_REARRANGED 351238All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_14 14386All SZGR genes in this pathway
SASSON_RESPONSE_TO_GONADOTROPHINS_DN 8766All SZGR genes in this pathway
SASSON_RESPONSE_TO_FORSKOLIN_DN 8868All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
PASINI_SUZ12_TARGETS_DN 315215All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP 682433All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_10HR_UP 199143All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_DN 308187All SZGR genes in this pathway
CHEMELLO_SOLEUS_VS_EDL_MYOFIBERS_UP 3516All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/981631691Ahsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-1552232301A,m8hsa-miR-155UUAAUGCUAAUCGUGAUAGGGG
miR-262142201Ahsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-4951711771Ahsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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