Gene Page: CHRM3

Summary
GeneID  1131
Symbol  CHRM3
Synonyms  HM3
Description  cholinergic receptor, muscarinic 3
See related  HGNC:1952|MIM:118494|Ensembl:ENSG00000133019|HPRD:00329|
Locus tag  -
Gene type  protein-coding
Map location  1q43
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0018 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
MPP20.790.80
C9orf1250.750.77
TNFAIP10.750.74
PNMAL10.750.78
KLHDC50.740.77
SV2A0.740.80
SEMA4F0.730.73
PIP5K1C0.730.79
FAM53C0.730.78
PLEKHB20.720.77
Top 10 negatively co-expressed genes
AL139819.3-0.50-0.54
AF347015.21-0.46-0.45
AP002478.3-0.45-0.48
MT-CO2-0.45-0.44
NOSTRIN-0.45-0.45
AF347015.26-0.44-0.38
AF347015.18-0.44-0.45
MT-CYB-0.44-0.43
AF347015.8-0.44-0.44
GNG11-0.44-0.45
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityTAS10940357 
GO:0004981muscarinic acetylcholine receptor activityTAS9547368 
GO:0004435phosphoinositide phospholipase C activityTAS1905013 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007399nervous system developmentTASneurite (GO term level: 5)2739737 
GO:0007186G-protein coupled receptor protein signaling pathwayTAS9603968 
GO:0006464protein modification processTAS10051746 
GO:0007165signal transductionTAS10940357 
GO:0008283cell proliferationTAS8063729 
GO:0007586digestionIEA-
GO:0045987positive regulation of smooth muscle contractionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0045211postsynaptic membraneIEASynap, Neurotransmitter (GO term level: 5)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0005886plasma membraneTAS9547368 
GO:0005887integral to plasma membraneTAS3443095 
GO:0016323basolateral plasma membraneIEA-
GO:0030054cell junctionIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARF1-ADP-ribosylation factor 1Affinity Capture-Western
Reconstituted Complex		BioGRID12799371 
ARF6DKFZp564M0264ADP-ribosylation factor 6-HPRD,BioGRID12799371 
CSNK1A1CK1 | HLCDGP1 | PRO2975casein kinase 1, alpha 1-HPRD,BioGRID10777483 
GNAQG-ALPHA-q | GAQguanine nucleotide binding protein (G protein), q polypeptide-HPRD7629074 
GRK6FLJ32135 | GPRK6G protein-coupled receptor kinase 6-HPRD11856737 
GZMBCCPI | CGL-1 | CGL1 | CSP-B | CSPB | CTLA1 | CTSGL1 | HLP | SECTgranzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)-HPRD,BioGRID11665980 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CALCIUM_SIGNALING_PATHWAY 178134All SZGR genes in this pathway
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK 205136All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS 305177All SZGR genes in this pathway
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 12084All SZGR genes in this pathway
REACTOME_AMINE_LIGAND_BINDING_RECEPTORS 3833All SZGR genes in this pathway
REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS 184116All SZGR genes in this pathway
REACTOME_REGULATION_OF_INSULIN_SECRETION 9365All SZGR genes in this pathway
REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE 119All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_WITH_LMP1_UP 408247All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_DN 367220All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
LANDEMAINE_LUNG_METASTASIS 2112All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_UP 295149All SZGR genes in this pathway
ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN 940425All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BONE_DN 315197All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP 648398All SZGR genes in this pathway
CHANDRAN_METASTASIS_DN 306191All SZGR genes in this pathway
HOELZEL_NF1_TARGETS_UP 13993All SZGR genes in this pathway
BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN 8861All SZGR genes in this pathway


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