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Gene Page: PRKCZ

Summary

GeneID

5590

Symbol

PRKCZ

Synonyms

PKC-ZETA|PKC2

Description

protein kinase C, zeta

Locus tag

Gene type

protein-coding

Map location

1p36.33-p36.2

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 1

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 1.9141

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000166

nucleotide binding

IEA

GO:0004700

atypical protein kinase C activity

TAS

8224878

GO:0005515

protein binding

IPI

11755531 |12893243

GO:0005524

ATP binding

IEA

GO:0016740

transferase activity

IEA

GO:0008270

zinc ion binding

IEA

GO:0019992

diacylglycerol binding

IEA

GO:0046872

metal ion binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000226

microtubule cytoskeleton organization

IEA

GO:0006468

protein amino acid phosphorylation

TAS

10477520

GO:0007242

intracellular signaling cascade

IEA

GO:0006916

anti-apoptosis

TAS

10770953

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005923

tight junction

IEA

Brain (GO term level: 10)

GO:0005624

membrane fraction

TAS

7925449

GO:0005737

cytoplasm

TAS

7925449

GO:0005768

endosome

IEA

GO:0005938

cell cortex

IEA

GO:0005886

plasma membrane

TAS

7925449

GO:0045179

apical cortex

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ADAP1	CENTA1 \| GCS1L \| p42IP4	ArfGAP with dual PH domains 1	-	HPRD,BioGRID	12893243
ADCY5	AC5	adenylate cyclase 5	-	HPRD	8206971
AFAP1	AFAP \| AFAP-110 \| FLJ56849	actin filament associated protein 1	-	HPRD	12134071
AKT1	AKT \| MGC99656 \| PKB \| PKB-ALPHA \| PRKBA \| RAC \| RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1	-	HPRD,BioGRID	10085094
AKT3	DKFZp434N0250 \| PKB-GAMMA \| PKBG \| PRKBG \| RAC-PK-gamma \| RAC-gamma \| STK-2	v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)	-	HPRD,BioGRID	12162751
C1QBP	GC1QBP \| HABP1 \| SF2p32 \| gC1Q-R \| gC1qR \| p32	complement component 1, q subcomponent binding protein	-	HPRD,BioGRID	10831594
CDC42	CDC42Hs \| G25K	cell division cycle 42 (GTP binding protein, 25kDa)	-	HPRD	10733591
CSNK2B	CK2B \| CK2N \| CSK2B \| G5A \| MGC138222 \| MGC138224	casein kinase 2, beta polypeptide	-	HPRD,BioGRID	10764587
DAPK3	FLJ36473 \| ZIP \| ZIPK	death-associated protein kinase 3	Reconstituted Complex	BioGRID	12242277
ECT2	FLJ10461 \| MGC138291	epithelial cell transforming sequence 2 oncogene	Affinity Capture-Western	BioGRID	15254234
FADD	GIG3 \| MGC8528 \| MORT1	Fas (TNFRSF6)-associated via death domain	-	HPRD,BioGRID	11739185
FEZ1	-	fasciculation and elongation protein zeta 1 (zygin I)	-	HPRD,BioGRID	9971736
FEZ2	HUM3CL \| MGC117372	fasciculation and elongation protein zeta 2 (zygin II)	-	HPRD,BioGRID	14697253
GRB14	-	growth factor receptor-bound protein 14	-	HPRD,BioGRID	12242277
HABP4	IHABP4 \| Ki-1/57 \| MGC825 \| SERBP1L	hyaluronan binding protein 4	-	HPRD	14699138
HNRNPA1	HNRPA1 \| MGC102835	heterogeneous nuclear ribonucleoprotein A1	PKC-zeta phosphorylates and interacts with hnRNPA1. This interaction was modeled on a demonstrated interaction between PKC-zeta and hnRNPA1, both from unspecified species.	BIND	10383403
IRAK1	IRAK \| pelle	interleukin-1 receptor-associated kinase 1	-	HPRD,BioGRID	11937546
IRS4	IRS-4 \| PY160	insulin receptor substrate 4	-	HPRD	12774026
KRT10	CK10 \| K10 \| KPP	keratin 10	-	HPRD,BioGRID	11585925
MAP2K5	HsT17454 \| MAPKK5 \| MEK5 \| PRKMK5	mitogen-activated protein kinase kinase 5	-	HPRD,BioGRID	11158308
MBP	MGC99675	myelin basic protein	PKC-zeta phosphorylates and interacts with MBP. This interaction was modeled on a demonstrated interaction between PKC-zeta and MBP, both from unspecified species.	BIND	10383403
NCL	C23 \| FLJ45706	nucleolin	-	HPRD,BioGRID	9388266
NFATC2	KIAA0611 \| NFAT1 \| NFATP	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	-	HPRD,BioGRID	12021260
PARD3	ASIP \| Baz \| Bazooka \| FLJ21015 \| PAR3 \| PAR3alpha \| PARD3A \| SE2-5L16 \| SE2-5LT1 \| SE2-5T2	par-3 partitioning defective 3 homolog (C. elegans)	Affinity Capture-Western	BioGRID	12459187
PARD6A	PAR-6A \| PAR6 \| PAR6C \| PAR6alpha \| TAX40 \| TIP-40	par-6 partitioning defective 6 homolog alpha (C. elegans)	-	HPRD,BioGRID	11260256
PARD6G	FLJ45701 \| PAR-6G \| PAR6gamma	par-6 partitioning defective 6 homolog gamma (C. elegans)	-	HPRD,BioGRID	11260256
PAWR	PAR4 \| Par-4	PRKC, apoptosis, WT1, regulator	Par-4 interacts with PKC-zeta. This interaction was modelled on a demonstrated interaction between human Par-4 and rat PKC-zeta.	BIND	8797824
PAWR	PAR4 \| Par-4	PRKC, apoptosis, WT1, regulator	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	8797824
PDLIM7	LMP1	PDZ and LIM domain 7 (enigma)	-	HPRD	8940095
PDPK1	MGC20087 \| MGC35290 \| PDK1 \| PRO0461	3-phosphoinositide dependent protein kinase-1	PRKCZ (PKCZ) interacts with PDPK1 (PDK1). This interaction was modelled on a demonstrated interaction between human PRKCZ and rat PDPK1.	BIND	11781095
			An unspecified isoform of PDPK1 (PDK1) phosphorylates PRKCZ (PKC-zeta). This interaction was modeled on a demonstrated interaction between PDPK1 from an unspecified species and PRKCZ from an unspecified species.	BIND	12223477
			-	HPRD,BioGRID	9748166 \|10764742 \|11781095
PPP1R14A	CPI-17 \| CPI17 \| PPP1INL	protein phosphatase 1, regulatory (inhibitor) subunit 14A	-	HPRD	15003508
PPP3CA	CALN \| CALNA \| CALNA1 \| CCN1 \| CNA1 \| PPP2B	protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform	-	HPRD	12021260
PRKCSH	AGE-R2 \| G19P1 \| PCLD \| PLD1	protein kinase C substrate 80K-H	PRKCZ (PKCZ) interacts with PRKCSH (80K-H).	BIND	15707389
PRKCZ	PKC-ZETA \| PKC2	protein kinase C, zeta	PKC-zeta autophosphorylates.	BIND	15665819
RAF1	CRAF \| NS5 \| Raf-1 \| c-Raf	v-raf-1 murine leukemia viral oncogene homolog 1	-	HPRD,BioGRID	10620507
RELA	MGC131774 \| NFKB3 \| p65	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	-	HPRD,BioGRID	11684013
RPS6KB1	PS6K \| S6K \| S6K1 \| STK14A \| p70(S6K)-alpha \| p70-S6K \| p70-alpha	ribosomal protein S6 kinase, 70kDa, polypeptide 1	Affinity Capture-Western	BioGRID	16931574
SQSTM1	A170 \| OSIL \| PDB3 \| ZIP3 \| p60 \| p62 \| p62B	sequestosome 1	zetaPKC interacts with p62. This interaction was modelled on a demonstrated interaction between rat zetaPKC and human p62.	BIND	12813044
			-	HPRD	9566925 \|10356400
			Affinity Capture-Western	BioGRID	10747026
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	-	HPRD,BioGRID	10527887
TIAM1	FLJ36302	T-cell lymphoma invasion and metastasis 1	Biochemical Activity	BioGRID	10212259
TRAF6	MGC:3310 \| RNF85	TNF receptor-associated factor 6	-	HPRD,BioGRID	10747026
WWC1	FLJ10865 \| FLJ23369 \| KIAA0869 \| KIBRA	WW and C2 domain containing 1	-	HPRD,BioGRID	15081397
YWHAB	GW128 \| HS1 \| KCIP-1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	-	HPRD,BioGRID	10620507
YWHAG	14-3-3GAMMA	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	Affinity Capture-Western	BioGRID	10620507
YWHAH	YWHA1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	Affinity Capture-Western	BioGRID	10620507
YWHAQ	14-3-3 \| 1C5 \| HS1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	Affinity Capture-Western Biochemical Activity Reconstituted Complex	BioGRID	10620507
YWHAZ	KCIP-1 \| MGC111427 \| MGC126532 \| MGC138156	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	Biochemical Activity Reconstituted Complex	BioGRID	10620507 \|12893243

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_CHEMOKINE_SIGNALING_PATHWAY	190	128	All SZGR genes in this pathway
KEGG_ENDOCYTOSIS	183	132	All SZGR genes in this pathway
KEGG_TIGHT_JUNCTION	134	86	All SZGR genes in this pathway
KEGG_INSULIN_SIGNALING_PATHWAY	137	103	All SZGR genes in this pathway
KEGG_TYPE_II_DIABETES_MELLITUS	47	41	All SZGR genes in this pathway
BIOCARTA_PTDINS_PATHWAY	23	16	All SZGR genes in this pathway
PID_RHOA_PATHWAY	45	33	All SZGR genes in this pathway
PID_INSULIN_PATHWAY	45	32	All SZGR genes in this pathway
PID_WNT_NONCANONICAL_PATHWAY	32	26	All SZGR genes in this pathway
PID_MET_PATHWAY	80	60	All SZGR genes in this pathway
PID_CDC42_PATHWAY	70	51	All SZGR genes in this pathway
PID_TXA2PATHWAY	57	43	All SZGR genes in this pathway
PID_IL1_PATHWAY	34	28	All SZGR genes in this pathway
PID_NFAT_3PATHWAY	54	47	All SZGR genes in this pathway
PID_CXCR4_PATHWAY	102	78	All SZGR genes in this pathway
PID_IGF1_PATHWAY	30	23	All SZGR genes in this pathway
PID_TNF_PATHWAY	46	33	All SZGR genes in this pathway
PID_IL2_PI3K_PATHWAY	34	27	All SZGR genes in this pathway
PID_CERAMIDE_PATHWAY	48	37	All SZGR genes in this pathway
PID_P75_NTR_PATHWAY	69	51	All SZGR genes in this pathway
PID_AMB2_NEUTROPHILS_PATHWAY	41	32	All SZGR genes in this pathway
PID_ERBB1_DOWNSTREAM_PATHWAY	105	78	All SZGR genes in this pathway
PID_TRKR_PATHWAY	62	48	All SZGR genes in this pathway
PID_NEPHRIN_NEPH1_PATHWAY	31	24	All SZGR genes in this pathway
PID_INSULIN_GLUCOSE_PATHWAY	26	24	All SZGR genes in this pathway
PID_RAS_PATHWAY	30	22	All SZGR genes in this pathway
REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION	16	7	All SZGR genes in this pathway
REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE	31	25	All SZGR genes in this pathway
REACTOME_HEMOSTASIS	466	331	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX	63	42	All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION	208	138	All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP	1821	933	All SZGR genes in this pathway
CHIN_BREAST_CANCER_COPY_NUMBER_DN	16	10	All SZGR genes in this pathway
CONCANNON_APOPTOSIS_BY_EPOXOMICIN_UP	239	157	All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN	1781	1082	All SZGR genes in this pathway
JOHANSSON_GLIOMAGENESIS_BY_PDGFB_DN	21	16	All SZGR genes in this pathway
LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN	800	473	All SZGR genes in this pathway
SCHEIDEREIT_IKK_INTERACTING_PROTEINS	58	45	All SZGR genes in this pathway
DACOSTA_ERCC3_ALLELE_XPCS_VS_TTD_DN	36	27	All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_DN	464	276	All SZGR genes in this pathway
JECHLINGER_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN	66	47	All SZGR genes in this pathway
GOLDRATH_IMMUNE_MEMORY	65	42	All SZGR genes in this pathway
SANSOM_APC_TARGETS_DN	366	238	All SZGR genes in this pathway
PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_UP	131	87	All SZGR genes in this pathway
LU_AGING_BRAIN_DN	153	120	All SZGR genes in this pathway
BHATI_G2M_ARREST_BY_2METHOXYESTRADIOL_DN	127	75	All SZGR genes in this pathway
CUI_GLUCOSE_DEPRIVATION	60	44	All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP	1305	895	All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K27ME3	79	59	All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3	1069	729	All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K27ME3	341	243	All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3	590	403	All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP	682	433	All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_DN	428	246	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-338	203	209	1A	hsa-miR-338^brain	UCCAGCAUCAGUGAUUUUGUUGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.