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GeneID |
2572
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Symbol |
GAD2
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Synonyms |
GAD65|MGC161605|MGC161607
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Description |
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) |
See related |
HGNC:4093|MIM:138275|Ensembl:ENSG00000136750|HPRD:11817| |
Locus tag |
RP11-420F12.2 |
Gene type |
protein-coding |
Map location |
10p11.23 |
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Gene set name |
Method of gene set |
Evidence |
Info |
Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia] | Click to show detail | GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 5 | | Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0384 | |
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General Gene Expression (microarray) ? |
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Gene Expression in Brain Regions (new) |
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Top co-expressed genes in Brain Regions (new) |
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Gene | Pearson's Correlation | Spearman's Correlation | | |
Top 10 positively co-expressed genes |
CLCN7 | 0.80 | 0.86 | | |
DNAJB12 | 0.80 | 0.83 | | |
ATG2A | 0.78 | 0.83 | | |
RAB36 | 0.78 | 0.76 | | |
RNF123 | 0.77 | 0.83 | | |
ZNF335 | 0.77 | 0.86 | | |
C2orf18 | 0.77 | 0.82 | | |
DPP9 | 0.76 | 0.83 | | |
SPG7 | 0.76 | 0.80 | | |
FLRT1 | 0.76 | 0.84 | | |
Top 10 negatively co-expressed genes | AF347015.21 | -0.62 | -0.62 | | |
AF347015.31 | -0.56 | -0.55 | | |
MT-CO2 | -0.54 | -0.53 | | |
AF347015.8 | -0.53 | -0.52 | | |
MT-CYB | -0.52 | -0.50 | | |
AF347015.27 | -0.52 | -0.53 | | |
C1orf54 | -0.50 | -0.55 | | |
CLEC2B | -0.50 | -0.56 | | |
AF347015.33 | -0.49 | -0.47 | | |
AL139819.3 | -0.49 | -0.55 | | |
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Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
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GO:0004351 | glutamate decarboxylase activity | IEA | glutamate (GO term level: 6) | - |
GO:0005515 | protein binding | IPI | | 10671565 |
GO:0016829 | lyase activity | IEA | | - |
GO:0016831 | carboxy-lyase activity | IEA | | - |
GO:0030170 | pyridoxal phosphate binding | IEA | | - |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
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GO:0007268 | synaptic transmission | TAS | neuron, Synap, Neurotransmitter (GO term level: 6) | 8954991 |
GO:0006540 | glutamate decarboxylation to succinate | TAS | GABA, glutamate, Brain, Neurotransmitter (GO term level: 10) | 1549570 |
GO:0042136 | neurotransmitter biosynthetic process | IEA | neuron, axon, Synap, Neurotransmitter (GO term level: 9) | - |
GO:0019752 | carboxylic acid metabolic process | IEA | | - |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
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GO:0030424 | axon | IEA | neuron, axon, Neurotransmitter (GO term level: 6) | - |
GO:0045202 | synapse | IEA | neuron, Synap, Neurotransmitter, Glial (GO term level: 2) | - |
GO:0000139 | Golgi membrane | IEA | | - |
GO:0005794 | Golgi apparatus | IEA | | - |
GO:0005737 | cytoplasm | IEA | | - |
GO:0005886 | plasma membrane | IEA | | - |
GO:0030054 | cell junction | IEA | | - |
GO:0031410 | cytoplasmic vesicle | IEA | | - |
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- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.
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