Gene Page: EPB41

Summary
GeneID  2035
Symbol  EPB41
Synonyms  4.1R|EL1|HE
Description  erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
See related  HGNC:3377|MIM:130500|Ensembl:ENSG00000159023|HPRD:00558|
Locus tag  RP11-242O24.1
Gene type  protein-coding
Map location  1p33-p32
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 3.9116 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PTBP10.930.82
TGIF20.920.73
SMO0.900.80
TP530.890.73
ITPRIP0.890.74
CHST140.890.79
ERBB20.880.81
TEAD20.880.66
TCF190.880.61
CDK20.880.66
Top 10 negatively co-expressed genes
C5orf53-0.46-0.53
CCNI2-0.41-0.45
CHN1-0.41-0.48
OMG-0.41-0.48
CA11-0.40-0.46
SERPINI1-0.40-0.49
EPHX4-0.40-0.51
CKMT1A-0.40-0.45
ACOT13-0.40-0.50
ACYP2-0.39-0.45
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003779actin bindingIEA-
GO:0005545phosphatidylinositol bindingIDA16669616 
GO:0005488bindingIEA-
GO:0005198structural molecule activityIEA-
GO:0005200structural constituent of cytoskeletonTAS6894932 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008015blood circulationTAS6894932 
GO:0030866cortical actin cytoskeleton organizationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005856cytoskeletonIEA-
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-
GO:0008091spectrinTAS6894932 
GO:0005886plasma membraneTAS9598318 
GO:0019898extrinsic to membraneIEA-
GO:0043234protein complexIDA16060676 
GO:0030863cortical cytoskeletonIDA16254212 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTA1ACTA | ASMA | CFTD | CFTD1 | CFTDM | MPFD | NEM1 | NEM2 | NEM3actin, alpha 1, skeletal muscle-HPRD11071908 
CALRCRT | FLJ26680 | RO | SSA | cC1qRcalreticulinAffinity Capture-MSBioGRID17353931 
CASKCAGH39 | CMG | FLJ22219 | FLJ31914 | LIN2 | MICPCH | TNRC8calcium/calmodulin-dependent serine protein kinase (MAGUK family)-HPRD,BioGRID9660868 
CD44CDW44 | CSPG8 | ECMR-III | HCELL | IN | LHR | MC56 | MDU2 | MDU3 | MGC10468 | MIC4 | MUTCH-I | Pgp1CD44 molecule (Indian blood group)-HPRD12901833 
CDK2p33(CDK2)cyclin-dependent kinase 2Affinity Capture-MSBioGRID17353931 
CENPJBM032 | CPAP | LAP | LIP1 | MCPH6 | MGC131581 | MGC131582 | MGC142222 | MGC142224centromere protein J-HPRD,BioGRID11003675 
DCTN1DAP-150 | DP-150 | HMN7B | P135dynactin 1 (p150, glued homolog, Drosophila)Affinity Capture-WesternBioGRID10189366 
DLG1DKFZp761P0818 | DKFZp781B0426 | DLGH1 | SAP97 | dJ1061C18.1.1 | hdlgdiscs, large homolog 1 (Drosophila)-HPRD,BioGRID7937897 
DRD2D2DR | D2Rdopamine receptor D2-HPRD12181426 
DRD3D3DR | ETM1 | FET1 | MGC149204 | MGC149205dopamine receptor D3-HPRD12181426 
DYNC1H1DHC1 | DHC1a | DKFZp686P2245 | DNCH1 | DNCL | DNECL | DYHC | Dnchc1 | HL-3 | KIAA0325 | p22dynein, cytoplasmic 1, heavy chain 1Affinity Capture-WesternBioGRID10189366 
ECHS1SCEHenoyl Coenzyme A hydratase, short chain, 1, mitochondrialAffinity Capture-MSBioGRID17353931 
EIF3GEIF3-P42 | EIF3S4 | eIF3-delta | eIF3-p44eukaryotic translation initiation factor 3, subunit G-HPRD,BioGRID10887144 
EPB42MGC116735 | MGC116737 | PAerythrocyte membrane protein band 4.2-HPRD2968981 
GYPCCD236 | CD236R | GE | GPC | GYPD | MGC117309 | MGC126191 | MGC126192glycophorin C (Gerbich blood group)-HPRD11423550 
KPNA2IPOA1 | QIP2 | RCH1 | SRP1alphakaryopherin alpha 2 (RAG cohort 1, importin alpha 1)-HPRD,BioGRID10359596 
MYH9DFNA17 | EPSTS | FTNS | MGC104539 | MHA | NMHC-II-A | NMMHCAmyosin, heavy chain 9, non-muscleAffinity Capture-MSBioGRID17353931 
MYL1MLC1F | MLC3Fmyosin, light chain 1, alkali; skeletal, fast-HPRD11071908 
NPPAANF | ANP | ATFB6 | CDD-ANF | PNDnatriuretic peptide precursor AReconstituted ComplexBioGRID12542678 
NUMA1NUMAnuclear mitotic apparatus protein 1-HPRD,BioGRID10189366 
PAICSADE2 | ADE2H1 | AIRC | DKFZp781N1372 | MGC1343 | MGC5024 | PAISphosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetaseAffinity Capture-MSBioGRID17353931 
PFASFGAMS | FGARAT | KIAA0361 | PURLphosphoribosylformylglycinamidine synthaseAffinity Capture-MSBioGRID17353931 
SLC4A1AE1 | BND3 | CD233 | DI | EMPB3 | EPB3 | FR | MGC116750 | MGC116753 | MGC126619 | MGC126623 | RTA1A | SW | WD | WD1 | WRsolute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)-HPRD1639060 
SPTAN1(ALPHA)II-SPECTRIN | FLJ44613 | NEASspectrin, alpha, non-erythrocytic 1 (alpha-fodrin)Reconstituted ComplexBioGRID12044158 
-HPRD12049649 
SPTBHSpTB1spectrin, beta, erythrocytic-HPRD,BioGRID7673158 
SPTBN1ELF | SPTB2 | betaSpIIspectrin, beta, non-erythrocytic 1-HPRD12901833 
TAGLN2HA1756 | KIAA0120transgelin 2Affinity Capture-MSBioGRID17353931 
TJP2MGC26306 | X104 | ZO-2 | ZO2tight junction protein 2 (zona occludens 2)-HPRD,BioGRID10874042 
TPM1C15orf13 | CMD1Y | HTM-alpha | TMSAtropomyosin 1 (alpha)-HPRD11071908 
U2AF1DKFZp313J1712 | FP793 | RN | RNU2AF1 | U2AF35 | U2AFBPU2 small nuclear RNA auxiliary factor 1-HPRD9645944 
VARSG7A | VARS1 | VARS2valyl-tRNA synthetaseAffinity Capture-MSBioGRID17353931 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_TIGHT_JUNCTION 13486All SZGR genes in this pathway
PID_SYNDECAN_2_PATHWAY 3327All SZGR genes in this pathway
BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_UP 206111All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_UP 368234All SZGR genes in this pathway
BOGNI_TREATMENT_RELATED_MYELOID_LEUKEMIA_UP 3019All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LPS_UP 431237All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
CONCANNON_APOPTOSIS_BY_EPOXOMICIN_UP 239157All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_G_UP 238135All SZGR genes in this pathway
LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN 800473All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_5 14789All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
WEI_MIR34A_TARGETS 14897All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_UP 236139All SZGR genes in this pathway
SAKAI_TUMOR_INFILTRATING_MONOCYTES_DN 8151All SZGR genes in this pathway
SU_PANCREAS 5430All SZGR genes in this pathway
MCCLUNG_CREB1_TARGETS_DN 5739All SZGR genes in this pathway
ULE_SPLICING_VIA_NOVA2 4338All SZGR genes in this pathway
MCCLUNG_COCAIN_REWARD_4WK 7547All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_6HR_DN 160101All SZGR genes in this pathway
MARTINEZ_RESPONSE_TO_TRABECTEDIN_DN 271175All SZGR genes in this pathway
ZHENG_BOUND_BY_FOXP3 491310All SZGR genes in this pathway
ZHENG_FOXP3_TARGETS_IN_THYMUS_DN 129All SZGR genes in this pathway
SANSOM_APC_MYC_TARGETS 217138All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_DN 270181All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
LEE_DIFFERENTIATING_T_LYMPHOCYTE 200115All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP 395249All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
VALK_AML_CLUSTER_7 2816All SZGR genes in this pathway
YAGI_AML_WITH_T_8_21_TRANSLOCATION 368247All SZGR genes in this pathway
CHANDRAN_METASTASIS_UP 221135All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_11 10368All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_PRONEURAL 177132All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
WIERENGA_STAT5A_TARGETS_UP 217131All SZGR genes in this pathway
MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_UP 259159All SZGR genes in this pathway
STEINER_ERYTHROCYTE_MEMBRANE_GENES 1510All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_DN 428246All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1287037091Ahsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-144701707m8hsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-205299129981A,m8hsa-miR-205UCCUUCAUUCCACCGGAGUCUG
miR-277037101A,m8hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-30-5p304230491A,m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-3319449501Ahsa-miR-331brainGCCCCUGGGCCUAUCCUAGAA
miR-377249525021A,m8hsa-miR-377AUCACACAAAGGCAACUUUUGU
miR-38131903196m8hsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-504256025671A,m8hsa-miR-504AGACCCUGGUCUGCACUCUAU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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