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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Gene Page: CDC42

Summary

GeneID

998

Symbol

CDC42

Synonyms

CDC42Hs|G25K

Description

cell division cycle 42 (GTP binding protein, 25kDa)

Locus tag

RP1-224A6.5

Gene type

protein-coding

Map location

1p36.1

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 3

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 1.1845

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

ROBO4

0.84

0.83

MMRN2

0.81

0.83

TIE1

0.81

0.80

CXorf36

0.79

0.81

ENG

0.79

0.82

FLI1

0.77

GPR124

0.77

0.80

TNFRSF1B

0.76

0.79

FGD5

0.76

0.81

NOS3

0.76

0.78

Top 10 negatively co-expressed genes

MTIF3

-0.51

-0.53

TIMM10

-0.50

-0.51

C8orf59

-0.46

-0.55

TMEM126A

-0.46

-0.51

COX7C

-0.45

-0.50

USMG5

-0.45

-0.58

ST20

-0.45

-0.50

MRPL21

-0.45

-0.48

ZBTB8OS

-0.45

-0.47

MRPS18C

-0.45

-0.50

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000166

nucleotide binding

IEA

GO:0003924

GTPase activity

IEA

GO:0003924

GTPase activity

TAS

11035016

GO:0005515

protein binding

IPI

10587647 |10816584 |11035016

GO:0005525

GTP binding

IEA

GO:0030742

GTP-dependent protein binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0046847

filopodium formation

IEA

axon (GO term level: 10)

GO:0007163

establishment or maintenance of cell polarity

TAS

11260256

GO:0007097

nuclear migration

IEA

GO:0007264

small GTPase mediated signal transduction

IEA

GO:0030036

actin cytoskeleton organization

IDA

11035016

GO:0031333

negative regulation of protein complex assembly

IPI

11584266

GO:0031274

positive regulation of pseudopodium formation

IDA

11035016

GO:0051301

cell division

IEA

GO:0030225

macrophage differentiation

TAS

11260256

GO:0043552

positive regulation of phosphoinositide 3-kinase activity

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0030175

filopodium

IDA

axon (GO term level: 5)

11035016

GO:0042995

cell projection

IEA

axon (GO term level: 4)

GO:0005829

cytosol

EXP

14505571 |16407834

GO:0005622

intracellular

IEA

GO:0005737

cytoplasm

IDA

11260256

GO:0005886

plasma membrane

IDA

11260256

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACTR3	ARP3	ARP3 actin-related protein 3 homolog (yeast)	-	HPRD	9860974
ARHGAP1	CDC42GAP \| RHOGAP \| RHOGAP1 \| p50rhoGAP	Rho GTPase activating protein 1	-	HPRD,BioGRID	9268338
ARHGAP1	CDC42GAP \| RHOGAP \| RHOGAP1 \| p50rhoGAP	Rho GTPase activating protein 1	Cdc42GAP interacts with Cdc42. This interaction was modelled on a demonstrated interaction between human Cdc42GAP and Cdc42 from an unspecified species.	BIND	10799524
ARHGAP10	FLJ20896 \| FLJ41791 \| GRAF2 \| PS-GAP	Rho GTPase activating protein 10	Biochemical Activity	BioGRID	11432776
ARHGAP17	DKFZp564A1363 \| FLJ37567 \| FLJ43368 \| MGC87805 \| MST066 \| MST110 \| MSTP038 \| MSTP066 \| MSTP110 \| NADRIN \| RICH1 \| WBP15	Rho GTPase activating protein 17	Biochemical Activity	BioGRID	11431473
ARHGAP26	FLJ42530 \| GRAF \| KIAA0621 \| OPHN1L \| OPHN1L1	Rho GTPase activating protein 26	Biochemical Activity	BioGRID	11432776
ARHGAP27	CAMGAP1 \| FLJ43547 \| MGC120624	Rho GTPase activating protein 27	Biochemical Activity	BioGRID	15147912
ARHGAP29	PARG1 \| RP11-255E17.1	Rho GTPase activating protein 29	Two-hybrid	BioGRID	14749388
ARHGAP8	BPGAP1 \| FLJ20185 \| PP610	Rho GTPase activating protein 8	BPGAP1 interacts with Cdc42.	BIND	12944407
ARHGDIA	GDIA1 \| MGC117248 \| RHOGDI \| RHOGDI-1	Rho GDP dissociation inhibitor (GDI) alpha	-	HPRD	10676816
ARHGDIA	GDIA1 \| MGC117248 \| RHOGDI \| RHOGDI-1	Rho GDP dissociation inhibitor (GDI) alpha	Affinity Capture-MS	BioGRID	17353931
ARHGDIB	D4 \| GDIA2 \| GDID4 \| LYGDI \| Ly-GDI \| RAP1GN1 \| RhoGDI2	Rho GDP dissociation inhibitor (GDI) beta	-	HPRD,BioGRID	9799233
ARHGDIG	RHOGDI-3	Rho GDP dissociation inhibitor (GDI) gamma	-	HPRD,BioGRID	9113980
ARHGEF6	COOL2 \| Cool-2 \| KIAA0006 \| MRX46 \| PIXA \| alpha-PIX \| alphaPIX	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	ARHGEF6 (Cool-2) interacts with Cdc42.	BIND	15649357
ARHGEF7	BETA-PIX \| COOL1 \| DKFZp686C12170 \| DKFZp761K1021 \| KIAA0142 \| KIAA0412 \| Nbla10314 \| P50 \| P50BP \| P85 \| P85COOL1 \| P85SPR \| PAK3 \| PIXB	Rho guanine nucleotide exchange factor (GEF) 7	ARHGEF7 (p85Cool-1) interacts with Cdc42.	BIND	15649357
BAIAP2	BAP2 \| IRSP53	BAI1-associated protein 2	-	HPRD,BioGRID	11696321
BNIP2	BNIP-2 \| NIP2	BCL2/adenovirus E1B 19kDa interacting protein 2	BNIP-2 interacts with an unspecified isoform of Cdc42. This interaction was modeled on a demonstrated interaction between human BNIP-2 and Cdc42 from an unspecified species.	BIND	10954711
			BNIP-2 interacts with an unspecified isoform of Cdc42.	BIND	15652341
			BNIP-2 interacts with Cdc42. This interaction was modelled on a demonstrated interaction between human BNIP-2 and Cdc42 from an unspecified species.	BIND	10799524
			-	HPRD,BioGRID	10551883 \|10799524 \|10954711
BNIPL	BNIP-S \| BNIPL-1 \| BNIPL-2 \| BNIPL1 \| BNIPL2 \| PP753	BCL2/adenovirus E1B 19kD interacting protein like	Affinity Capture-Western Two-hybrid	BioGRID	12901880
C14orf1	ERG28 \| NET51	chromosome 14 open reading frame 1	Two-hybrid	BioGRID	16169070
C1orf103	FLJ11269 \| RIF1 \| RP11-96K19.1	chromosome 1 open reading frame 103	Two-hybrid	BioGRID	16169070
CDC42	CDC42Hs \| G25K	cell division cycle 42 (GTP binding protein, 25kDa)	-	HPRD,BioGRID	10211824
CDC42BPG	DMPK2 \| HSMDPKIN \| KAPPA-200 \| MRCKgamma	CDC42 binding protein kinase gamma (DMPK-like)	-	HPRD,BioGRID	15194684
CDC42EP1	BORG5 \| CEP1 \| MGC15316 \| MSE55	CDC42 effector protein (Rho GTPase binding) 1	Two-hybrid	BioGRID	16189514
CDC42EP2	BORG1 \| CEP2	CDC42 effector protein (Rho GTPase binding) 2	-	HPRD,BioGRID	11035016
CDC42EP2	BORG1 \| CEP2	CDC42 effector protein (Rho GTPase binding) 2	Activated Cdc42 interacts with Borg1. This interaction was modeled on a demonstrated interaction between Cdc42 from an unspecified species and Borg1 from human.	BIND	10490598
CDC42EP3	BORG2 \| CEP3 \| FLJ46903 \| UB1	CDC42 effector protein (Rho GTPase binding) 3	Activated Cdc42 interacts with Borg2. This interaction was modeled on a demonstrated interaction between Cdc42 from an unspecified species and Borg2 from human.	BIND	10490598
CDC42EP3	BORG2 \| CEP3 \| FLJ46903 \| UB1	CDC42 effector protein (Rho GTPase binding) 3	-	HPRD,BioGRID	10490598
CDC42EP5	Borg3 \| CEP5 \| MGC21945 \| MGC71153	CDC42 effector protein (Rho GTPase binding) 5	-	HPRD,BioGRID	10490598 \|11035016 \|11584266\|11035016
CDC42SE1	SCIP1 \| SPEC1	CDC42 small effector 1	-	HPRD,BioGRID	10816584
CDC42SE2	FLJ21967 \| SPEC2	CDC42 small effector 2	Two-hybrid	BioGRID	10816584
CDGAP	KIAA1204 \| MGC138368 \| MGC138370	Cdc42 GTPase-activating protein	-	HPRD	9786927
CLIP1	CLIP \| CLIP-170 \| CLIP170 \| CYLN1 \| MGC131604 \| RSN	CAP-GLY domain containing linker protein 1	Affinity Capture-Western	BioGRID	12110184
CSPG4	HMW-MAA \| MCSP \| MCSPG \| MEL-CSPG \| MSK16 \| NG2	chondroitin sulfate proteoglycan 4	-	HPRD,BioGRID	10587647
DEF6	IBP \| SLAT	differentially expressed in FDCP 6 homolog (mouse)	-	HPRD,BioGRID	15023524
DEF6	IBP \| SLAT	differentially expressed in FDCP 6 homolog (mouse)	DEF6 interacts with Cdc42. This interaction was modelled on a demonstrated interaction between human DEF6 and Cdc42 from an unspecified species.	BIND	15023524
DOCK7	KIAA1771 \| ZIR2	dedicator of cytokinesis 7	-	HPRD	12432077
DOCK8	FLJ00026 \| FLJ00152 \| FLJ00346 \| MRD2 \| ZIR8	dedicator of cytokinesis 8	-	HPRD,BioGRID	15304341
DOCK9	DKFZp686C11110 \| DKFZp686D2047 \| DKFZp686N04132 \| FLJ11949 \| FLJ16744 \| FLJ44528 \| FLJ45282 \| FLJ45601 \| KIAA1058 \| KIAA1085 \| ZIZ1 \| ZIZIMIN1	dedicator of cytokinesis 9	-	HPRD,BioGRID	12172552
EEF1G	EF1G \| GIG35	eukaryotic translation elongation factor 1 gamma	Two-hybrid	BioGRID	16169070
EIF2AK2	EIF2AK1 \| MGC126524 \| PKR \| PRKR	eukaryotic translation initiation factor 2-alpha kinase 2	-	HPRD	7738010
ERRFI1	GENE-33 \| MIG-6 \| MIG6 \| RALT	ERBB receptor feedback inhibitor 1	Affinity Capture-Western Reconstituted Complex	BioGRID	10749885
FGD1	AAS \| FGDY \| ZFYVE3	FYVE, RhoGEF and PH domain containing 1	-	HPRD,BioGRID	8969170
FLNA	ABP-280 \| ABPX \| DKFZp434P031 \| FLN \| FLN1 \| FMD \| MNS \| NHBP \| OPD \| OPD1 \| OPD2	filamin A, alpha (actin binding protein 280)	-	HPRD	10051605
FNBP1L	C1orf39 \| TOCA1	formin binding protein 1-like	Affinity Capture-Western	BioGRID	15260990
GDI1	FLJ41411 \| GDIL \| MRX41 \| MRX48 \| OPHN2 \| RABGD1A \| RABGDIA \| XAP-4	GDP dissociation inhibitor 1	-	HPRD,BioGRID	11583574
GEFT	p63RhoGEF	RhoA/RAC/CDC42 exchange factor	-	HPRD,BioGRID	12547822
GOPC	CAL \| FIG \| GOPC1 \| PIST \| dJ94G16.2	golgi associated PDZ and coiled-coil motif containing	Reconstituted Complex	BioGRID	11162552
IQGAP1	HUMORFA01 \| KIAA0051 \| SAR1 \| p195	IQ motif containing GTPase activating protein 1	-	HPRD	8670801 \|12900413\|8798539 \|9182573
IQGAP1	HUMORFA01 \| KIAA0051 \| SAR1 \| p195	IQ motif containing GTPase activating protein 1	Affinity Capture-Western in vitro in vivo Reconstituted Complex	BioGRID	8670801 \|8798539 \|9182573 \|12110184
IQGAP2	-	IQ motif containing GTPase activating protein 2	-	HPRD	8756646
IQGAP2	-	IQ motif containing GTPase activating protein 2	-	HPRD,BioGRID	8702968 \|8756646\|8756646
ITSN1	ITSN \| MGC134948 \| MGC134949 \| SH3D1A \| SH3P17	intersectin 1 (SH3 domain protein)	Cdc42 specifically interacts with Dbl-homology and pleckstrin-homology domains of the nucleotide exchange factor ITSN1.	BIND	12006984
ITSN1	ITSN \| MGC134948 \| MGC134949 \| SH3D1A \| SH3P17	intersectin 1 (SH3 domain protein)	-	HPRD,BioGRID	11584276
KAT5	ESA1 \| HTATIP \| HTATIP1 \| PLIP \| TIP \| TIP60 \| cPLA2	K(lysine) acetyltransferase 5	Two-hybrid	BioGRID	16169070
KTN1	CG1 \| KIAA0004 \| KNT \| MGC133337 \| MU-RMS-40.19	kinectin 1 (kinesin receptor)	-	HPRD	9535835
MAP3K10	MLK2 \| MST	mitogen-activated protein kinase kinase kinase 10	-	HPRD,BioGRID	9427749
MAP3K11	MGC17114 \| MLK-3 \| MLK3 \| PTK1 \| SPRK	mitogen-activated protein kinase kinase kinase 11	-	HPRD,BioGRID	10799501
MAP3K4	FLJ42439 \| KIAA0213 \| MAPKKK4 \| MEKK4 \| MTK1 \| PRO0412	mitogen-activated protein kinase kinase kinase 4	-	HPRD,BioGRID	9079650
MCF2	DBL	MCF.2 cell line derived transforming sequence	Reconstituted Complex	BioGRID	10854437
MCF2L	ARHGEF14 \| DBS \| FLJ12122 \| KIAA0362 \| OST	MCF.2 cell line derived transforming sequence-like	Cdc42 specifically interacts with Dbl-homology and pleckstrin-homology domains of the nucleotide exchange factor Dbs. This interaction is modelled on a demonstrated interaction between mouse Dbs and human Cdc42.	BIND	11889037
MCF2L	ARHGEF14 \| DBS \| FLJ12122 \| KIAA0362 \| OST	MCF.2 cell line derived transforming sequence-like	-	HPRD,BioGRID	14701795
METAP2	MAP2 \| MNPEP \| p67 \| p67eIF2	methionyl aminopeptidase 2	-	HPRD	7738010
NCF2	FLJ93058 \| NCF-2 \| NOXA2 \| P67-PHOX \| P67PHOX	neutrophil cytosolic factor 2	-	HPRD,BioGRID	7738010 \|9642115\|9642115
NCF2	FLJ93058 \| NCF-2 \| NOXA2 \| P67-PHOX \| P67PHOX	neutrophil cytosolic factor 2	-	HPRD	9642115
OPHN1	MRX60 \| OPN1	oligophrenin 1	-	HPRD,BioGRID	9582072 \|11998687
PAK1	MGC130000 \| MGC130001 \| PAKalpha	p21 protein (Cdc42/Rac)-activated kinase 1	Reconstituted Complex	BioGRID	12650940
			PAK1 interacts with an unspecified isoform of Cdc42. This interaction was modeled on a demonstrated interaction between PAK1 from an unspecified species and human Cdc42.	BIND	15864311
			-	HPRD	7744004 \|8107774 \|9705280\|9705280
			Cdc42 interacts with Pak1. This interaction was modelled on a demonstrated interaction between Cdc42 from an unspecified species and human Pak1.	BIND	12944407
PAK2	PAK65 \| PAKgamma	p21 protein (Cdc42/Rac)-activated kinase 2	-	HPRD,BioGRID	10320322
PAK4	-	p21 protein (Cdc42/Rac)-activated kinase 4	-	HPRD,BioGRID	9822598
PAK6	PAK5	p21 protein (Cdc42/Rac)-activated kinase 6	-	HPRD,BioGRID	11773441
PAK7	KIAA1264 \| MGC26232 \| PAK5	p21 protein (Cdc42/Rac)-activated kinase 7	-	HPRD,BioGRID	11756552 \|12032833
PARD3	ASIP \| Baz \| Bazooka \| FLJ21015 \| PAR3 \| PAR3alpha \| PARD3A \| SE2-5L16 \| SE2-5LT1 \| SE2-5T2	par-3 partitioning defective 3 homolog (C. elegans)	-	HPRD	10934474
PARD6A	PAR-6A \| PAR6 \| PAR6C \| PAR6alpha \| TAX40 \| TIP-40	par-6 partitioning defective 6 homolog alpha (C. elegans)	Affinity Capture-Western in vitro in vivo Reconstituted Complex Two-hybrid	BioGRID	10873802 \|10934474 \|11260256
PARD6A	PAR-6A \| PAR6 \| PAR6C \| PAR6alpha \| TAX40 \| TIP-40	par-6 partitioning defective 6 homolog alpha (C. elegans)	-	HPRD	10873802\|11260256
PARD6B	PAR6B	par-6 partitioning defective 6 homolog beta (C. elegans)	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	10934474 \|11162552
PARD6G	FLJ45701 \| PAR-6G \| PAR6gamma	par-6 partitioning defective 6 homolog gamma (C. elegans)	-	HPRD,BioGRID	11260256
PDE6D	PDED	phosphodiesterase 6D, cGMP-specific, rod, delta	Two-hybrid	BioGRID	16169070
PIK3R1	GRB1 \| p85 \| p85-ALPHA	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	-	HPRD,BioGRID	7629060 \|8034624 \|9381982
PIK3R1	GRB1 \| p85 \| p85-ALPHA	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	-	HPRD	9381982
PLD1	-	phospholipase D1, phosphatidylcholine-specific	-	HPRD,BioGRID	10747870
PLEKHG2	CLG \| DKFZp667J2325 \| FLJ00018 \| FLJ22458 \| FLJ38638	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	-	HPRD,BioGRID	11839748
PRKCA	AAG6 \| MGC129900 \| MGC129901 \| PKC-alpha \| PKCA \| PRKACA	protein kinase C, alpha	-	HPRD,BioGRID	11284700
PRKCZ	PKC-ZETA \| PKC2	protein kinase C, zeta	-	HPRD	10733591
RAC1	MGC111543 \| MIG5 \| TC-25 \| p21-Rac1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	Two-hybrid	BioGRID	9427749
RAC2	EN-7 \| Gx \| HSPC022	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	-	HPRD,BioGRID	9748241
RHOJ	ARHJ \| FLJ14445 \| MGC34777 \| RASL7B \| TC10B \| TCL	ras homolog gene family, member J	-	HPRD,BioGRID	10967094
RICH2	KIAA0672 \| NPC-A-10	Rho-type GTPase-activating protein RICH2	Biochemical Activity	BioGRID	11431473
RICS	GC-GAP \| GRIT \| KIAA0712 \| MGC1892 \| p200RhoGAP \| p250GAP	Rho GTPase-activating protein	Biochemical Activity	BioGRID	12446789 \|12819203 \|12857875
RPS6KB1	PS6K \| S6K \| S6K1 \| STK14A \| p70(S6K)-alpha \| p70-S6K \| p70-alpha	ribosomal protein S6 kinase, 70kDa, polypeptide 1	-	HPRD	11438723
SRGAP1	ARHGAP13 \| FLJ22166 \| KIAA1304	SLIT-ROBO Rho GTPase activating protein 1	-	HPRD	11672528
TBC1D3	TBC1D3A \| TRE17	TBC1 domain family, member 3	-	HPRD,BioGRID	12612085
TNK2	ACK \| ACK1 \| FLJ44758 \| FLJ45547 \| p21cdc42Hs	tyrosine kinase, non-receptor, 2	-	HPRD,BioGRID	11394904
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	Two-hybrid	BioGRID	16169070
TRIP10	CIP4 \| HSTP \| STOT \| STP	thyroid hormone receptor interactor 10	-	HPRD,BioGRID	9210375 \|10713100
UBR1	JBS \| MGC142065 \| MGC142067	ubiquitin protein ligase E3 component n-recognin 1	Two-hybrid	BioGRID	16169070
UNC119	HRG4	unc-119 homolog (C. elegans)	Two-hybrid	BioGRID	16169070
VAV1	VAV	vav 1 guanine nucleotide exchange factor	-	HPRD,BioGRID	11287617
WAS	IMD2 \| THC \| WASP	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	CDC42 interacts with WASP. This interaction was modeled on a demonstrated interaction between CDC42 and WASP from an unspecified species.	BIND	15652748
			Active GTP-bound CDC42 interacts with WAS (WASP). This interaction was modelled on a demonstrated interaction between chicken CDC42 and human WAS.	BIND	15735674
			Cdc42 interacts with WASP.	BIND	15361624
			-	HPRD	8625410 \|10724160
			in vitro in vivo Reconstituted Complex	BioGRID	8625410 \|8643625 \|10713100 \|10724160
WASF1	FLJ31482 \| KIAA0269 \| SCAR1 \| WAVE \| WAVE1	WAS protein family, member 1	-	HPRD	12181570
WASF2	SCAR2 \| WAVE2 \| dJ393P12.2	WAS protein family, member 2	-	HPRD	12181570
WASL	DKFZp779G0847 \| MGC48327 \| N-WASP \| NWASP	Wiskott-Aldrich syndrome-like	in vitro Reconstituted Complex	BioGRID	9422512 \|10781580
WASL	DKFZp779G0847 \| MGC48327 \| N-WASP \| NWASP	Wiskott-Aldrich syndrome-like	-	HPRD	9422512 \|10724160

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_MAPK_SIGNALING_PATHWAY	267	205	All SZGR genes in this pathway
KEGG_CHEMOKINE_SIGNALING_PATHWAY	190	128	All SZGR genes in this pathway
KEGG_ENDOCYTOSIS	183	132	All SZGR genes in this pathway
KEGG_AXON_GUIDANCE	129	103	All SZGR genes in this pathway
KEGG_VEGF_SIGNALING_PATHWAY	76	53	All SZGR genes in this pathway
KEGG_FOCAL_ADHESION	201	138	All SZGR genes in this pathway
KEGG_ADHERENS_JUNCTION	75	53	All SZGR genes in this pathway
KEGG_TIGHT_JUNCTION	134	86	All SZGR genes in this pathway
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY	108	89	All SZGR genes in this pathway
KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS	97	71	All SZGR genes in this pathway
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	118	78	All SZGR genes in this pathway
KEGG_NEUROTROPHIN_SIGNALING_PATHWAY	126	103	All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON	216	144	All SZGR genes in this pathway
KEGG_GNRH_SIGNALING_PATHWAY	101	77	All SZGR genes in this pathway
KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	68	44	All SZGR genes in this pathway
KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION	59	36	All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER	328	259	All SZGR genes in this pathway
KEGG_RENAL_CELL_CARCINOMA	70	60	All SZGR genes in this pathway
KEGG_PANCREATIC_CANCER	70	56	All SZGR genes in this pathway
BIOCARTA_AGR_PATHWAY	36	31	All SZGR genes in this pathway
BIOCARTA_SALMONELLA_PATHWAY	13	10	All SZGR genes in this pathway
BIOCARTA_P38MAPK_PATHWAY	40	31	All SZGR genes in this pathway
BIOCARTA_RAS_PATHWAY	23	20	All SZGR genes in this pathway
BIOCARTA_MAL_PATHWAY	19	17	All SZGR genes in this pathway
BIOCARTA_CDC42RAC_PATHWAY	16	13	All SZGR genes in this pathway
SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	67	54	All SZGR genes in this pathway
SIG_CHEMOTAXIS	45	37	All SZGR genes in this pathway
ST_P38_MAPK_PATHWAY	37	28	All SZGR genes in this pathway
SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	35	25	All SZGR genes in this pathway
ST_INTEGRIN_SIGNALING_PATHWAY	82	62	All SZGR genes in this pathway
ST_GA13_PATHWAY	37	32	All SZGR genes in this pathway
SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	51	41	All SZGR genes in this pathway
ST_JNK_MAPK_PATHWAY	40	30	All SZGR genes in this pathway
PID_ENDOTHELIN_PATHWAY	63	52	All SZGR genes in this pathway
PID_RHOA_PATHWAY	45	33	All SZGR genes in this pathway
PID_WNT_NONCANONICAL_PATHWAY	32	26	All SZGR genes in this pathway
PID_TCR_PATHWAY	66	51	All SZGR genes in this pathway
PID_MET_PATHWAY	80	60	All SZGR genes in this pathway
PID_EPHB_FWD_PATHWAY	40	38	All SZGR genes in this pathway
PID_AVB3_OPN_PATHWAY	31	29	All SZGR genes in this pathway
PID_S1P_S1P4_PATHWAY	14	11	All SZGR genes in this pathway
PID_ILK_PATHWAY	45	32	All SZGR genes in this pathway
PID_NECTIN_PATHWAY	30	20	All SZGR genes in this pathway
PID_P38_ALPHA_BETA_PATHWAY	31	25	All SZGR genes in this pathway
PID_CDC42_PATHWAY	70	51	All SZGR genes in this pathway
PID_CDC42_REG_PATHWAY	30	22	All SZGR genes in this pathway
PID_NETRIN_PATHWAY	32	27	All SZGR genes in this pathway
PID_CXCR4_PATHWAY	102	78	All SZGR genes in this pathway
PID_AJDISS_2PATHWAY	48	38	All SZGR genes in this pathway
PID_ECADHERIN_NASCENT_AJ_PATHWAY	39	33	All SZGR genes in this pathway
PID_LIS1_PATHWAY	28	22	All SZGR genes in this pathway
PID_ERBB1_DOWNSTREAM_PATHWAY	105	78	All SZGR genes in this pathway
PID_ERBB2_ERBB3_PATHWAY	44	35	All SZGR genes in this pathway
PID_TRKR_PATHWAY	62	48	All SZGR genes in this pathway
PID_AR_NONGENOMIC_PATHWAY	31	27	All SZGR genes in this pathway
PID_ERBB1_INTERNALIZATION_PATHWAY	41	35	All SZGR genes in this pathway
PID_VEGFR1_2_PATHWAY	69	57	All SZGR genes in this pathway
PID_NCADHERIN_PATHWAY	33	32	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_RHO_GTPASES	113	81	All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY	396	292	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_EGFR_IN_CANCER	109	80	All SZGR genes in this pathway
REACTOME_EGFR_DOWNREGULATION	25	14	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR	920	449	All SZGR genes in this pathway
REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE	31	25	All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE	251	188	All SZGR genes in this pathway
REACTOME_G_ALPHA1213_SIGNALLING_EVENTS	74	56	All SZGR genes in this pathway
REACTOME_CD28_CO_STIMULATION	32	26	All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING	805	368	All SZGR genes in this pathway
REACTOME_CD28_DEPENDENT_VAV1_PATHWAY	11	10	All SZGR genes in this pathway
REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING	32	22	All SZGR genes in this pathway
REACTOME_SEMAPHORIN_INTERACTIONS	68	53	All SZGR genes in this pathway
REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE	27	21	All SZGR genes in this pathway
REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY	63	48	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ROBO_RECEPTOR	30	26	All SZGR genes in this pathway
REACTOME_MYOGENESIS	28	20	All SZGR genes in this pathway
REACTOME_NETRIN1_SIGNALING	41	30	All SZGR genes in this pathway
REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING	13	11	All SZGR genes in this pathway
REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION	132	101	All SZGR genes in this pathway
REACTOME_HEMOSTASIS	466	331	All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM	933	616	All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM	539	350	All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION	208	138	All SZGR genes in this pathway
WATANABE_COLON_CANCER_MSI_VS_MSS_DN	81	42	All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN	493	298	All SZGR genes in this pathway
GARY_CD5_TARGETS_UP	473	314	All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN	320	184	All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_DN	241	146	All SZGR genes in this pathway
WANG_LMO4_TARGETS_DN	352	225	All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_UP	78	48	All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_DN	205	127	All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_DN	260	143	All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_DN	536	332	All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_UP	557	331	All SZGR genes in this pathway
HAHTOLA_MYCOSIS_FUNGOIDES_CD4_DN	116	71	All SZGR genes in this pathway
HAHTOLA_MYCOSIS_FUNGOIDES_DN	16	10	All SZGR genes in this pathway
COLDREN_GEFITINIB_RESISTANCE_DN	230	115	All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_DN	64	39	All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_DN	75	50	All SZGR genes in this pathway
LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN	800	473	All SZGR genes in this pathway
LI_LUNG_CANCER	41	30	All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP	479	299	All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP	1037	673	All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN	1024	594	All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP	811	508	All SZGR genes in this pathway
LOPEZ_MBD_TARGETS	957	597	All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX	795	478	All SZGR genes in this pathway
CAFFAREL_RESPONSE_TO_THC_24HR_3_DN	13	8	All SZGR genes in this pathway
CAFFAREL_RESPONSE_TO_THC_24HR_5_DN	59	35	All SZGR genes in this pathway
BENPORATH_CYCLING_GENES	648	385	All SZGR genes in this pathway
SAKAI_TUMOR_INFILTRATING_MONOCYTES_DN	81	51	All SZGR genes in this pathway
ROZANOV_MMP14_TARGETS_UP	266	171	All SZGR genes in this pathway
IGLESIAS_E2F_TARGETS_UP	151	103	All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_UP	240	152	All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR	544	307	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN	1237	837	All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_DN	371	218	All SZGR genes in this pathway
YIH_RESPONSE_TO_ARSENITE_C4	18	12	All SZGR genes in this pathway
JIANG_HYPOXIA_NORMAL	311	205	All SZGR genes in this pathway
LEE_AGING_MUSCLE_UP	45	33	All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_DN	270	181	All SZGR genes in this pathway
OUYANG_PROSTATE_CANCER_PROGRESSION_UP	20	14	All SZGR genes in this pathway
BONCI_TARGETS_OF_MIR15A_AND_MIR16_1	91	75	All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_UP	374	247	All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN	366	257	All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK	1210	725	All SZGR genes in this pathway
HAHTOLA_CTCL_CUTANEOUS	26	19	All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_30MIN_DN	150	99	All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_M_G1	148	95	All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_NEURAL	129	85	All SZGR genes in this pathway
CHICAS_RB1_TARGETS_SENESCENT	572	352	All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN	1972	1213	All SZGR genes in this pathway
IKEDA_MIR133_TARGETS_UP	43	27	All SZGR genes in this pathway
KRIEG_KDM3A_TARGETS_NOT_HYPOXIA	208	107	All SZGR genes in this pathway
LIU_IL13_MEMORY_MODEL_UP	17	12	All SZGR genes in this pathway
ABDELMOHSEN_ELAVL4_TARGETS	16	13	All SZGR genes in this pathway
SMIRNOV_RESPONSE_TO_IR_6HR_UP	166	97	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-1/206	534	541	1A,m8	hsa-miR-1	UGGAAUGUAAAGAAGUAUGUA
				hsa-miR-206^SZ	UGGAAUGUAAGGAAGUGUGUGG
				hsa-miR-613	AGGAAUGUUCCUUCUUUGCC
miR-128	744	750	1A	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	744	750	1A	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-133	1117	1123	m8	hsa-miR-133a	UUGGUCCCCUUCAACCAGCUGU
miR-133	1117	1123	m8	hsa-miR-133b	UUGGUCCCCUUCAACCAGCUA
miR-137	50	56	m8	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-141/200a	1237	1243	1A	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	1237	1243	1A	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-18	837	843	m8	hsa-miR-18a	UAAGGUGCAUCUAGUGCAGAUA
miR-18	837	843	m8	hsa-miR-18b	UAAGGUGCAUCUAGUGCAGUUA
miR-185	647	654	1A,m8	hsa-miR-185^brain	UGGAGAGAAAGGCAGUUC
miR-186	1389	1395	m8	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-224	747	753	m8	hsa-miR-224	CAAGUCACUAGUGGUUCCGUUUA
miR-25/32/92/363/367	97	103	1A	hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
miR-27	744	750	m8	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	744	750	m8	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-29	578	584	m8	hsa-miR-29a^SZ	UAGCACCAUCUGAAAUCGGUU
				hsa-miR-29b^SZ	UAGCACCAUUUGAAAUCAGUGUU
				hsa-miR-29c^SZ	UAGCACCAUUUGAAAUCGGU
miR-299-3p	125	131	m8	hsa-miR-299-3p	UAUGUGGGAUGGUAAACCGCUU
miR-342	138	145	1A,m8	hsa-miR-342^brain	UCUCACACAGAAAUCGCACCCGUC
miR-381	1379	1385	1A	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.