ABL1 | ABL | JTK7 | bcr/abl | c-ABL | p150 | v-abl | c-abl oncogene 1, receptor tyrosine kinase | Affinity Capture-Western | BioGRID | 8112292 |10194451
|
ALK | CD246 | Ki-1 | TFG/ALK | anaplastic lymphoma receptor tyrosine kinase | Affinity Capture-Western | BioGRID | 11888936 |
- | HPRD | 9174053 |
AP2A1 | ADTAA | AP2-ALPHA | CLAPA1 | adaptor-related protein complex 2, alpha 1 subunit | - | HPRD | 8617812 |11302736
|
AP2A2 | ADTAB | CLAPA2 | HIP9 | HYPJ | adaptor-related protein complex 2, alpha 2 subunit | - | HPRD,BioGRID | 8617812 |
APP | AAA | ABETA | ABPP | AD1 | APPI | CTFgamma | CVAP | PN2 | amyloid beta (A4) precursor protein | - | HPRD,BioGRID | 9045663 |11877420
|
AXL | JTK11 | UFO | AXL receptor tyrosine kinase | ShcA interacts with Axl. | BIND | 8610109 |
BCL3 | BCL4 | D19S37 | B-cell CLL/lymphoma 3 | - | HPRD | 11707390 |
BCR | ALL | BCR-ABL1 | BCR1 | CML | D22S11 | D22S662 | FLJ16453 | PHL | breakpoint cluster region | - | HPRD,BioGRID | 9209414 |
CALCOCO2 | MGC17318 | NDP52 | calcium binding and coiled-coil domain 2 | Two-hybrid | BioGRID | 16189514 |
CALD1 | CDM | H-CAD | L-CAD | MGC21352 | NAG22 | caldesmon 1 | - | HPRD,BioGRID | 10559276 |
CBL | C-CBL | CBL2 | RNF55 | Cas-Br-M (murine) ecotropic retroviral transforming sequence | - | HPRD,BioGRID | 10570290 |
CBLB | DKFZp686J10223 | DKFZp779A0729 | DKFZp779F1443 | FLJ36865 | FLJ41152 | Nbla00127 | RNF56 | Cas-Br-M (murine) ecotropic retroviral transforming sequence b | - | HPRD,BioGRID | 9614102 |
CD22 | FLJ22814 | MGC130020 | SIGLEC-2 | SIGLEC2 | CD22 molecule | - | HPRD,BioGRID | 10748054 |
CD247 | CD3-ZETA | CD3H | CD3Q | CD3Z | T3Z | TCRZ | CD247 molecule | - | HPRD | 8656061 |
CD3E | FLJ18683 | T3E | TCRE | CD3e molecule, epsilon (CD3-TCR complex) | - | HPRD | 11855827 |
CDH5 | 7B4 | CD144 | FLJ17376 | cadherin 5, type 2 (vascular endothelium) | - | HPRD,BioGRID | 11950700 |
CEACAM1 | BGP | BGP1 | BGPI | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | - | HPRD,BioGRID | 11694516 |
CRKL | - | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | - | HPRD,BioGRID | 9344843 |
CSF2RB | CD131 | CDw131 | IL3RB | IL5RB | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | - | HPRD,BioGRID | 10477722 |10704825
|
CSF3R | CD114 | GCSFR | colony stimulating factor 3 receptor (granulocyte) | - | HPRD,BioGRID | 9824671 |
CSK | MGC117393 | c-src tyrosine kinase | - | HPRD,BioGRID | 10037694 |12048194
|
DAG1 | 156DAG | A3a | AGRNR | DAG | dystroglycan 1 (dystrophin-associated glycoprotein 1) | - | HPRD,BioGRID | 11724572 |
DDR1 | CAK | CD167 | DDR | EDDR1 | MCK10 | NEP | NTRK4 | PTK3 | PTK3A | RTK6 | TRKE | discoidin domain receptor tyrosine kinase 1 | - | HPRD | 10783152 |
DDR1 interacts with Shc. | BIND | 9659899 |10681566
|
DDR2 | MIG20a | NTRKR3 | TKT | TYRO10 | discoidin domain receptor tyrosine kinase 2 | - | HPRD,BioGRID | 11884411 |
DOK1 | MGC117395 | MGC138860 | P62DOK | docking protein 1, 62kDa (downstream of tyrosine kinase 1) | Affinity Capture-Western | BioGRID | 10822173 |
DOK2 | p56DOK | p56dok-2 | docking protein 2, 56kDa | Affinity Capture-Western | BioGRID | 10822173 |
EGFR | ERBB | ERBB1 | HER1 | PIG61 | mENA | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | Shc interacts with activated EGFR. | BIND | 1623525 |
ShcA interacts with EGFR. | BIND | 8610109 |
ShcA interacts with the EGFR. | BIND | 8577769 |8610109 |8943228 |
- | HPRD,BioGRID | 9544989 |
EGF-R interacts with Shc. This interaction was modelled on a demonstrated interaction between human EGF-R and mouse Shc. | BIND | 8887653 |
EPHA2 | ECK | EPH receptor A2 | - | HPRD,BioGRID | 12400011 |
EPOR | MGC138358 | erythropoietin receptor | - | HPRD,BioGRID | 8400282 |
EPS8 | - | epidermal growth factor receptor pathway substrate 8 | - | HPRD,BioGRID | 7791787 |
ERBB2 | CD340 | HER-2 | HER-2/neu | HER2 | NEU | NGL | TKR1 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | - | HPRD,BioGRID | 9710588 |
ERBB3 | ErbB-3 | HER3 | LCCS2 | MDA-BF-1 | MGC88033 | c-erbB-3 | c-erbB3 | erbB3-S | p180-ErbB3 | p45-sErbB3 | p85-sErbB3 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | - | HPRD | 9694850 |
Affinity Capture-MS | BioGRID | 16729043 |
ERBB4 | HER4 | MGC138404 | p180erbB4 | v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) | Affinity Capture-MS | BioGRID | 16729043 |
ESR1 | DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1 | estrogen receptor 1 | - | HPRD,BioGRID | 11773443 |
FCGR2A | CD32 | CD32A | CDw32 | FCG2 | FCGR2 | FCGR2A1 | FcGR | IGFR2 | MGC23887 | MGC30032 | Fc fragment of IgG, low affinity IIa, receptor (CD32) | - | HPRD,BioGRID | 8940017 |10382761
|
FCGR3A | CD16 | CD16A | FCG3 | FCGR3 | FCGRIII | FCR-10 | FCRIII | FCRIIIA | IGFR3 | Fc fragment of IgG, low affinity IIIa, receptor (CD16a) | - | HPRD | 9378963 |
FGFR1 | BFGFR | CD331 | CEK | FGFBR | FLG | FLJ99988 | FLT2 | HBGFR | KAL2 | N-SAM | fibroblast growth factor receptor 1 | - | HPRD | 7514169 |
FLT1 | FLT | VEGFR1 | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | - | HPRD,BioGRID | 10749680 |
FLT3 | CD135 | FLK2 | STK1 | fms-related tyrosine kinase 3 | - | HPRD | 11027663 |
FLT4 | FLT41 | LMPH1A | PCL | VEGFR3 | fms-related tyrosine kinase 4 | - | HPRD | 7675451 |8662748 |9927207 |
Affinity Capture-Western Reconstituted Complex | BioGRID | 7970715 |8662748 |9927207 |
GAB2 | KIAA0571 | GRB2-associated binding protein 2 | Affinity Capture-Western | BioGRID | 11782427 |12135708
|
GH1 | GH | GH-N | GHN | hGH-N | growth hormone 1 | Biochemical Activity | BioGRID | 7535773 |
GHR | GHBP | growth hormone receptor | - | HPRD | 9632636 |
Reconstituted Complex | BioGRID | 7535773 |
GRAP2 | GADS | GRAP-2 | GRB2L | GRBLG | GRID | GRPL | GrbX | Grf40 | Mona | P38 | GRB2-related adaptor protein 2 | - | HPRD | 9872323 |
GRB2 | ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084 | growth factor receptor-bound protein 2 | Affinity Capture-MS Affinity Capture-Western Co-fractionation Reconstituted Complex | BioGRID | 7514169 |7524086 |7535773 |8112292 |8195171 |8294403 |8491186 |8647288 |8662733 |9045692 |9083103 |9927207 |10080542 |10477741 |10570290 |11302736 |11505033 |11964172 |12441060 |12577067
|
Shc interacts with Grb2. This interaction was modelled on a demonstrated interaction between Shc from human and Grb2 from rat and an unspecified species. | BIND | 8084588 |
- | HPRD | 7524086 |7535773 |8491186 |11707405
|
An unspecified isoform of Grb2 interacts with the p52 isoform of Shc. | BIND | 9148935 |
Grb2 interacts with Shc. | BIND | 7515480 |8112292 |8939605 |10891441
|
IGF1R | CD221 | IGFIR | JTK13 | MGC142170 | MGC142172 | MGC18216 | insulin-like growth factor 1 receptor | IGFIR interacts with SHC. | BIND | 7541045 |
- | HPRD,BioGRID | 8776723 |
IL2 | IL-2 | TCGF | lymphokine | interleukin 2 | - | HPRD | 10662798 |
IL2RB | CD122 | P70-75 | interleukin 2 receptor, beta | - | HPRD,BioGRID | 8294403 |10602027
|
IL2RG | CD132 | IMD4 | SCIDX | SCIDX1 | interleukin 2 receptor, gamma (severe combined immunodeficiency) | - | HPRD,BioGRID | 8643566 |
IL4R | CD124 | IL4RA | interleukin 4 receptor | - | HPRD,BioGRID | 10652211 |11714803
|
INPP5D | MGC104855 | MGC142140 | MGC142142 | SHIP | SHIP1 | SIP-145 | hp51CN | inositol polyphosphate-5-phosphatase, 145kDa | - | HPRD | 8643691 |8723348 |8874179 |
Affinity Capture-Western | BioGRID | 8643691 |10194451 |10822173 |10900203 |12024011 |
SHC interacts with SHIP1 | BIND | 10822173 |
INPPL1 | SHIP2 | inositol polyphosphate phosphatase-like 1 | - | HPRD,BioGRID | 9660833 |
INSR | CD220 | HHF5 | insulin receptor | - | HPRD | 9083103 |
Tyrosine-phosphorylated IR interacts with Shc. This interaction was modeled on a demonstrated interaction between human IR and Shc from an unspecified species. | BIND | 10340378 |
IRS1 | HIRS-1 | insulin receptor substrate 1 | Direct interaction between IRS-1 and SHC. This interaction was modeled on a demonstrated interaction between rat IRS-1 and human SHC | BIND | 9202037 |
- | HPRD,BioGRID | 7499194 |
IRS2 | - | insulin receptor substrate 2 | - | HPRD | 11505033 |
ITGB3 | CD61 | GP3A | GPIIIa | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | Integrin-beta-3 interacts with Shc. | BIND | 10964917 |
ITGB4 | CD104 | integrin, beta 4 | - | HPRD,BioGRID | 11044453 |
JAK2 | JTK10 | Janus kinase 2 (a protein tyrosine kinase) | - | HPRD,BioGRID | 7535773 |9126968
|
KDR | CD309 | FLK1 | VEGFR | VEGFR2 | kinase insert domain receptor (a type III receptor tyrosine kinase) | Affinity Capture-Western | BioGRID | 10319320 |11950700
|
- | HPRD | 10749680 |
LRP1 | A2MR | APOER | APR | CD91 | FLJ16451 | IGFBP3R | LRP | MGC88725 | TGFBR5 | low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) | Affinity Capture-Western Reconstituted Complex | BioGRID | 11854294 |12789267
|
- | HPRD | 12069755 |12789267
|
LTK | TYK1 | leukocyte receptor tyrosine kinase | - | HPRD,BioGRID | 9223670 |
LYN | FLJ26625 | JTK8 | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | - | HPRD,BioGRID | 7650013 |
MAP4K1 | HPK1 | mitogen-activated protein kinase kinase kinase kinase 1 | - | HPRD | 9346925 |
MAPK1 | ERK | ERK2 | ERT1 | MAPK2 | P42MAPK | PRKM1 | PRKM2 | p38 | p40 | p41 | p41mapk | mitogen-activated protein kinase 1 | - | HPRD,BioGRID | 10996427 |
MAPKAPK2 | MK2 | mitogen-activated protein kinase-activated protein kinase 2 | - | HPRD,BioGRID | 15094067 |
MET | AUTS9 | HGFR | RCCP2 | c-Met | met proto-oncogene (hepatocyte growth factor receptor) | - | HPRD | 7731718 |
Affinity Capture-Western | BioGRID | 9660480 |
MME | CALLA | CD10 | DKFZp686O16152 | MGC126681 | MGC126707 | NEP | membrane metallo-endopeptidase | - | HPRD,BioGRID | 9659899 |
MST1R | CD136 | CDw136 | PTK8 | RON | macrophage stimulating 1 receptor (c-met-related tyrosine kinase) | - | HPRD,BioGRID | 8918464 |
NGFR | CD271 | Gp80-LNGFR | TNFRSF16 | p75(NTR) | p75NTR | nerve growth factor receptor (TNFR superfamily, member 16) | - | HPRD,BioGRID | 7541035 |
NTRK1 | DKFZp781I14186 | MTC | TRK | TRK1 | TRKA | p140-TrkA | neurotrophic tyrosine kinase, receptor, type 1 | Shc interacts with Trk. This interaction was modelled on a demonstrated interaction between SHC from rat or mouse and Trk from human. | BIND | 8155326 |
Shc interacts with NGFR. | BIND | 8577769 |
ShcA interacts with TrkA. | BIND | 7542991 |8610109 |8943228 |
Affinity Capture-Western Reconstituted Complex Two-hybrid | BioGRID | 8183561 |9856458 |10092678 |10708759 |12446789 |
NTRK2 | GP145-TrkB | TRKB | neurotrophic tyrosine kinase, receptor, type 2 | Reconstituted Complex | BioGRID | 10092678 |
NTRK3 | TRKC | gp145(trkC) | neurotrophic tyrosine kinase, receptor, type 3 | - | HPRD | 7657612 |
Reconstituted Complex | BioGRID | 10092678 |
PAG1 | CBP | FLJ37858 | MGC138364 | PAG | phosphoprotein associated with glycosphingolipid microdomains 1 | - | HPRD,BioGRID | 10790433 |
PDGFRB | CD140B | JTK12 | PDGF-R-beta | PDGFR | PDGFR1 | platelet-derived growth factor receptor, beta polypeptide | PDGFR interacts with p52Shc | BIND | 8195171 |
PDGFR interacts with p66Shc. | BIND | 8195171 |
- | HPRD,BioGRID | 8195171 |
Autophosphorylated PDGFR interacts with SHC. This interaction was modelled on a demonstrated interaction between human PDGFR and SHC from an unspecified species. | BIND | 8890167 |
PIK3C2B | C2-PI3K | DKFZp686G16234 | phosphoinositide-3-kinase, class 2, beta polypeptide | Reconstituted Complex | BioGRID | 11533253 |
PIK3R1 | GRB1 | p85 | p85-ALPHA | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | Reconstituted Complex | BioGRID | 7537361 |
p85 interacts with Shc. | BIND | 8662998 |
- | HPRD | 8662998 |
PIK3R2 | P85B | p85 | p85-BETA | phosphoinositide-3-kinase, regulatory subunit 2 (beta) | - | HPRD | 8662998 |
PLCG1 | PLC-II | PLC1 | PLC148 | PLCgamma1 | phospholipase C, gamma 1 | Affinity Capture-Western | BioGRID | 8662733 |
PLCG2 | - | phospholipase C, gamma 2 (phosphatidylinositol-specific) | - | HPRD,BioGRID | 10623845 |
PLSCR1 | MMTRA1B | phospholipid scramblase 1 | Affinity Capture-Western Reconstituted Complex | BioGRID | 12009895 |12871937
|
PPP2R5A | B56A | MGC131915 | PR61A | protein phosphatase 2, regulatory subunit B', alpha isoform | - | HPRD | 11884620 |
PRKCD | MAY1 | MGC49908 | PKCD | nPKC-delta | protein kinase C, delta | - | HPRD,BioGRID | 12024011 |
PTK2 | FADK | FAK | FAK1 | pp125FAK | PTK2 protein tyrosine kinase 2 | - | HPRD,BioGRID | 11980671 |
Shc interacts with FAK. This interaction was modeled on a demonstrated interaction between human Shc and mouse FAK. | BIND | 9148935 |
PTK2B | CADTK | CAKB | FADK2 | FAK2 | FRNK | PKB | PTK | PYK2 | RAFTK | PTK2B protein tyrosine kinase 2 beta | - | HPRD | 7544443 |
PTPN11 | BPTP3 | CFC | MGC14433 | NS1 | PTP-1D | PTP2C | SH-PTP2 | SH-PTP3 | SHP2 | protein tyrosine phosphatase, non-receptor type 11 | - | HPRD | 10650943 |
PTPN12 | PTP-PEST | PTPG1 | protein tyrosine phosphatase, non-receptor type 12 | - | HPRD,BioGRID | 7929214 |8626541 |11432829 |
RAPGEF1 | C3G | DKFZp781P1719 | GRF2 | Rap guanine nucleotide exchange factor (GEF) 1 | - | HPRD,BioGRID | 9344843 |
RET | CDHF12 | HSCR1 | MEN2A | MEN2B | MTC1 | PTC | RET-ELE1 | RET51 | ret proto-oncogene | RET9 phosphorylates Shc. | BIND | 9047383 |
- | HPRD,BioGRID | 8183561 |9047384
|
SHCBP1 | FLJ22009 | MGC26900 | PAL | SHC SH2-domain binding protein 1 | - | HPRD,BioGRID | 10086341 |
SOS1 | GF1 | GGF1 | GINGF | HGF | NS4 | son of sevenless homolog 1 (Drosophila) | Affinity Capture-Western | BioGRID | 9344843 |10570290 |10675333 |10783152
|
SOS2 | FLJ25596 | son of sevenless homolog 2 (Drosophila) | Affinity Capture-Western | BioGRID | 10675333 |
SP1 | - | Sp1 transcription factor | - | HPRD | 7933095 |
SRC | ASV | SRC1 | c-SRC | p60-Src | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | Src interacts with Shc. This interaction was modelled on demonstrated interactions between human Src and rat Shc, and between Src from unspecified species and human Shc. | BIND | 7515480 |8939605
|
STAT5A | MGF | STAT5 | signal transducer and activator of transcription 5A | Affinity Capture-Western | BioGRID | 10996427 |
STAT5B | STAT5 | signal transducer and activator of transcription 5B | Affinity Capture-Western | BioGRID | 10996427 |
TPR | - | translocated promoter region (to activated MET oncogene) | - | HPRD | 11896612 |
VAV3 | FLJ40431 | vav 3 guanine nucleotide exchange factor | - | HPRD,BioGRID | 11094073 |
ZAP70 | FLJ17670 | FLJ17679 | SRK | STD | TZK | ZAP-70 | zeta-chain (TCR) associated protein kinase 70kDa | - | HPRD,BioGRID | 8761298 |9685404
|