Gene Page: SHC1

Summary
GeneID  6464
Symbol  SHC1
Synonyms  FLJ26504|SHC|SHCA
Description  SHC (Src homology 2 domain containing) transforming protein 1
See related  HGNC:10840|MIM:600560|Ensembl:ENSG00000160691|HPRD:02780|
Locus tag  RP11-307C12.1
Gene type  protein-coding
Map location  1q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0235 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00814 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.4558 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
COPS40.910.89
ATP5F10.880.87
PSMA10.870.83
CHMP50.870.86
C20orf70.860.82
EBNA1BP20.860.79
TBPL10.860.84
ORC5L0.860.82
ACTR100.860.80
TMEM490.850.83
Top 10 negatively co-expressed genes
AF347015.26-0.65-0.50
AF347015.2-0.64-0.46
AF347015.18-0.64-0.51
MT-CYB-0.58-0.43
AF347015.8-0.58-0.42
AF347015.15-0.58-0.43
MT-CO2-0.57-0.39
AC016705.1-0.55-0.53
GPT-0.55-0.55
FGFRL1-0.54-0.49
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005159insulin-like growth factor receptor bindingIPI7541045 
GO:0005158insulin receptor bindingIPI7537849 |7559478 
GO:0005543phospholipid bindingTAS14676841 
GO:0005068transmembrane receptor protein tyrosine kinase adaptor protein activityTAS14676841 
GO:0005515protein bindingIPI8491186 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000187activation of MAPK activityIDA14676841 
GO:0000187activation of MAPK activityISS-
GO:0001558regulation of cell growthIEA-
GO:0007176regulation of epidermal growth factor receptor activityTAS1623525 
GO:0007173epidermal growth factor receptor signaling pathwayTAS1623525 
GO:0007265Ras protein signal transductionEXP11520933 
GO:0007242intracellular signaling cascadeIEA-
GO:0008284positive regulation of cell proliferationNAS14676841 
GO:0045840positive regulation of mitosisNAS14676841 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP7739560 |8493579 |8810325 
|9544989 |9690470 
|14665640 
GO:0005737cytoplasmIEA-
GO:0005739mitochondrionIEA-
GO:0005886plasma membraneIDA14676841 
GO:0005886plasma membraneISS-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinaseAffinity Capture-WesternBioGRID8112292 |10194451 
ALKCD246 | Ki-1 | TFG/ALKanaplastic lymphoma receptor tyrosine kinaseAffinity Capture-WesternBioGRID11888936 
-HPRD9174053 
AP2A1ADTAA | AP2-ALPHA | CLAPA1adaptor-related protein complex 2, alpha 1 subunit-HPRD8617812 |11302736 
AP2A2ADTAB | CLAPA2 | HIP9 | HYPJadaptor-related protein complex 2, alpha 2 subunit-HPRD,BioGRID8617812 
APPAAA | ABETA | ABPP | AD1 | APPI | CTFgamma | CVAP | PN2amyloid beta (A4) precursor protein-HPRD,BioGRID9045663 |11877420 
AXLJTK11 | UFOAXL receptor tyrosine kinaseShcA interacts with Axl.BIND8610109 
BCL3BCL4 | D19S37B-cell CLL/lymphoma 3-HPRD11707390 
BCRALL | BCR-ABL1 | BCR1 | CML | D22S11 | D22S662 | FLJ16453 | PHLbreakpoint cluster region-HPRD,BioGRID9209414 
CALCOCO2MGC17318 | NDP52calcium binding and coiled-coil domain 2Two-hybridBioGRID16189514 
CALD1CDM | H-CAD | L-CAD | MGC21352 | NAG22caldesmon 1-HPRD,BioGRID10559276 
CBLC-CBL | CBL2 | RNF55Cas-Br-M (murine) ecotropic retroviral transforming sequence-HPRD,BioGRID10570290 
CBLBDKFZp686J10223 | DKFZp779A0729 | DKFZp779F1443 | FLJ36865 | FLJ41152 | Nbla00127 | RNF56Cas-Br-M (murine) ecotropic retroviral transforming sequence b-HPRD,BioGRID9614102 
CD22FLJ22814 | MGC130020 | SIGLEC-2 | SIGLEC2CD22 molecule-HPRD,BioGRID10748054 
CD247CD3-ZETA | CD3H | CD3Q | CD3Z | T3Z | TCRZCD247 molecule-HPRD8656061 
CD3EFLJ18683 | T3E | TCRECD3e molecule, epsilon (CD3-TCR complex)-HPRD11855827 
CDH57B4 | CD144 | FLJ17376cadherin 5, type 2 (vascular endothelium)-HPRD,BioGRID11950700 
CEACAM1BGP | BGP1 | BGPIcarcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)-HPRD,BioGRID11694516 
CRKL-v-crk sarcoma virus CT10 oncogene homolog (avian)-like-HPRD,BioGRID9344843 
CSF2RBCD131 | CDw131 | IL3RB | IL5RBcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)-HPRD,BioGRID10477722 |10704825 
CSF3RCD114 | GCSFRcolony stimulating factor 3 receptor (granulocyte)-HPRD,BioGRID9824671 
CSKMGC117393c-src tyrosine kinase-HPRD,BioGRID10037694 |12048194 
DAG1156DAG | A3a | AGRNR | DAGdystroglycan 1 (dystrophin-associated glycoprotein 1)-HPRD,BioGRID11724572 
DDR1CAK | CD167 | DDR | EDDR1 | MCK10 | NEP | NTRK4 | PTK3 | PTK3A | RTK6 | TRKEdiscoidin domain receptor tyrosine kinase 1-HPRD10783152 
DDR1 interacts with Shc.BIND9659899 |10681566 
DDR2MIG20a | NTRKR3 | TKT | TYRO10discoidin domain receptor tyrosine kinase 2-HPRD,BioGRID11884411 
DOK1MGC117395 | MGC138860 | P62DOKdocking protein 1, 62kDa (downstream of tyrosine kinase 1)Affinity Capture-WesternBioGRID10822173 
DOK2p56DOK | p56dok-2docking protein 2, 56kDaAffinity Capture-WesternBioGRID10822173 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)Shc interacts with activated EGFR.BIND1623525 
ShcA interacts with EGFR.BIND8610109 
ShcA interacts with the EGFR.BIND8577769 |8610109 
|8943228 
-HPRD,BioGRID9544989 
EGF-R interacts with Shc. This interaction was modelled on a demonstrated interaction between human EGF-R and mouse Shc.BIND8887653 
EPHA2ECKEPH receptor A2-HPRD,BioGRID12400011 
EPORMGC138358erythropoietin receptor-HPRD,BioGRID8400282 
EPS8-epidermal growth factor receptor pathway substrate 8-HPRD,BioGRID7791787 
ERBB2CD340 | HER-2 | HER-2/neu | HER2 | NEU | NGL | TKR1v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)-HPRD,BioGRID9710588 
ERBB3ErbB-3 | HER3 | LCCS2 | MDA-BF-1 | MGC88033 | c-erbB-3 | c-erbB3 | erbB3-S | p180-ErbB3 | p45-sErbB3 | p85-sErbB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)-HPRD9694850 
Affinity Capture-MSBioGRID16729043 
ERBB4HER4 | MGC138404 | p180erbB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)Affinity Capture-MSBioGRID16729043 
ESR1DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1estrogen receptor 1-HPRD,BioGRID11773443 
FCGR2ACD32 | CD32A | CDw32 | FCG2 | FCGR2 | FCGR2A1 | FcGR | IGFR2 | MGC23887 | MGC30032Fc fragment of IgG, low affinity IIa, receptor (CD32)-HPRD,BioGRID8940017 |10382761 
FCGR3ACD16 | CD16A | FCG3 | FCGR3 | FCGRIII | FCR-10 | FCRIII | FCRIIIA | IGFR3Fc fragment of IgG, low affinity IIIa, receptor (CD16a)-HPRD9378963 
FGFR1BFGFR | CD331 | CEK | FGFBR | FLG | FLJ99988 | FLT2 | HBGFR | KAL2 | N-SAMfibroblast growth factor receptor 1-HPRD7514169 
FLT1FLT | VEGFR1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)-HPRD,BioGRID10749680 
FLT3CD135 | FLK2 | STK1fms-related tyrosine kinase 3-HPRD11027663 
FLT4FLT41 | LMPH1A | PCL | VEGFR3fms-related tyrosine kinase 4-HPRD7675451 |8662748 
|9927207 
Affinity Capture-Western
Reconstituted Complex
BioGRID7970715 |8662748 
|9927207 
GAB2KIAA0571GRB2-associated binding protein 2Affinity Capture-WesternBioGRID11782427 |12135708 
GH1GH | GH-N | GHN | hGH-Ngrowth hormone 1Biochemical ActivityBioGRID7535773 
GHRGHBPgrowth hormone receptor-HPRD9632636 
Reconstituted ComplexBioGRID7535773 
GRAP2GADS | GRAP-2 | GRB2L | GRBLG | GRID | GRPL | GrbX | Grf40 | Mona | P38GRB2-related adaptor protein 2-HPRD9872323 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2Affinity Capture-MS
Affinity Capture-Western
Co-fractionation
Reconstituted Complex
BioGRID7514169 |7524086 
|7535773 |8112292 
|8195171 |8294403 
|8491186 |8647288 
|8662733 |9045692 
|9083103 |9927207 
|10080542 |10477741 
|10570290 |11302736 
|11505033 |11964172 
|12441060 |12577067 
Shc interacts with Grb2. This interaction was modelled on a demonstrated interaction between Shc from human and Grb2 from rat and an unspecified species.BIND8084588 
-HPRD7524086 |7535773 
|8491186 |11707405 
An unspecified isoform of Grb2 interacts with the p52 isoform of Shc.BIND9148935 
Grb2 interacts with Shc.BIND7515480 |8112292 
|8939605 |10891441 
IGF1RCD221 | IGFIR | JTK13 | MGC142170 | MGC142172 | MGC18216insulin-like growth factor 1 receptorIGFIR interacts with SHC.BIND7541045 
-HPRD,BioGRID8776723 
IL2IL-2 | TCGF | lymphokineinterleukin 2-HPRD10662798 
IL2RBCD122 | P70-75interleukin 2 receptor, beta-HPRD,BioGRID8294403 |10602027 
IL2RGCD132 | IMD4 | SCIDX | SCIDX1interleukin 2 receptor, gamma (severe combined immunodeficiency)-HPRD,BioGRID8643566 
IL4RCD124 | IL4RAinterleukin 4 receptor-HPRD,BioGRID10652211 |11714803 
INPP5DMGC104855 | MGC142140 | MGC142142 | SHIP | SHIP1 | SIP-145 | hp51CNinositol polyphosphate-5-phosphatase, 145kDa-HPRD8643691 |8723348 
|8874179 
Affinity Capture-WesternBioGRID8643691 |10194451 
|10822173 |10900203 
|12024011 
SHC interacts with SHIP1BIND10822173 
INPPL1SHIP2inositol polyphosphate phosphatase-like 1-HPRD,BioGRID9660833 
INSRCD220 | HHF5insulin receptor-HPRD9083103 
Tyrosine-phosphorylated IR interacts with Shc. This interaction was modeled on a demonstrated interaction between human IR and Shc from an unspecified species.BIND10340378 
IRS1HIRS-1insulin receptor substrate 1Direct interaction between IRS-1 and SHC. This interaction was modeled on a demonstrated interaction between rat IRS-1 and human SHCBIND9202037 
-HPRD,BioGRID7499194 
IRS2-insulin receptor substrate 2-HPRD11505033 
ITGB3CD61 | GP3A | GPIIIaintegrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)Integrin-beta-3 interacts with Shc.BIND10964917 
ITGB4CD104integrin, beta 4-HPRD,BioGRID11044453 
JAK2JTK10Janus kinase 2 (a protein tyrosine kinase)-HPRD,BioGRID7535773 |9126968 
KDRCD309 | FLK1 | VEGFR | VEGFR2kinase insert domain receptor (a type III receptor tyrosine kinase)Affinity Capture-WesternBioGRID10319320 |11950700 
-HPRD10749680 
LRP1A2MR | APOER | APR | CD91 | FLJ16451 | IGFBP3R | LRP | MGC88725 | TGFBR5low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)Affinity Capture-Western
Reconstituted Complex
BioGRID11854294 |12789267 
-HPRD12069755 |12789267 
LTKTYK1leukocyte receptor tyrosine kinase-HPRD,BioGRID9223670 
LYNFLJ26625 | JTK8v-yes-1 Yamaguchi sarcoma viral related oncogene homolog-HPRD,BioGRID7650013 
MAP4K1HPK1mitogen-activated protein kinase kinase kinase kinase 1-HPRD9346925 
MAPK1ERK | ERK2 | ERT1 | MAPK2 | P42MAPK | PRKM1 | PRKM2 | p38 | p40 | p41 | p41mapkmitogen-activated protein kinase 1-HPRD,BioGRID10996427 
MAPKAPK2MK2mitogen-activated protein kinase-activated protein kinase 2-HPRD,BioGRID15094067 
METAUTS9 | HGFR | RCCP2 | c-Metmet proto-oncogene (hepatocyte growth factor receptor)-HPRD7731718 
Affinity Capture-WesternBioGRID9660480 
MMECALLA | CD10 | DKFZp686O16152 | MGC126681 | MGC126707 | NEPmembrane metallo-endopeptidase-HPRD,BioGRID9659899 
MST1RCD136 | CDw136 | PTK8 | RONmacrophage stimulating 1 receptor (c-met-related tyrosine kinase)-HPRD,BioGRID8918464 
NGFRCD271 | Gp80-LNGFR | TNFRSF16 | p75(NTR) | p75NTRnerve growth factor receptor (TNFR superfamily, member 16)-HPRD,BioGRID7541035 
NTRK1DKFZp781I14186 | MTC | TRK | TRK1 | TRKA | p140-TrkAneurotrophic tyrosine kinase, receptor, type 1Shc interacts with Trk. This interaction was modelled on a demonstrated interaction between SHC from rat or mouse and Trk from human.BIND8155326 
Shc interacts with NGFR.BIND8577769 
ShcA interacts with TrkA.BIND7542991 |8610109 
|8943228 
Affinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID8183561 |9856458 
|10092678 |10708759 
|12446789 
NTRK2GP145-TrkB | TRKBneurotrophic tyrosine kinase, receptor, type 2Reconstituted ComplexBioGRID10092678 
NTRK3TRKC | gp145(trkC)neurotrophic tyrosine kinase, receptor, type 3-HPRD7657612 
Reconstituted ComplexBioGRID10092678 
PAG1CBP | FLJ37858 | MGC138364 | PAGphosphoprotein associated with glycosphingolipid microdomains 1-HPRD,BioGRID10790433 
PDGFRBCD140B | JTK12 | PDGF-R-beta | PDGFR | PDGFR1platelet-derived growth factor receptor, beta polypeptidePDGFR interacts with p52ShcBIND8195171 
PDGFR interacts with p66Shc.BIND8195171 
-HPRD,BioGRID8195171 
Autophosphorylated PDGFR interacts with SHC. This interaction was modelled on a demonstrated interaction between human PDGFR and SHC from an unspecified species.BIND8890167 
PIK3C2BC2-PI3K | DKFZp686G16234phosphoinositide-3-kinase, class 2, beta polypeptideReconstituted ComplexBioGRID11533253 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)Reconstituted ComplexBioGRID7537361 
p85 interacts with Shc.BIND8662998 
-HPRD8662998 
PIK3R2P85B | p85 | p85-BETAphosphoinositide-3-kinase, regulatory subunit 2 (beta)-HPRD8662998 
PLCG1PLC-II | PLC1 | PLC148 | PLCgamma1phospholipase C, gamma 1Affinity Capture-WesternBioGRID8662733 
PLCG2-phospholipase C, gamma 2 (phosphatidylinositol-specific)-HPRD,BioGRID10623845 
PLSCR1MMTRA1Bphospholipid scramblase 1Affinity Capture-Western
Reconstituted Complex
BioGRID12009895 |12871937 
PPP2R5AB56A | MGC131915 | PR61Aprotein phosphatase 2, regulatory subunit B', alpha isoform-HPRD11884620 
PRKCDMAY1 | MGC49908 | PKCD | nPKC-deltaprotein kinase C, delta-HPRD,BioGRID12024011 
PTK2FADK | FAK | FAK1 | pp125FAKPTK2 protein tyrosine kinase 2-HPRD,BioGRID11980671 
Shc interacts with FAK. This interaction was modeled on a demonstrated interaction between human Shc and mouse FAK.BIND9148935 
PTK2BCADTK | CAKB | FADK2 | FAK2 | FRNK | PKB | PTK | PYK2 | RAFTKPTK2B protein tyrosine kinase 2 beta-HPRD7544443 
PTPN11BPTP3 | CFC | MGC14433 | NS1 | PTP-1D | PTP2C | SH-PTP2 | SH-PTP3 | SHP2protein tyrosine phosphatase, non-receptor type 11-HPRD10650943 
PTPN12PTP-PEST | PTPG1protein tyrosine phosphatase, non-receptor type 12-HPRD,BioGRID7929214 |8626541 
|11432829 
RAPGEF1C3G | DKFZp781P1719 | GRF2Rap guanine nucleotide exchange factor (GEF) 1-HPRD,BioGRID9344843 
RETCDHF12 | HSCR1 | MEN2A | MEN2B | MTC1 | PTC | RET-ELE1 | RET51ret proto-oncogeneRET9 phosphorylates Shc.BIND9047383 
-HPRD,BioGRID8183561 |9047384 
SHCBP1FLJ22009 | MGC26900 | PALSHC SH2-domain binding protein 1-HPRD,BioGRID10086341 
SOS1GF1 | GGF1 | GINGF | HGF | NS4son of sevenless homolog 1 (Drosophila)Affinity Capture-WesternBioGRID9344843 |10570290 
|10675333 |10783152 
SOS2FLJ25596son of sevenless homolog 2 (Drosophila)Affinity Capture-WesternBioGRID10675333 
SP1-Sp1 transcription factor-HPRD7933095 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)Src interacts with Shc. This interaction was modelled on demonstrated interactions between human Src and rat Shc, and between Src from unspecified species and human Shc.BIND7515480 |8939605 
STAT5AMGF | STAT5signal transducer and activator of transcription 5AAffinity Capture-WesternBioGRID10996427 
STAT5BSTAT5signal transducer and activator of transcription 5BAffinity Capture-WesternBioGRID10996427 
TPR-translocated promoter region (to activated MET oncogene)-HPRD11896612 
VAV3FLJ40431vav 3 guanine nucleotide exchange factor-HPRD,BioGRID11094073 
ZAP70FLJ17670 | FLJ17679 | SRK | STD | TZK | ZAP-70zeta-chain (TCR) associated protein kinase 70kDa-HPRD,BioGRID8761298 |9685404 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-103793851Ahsa-miR-10aUACCCUGUAGAUCCGAAUUUGUG
hsa-miR-10bUACCCUGUAGAACCGAAUUUGU
miR-124/506430436m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-139100310091Ahsa-miR-139brainUCUACAGUGCACGUGUCU
miR-200bc/4292142201Ahsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-203.17287351A,m8hsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-204/211146814751A,m8hsa-miR-204brainUUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211UUCCCUUUGUCAUCCUUCGCCU
miR-219931937m8hsa-miR-219brainUGAUUGUCCAAACGCAAUUCU
miR-9209215m8hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
miR-96255261m8hsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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