Gene Page: DFFA

Summary
GeneID  1676
Symbol  DFFA
Synonyms  DFF-45|DFF1|ICAD
Description  DNA fragmentation factor, 45kDa, alpha polypeptide
See related  HGNC:2772|MIM:601882|Ensembl:ENSG00000160049|HPRD:03531|
Locus tag  -
Gene type  protein-coding
Map location  1p36.3-p36.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0069 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004537caspase-activated deoxyribonuclease activityTAS9108473 
GO:0042802identical protein bindingIPI17353931 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006309DNA fragmentation during apoptosisIDA15572351 
GO:0007242intracellular signaling cascadeTAS9108473 
GO:0006917induction of apoptosisIEA-
GO:0043066negative regulation of apoptosisIDA9564035 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolTAS9108473 
GO:0005622intracellularIEA-
GO:0005634nucleusIDA15572351 
GO:0005654nucleoplasmEXP9108473 
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BAK1BAK | BAK-LIKE | BCL2L7 | CDN1 | MGC117255 | MGC3887BCL2-antagonist/killer 1Affinity Capture-MSBioGRID17353931 
CASP3CPP32 | CPP32B | SCA-1caspase 3, apoptosis-related cysteine peptidase-HPRD11752060 
CIDEB-cell death-inducing DFFA-like effector b-HPRD,BioGRID10619428 
DFFBCAD | CPAN | DFF-40 | DFF2 | DFF40DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)-HPRD9422506 |10409614 
|10527860 |10527861 
|10932250 |11371636 
Affinity Capture-MS
Affinity Capture-Western		BioGRID10527860 |17353931 
EWSR1EWSEwing sarcoma breakpoint region 1Two-hybridBioGRID16189514 
HERC1p532 | p619hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1Affinity Capture-MSBioGRID17353931 
MCCDKFZp762O1615 | FLJ38893 | FLJ46755 | MCC1mutated in colorectal cancersAffinity Capture-MSBioGRID17353931 
NAP1L5DRLMnucleosome assembly protein 1-like 5Affinity Capture-MSBioGRID17353931 
NECAB2EFCBP2N-terminal EF-hand calcium binding protein 2Two-hybridBioGRID16189514 
TMBIM4CGI-119 | GAAP | S1R | ZPROtransmembrane BAX inhibitor motif containing 4Affinity Capture-MSBioGRID17353931 
USP15KIAA0529 | MGC131982 | MGC149838 | MGC74854 | UNPH4ubiquitin specific peptidase 15Affinity Capture-MSBioGRID17353931 
YWHAG14-3-3GAMMAtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide-HPRD15324660 
YWHAZKCIP-1 | MGC111427 | MGC126532 | MGC138156tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptideAffinity Capture-MSBioGRID17353931 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_APOPTOSIS 8862All SZGR genes in this pathway
BIOCARTA_DNAFRAGMENT_PATHWAY 106All SZGR genes in this pathway
BIOCARTA_CASPASE_PATHWAY 2315All SZGR genes in this pathway
BIOCARTA_FAS_PATHWAY 3022All SZGR genes in this pathway
BIOCARTA_SET_PATHWAY 116All SZGR genes in this pathway
BIOCARTA_HIVNEF_PATHWAY 5843All SZGR genes in this pathway
BIOCARTA_DEATH_PATHWAY 3324All SZGR genes in this pathway
BIOCARTA_MITOCHONDRIA_PATHWAY 2115All SZGR genes in this pathway
BIOCARTA_TNFR1_PATHWAY 2921All SZGR genes in this pathway
SA_CASPASE_CASCADE 1913All SZGR genes in this pathway
ST_FAS_SIGNALING_PATHWAY 6554All SZGR genes in this pathway
PID_HIV_NEF_PATHWAY 3526All SZGR genes in this pathway
PID_CASPASE_PATHWAY 5239All SZGR genes in this pathway
REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION 1310All SZGR genes in this pathway
REACTOME_APOPTOSIS 14894All SZGR genes in this pathway
REACTOME_APOPTOTIC_EXECUTION_PHASE 5437All SZGR genes in this pathway
LIU_SOX4_TARGETS_DN 309191All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN 526357All SZGR genes in this pathway
DITTMER_PTHLH_TARGETS_DN 7351All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_DN 536332All SZGR genes in this pathway
MARKS_HDAC_TARGETS_UP 2315All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
DAIRKEE_TERT_TARGETS_DN 12479All SZGR genes in this pathway
WATTEL_AUTONOMOUS_THYROID_ADENOMA_DN 5529All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
ASTON_MAJOR_DEPRESSIVE_DISORDER_DN 160110All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_SUBGROUPS 3020All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_6HR_DN 160101All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_4 307185All SZGR genes in this pathway
STEIN_ESRRA_TARGETS_UP 388234All SZGR genes in this pathway
FUJII_YBX1_TARGETS_DN 202132All SZGR genes in this pathway
MOOTHA_PGC 420269All SZGR genes in this pathway
STEIN_ESRRA_TARGETS 535325All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
KYNG_RESPONSE_TO_H2O2_VIA_ERCC6_DN 4631All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_1HR_DN 222147All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B 549316All SZGR genes in this pathway


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.