Gene Page: GLUL

Summary
GeneID  2752
Symbol  GLUL
Synonyms  GLNS|GS|PIG43|PIG59
Description  glutamate-ammonia ligase (glutamine synthetase)
See related  HGNC:4341|MIM:138290|Ensembl:ENSG00000135821|HPRD:00701|
Locus tag  -
Gene type  protein-coding
Map location  1q31
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 1.36 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenics, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.4995 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
EXTL10.830.78
KCNK10.820.77
CAMK1G0.820.76
TOLLIP0.810.80
FHL20.810.73
AGBL40.800.74
CAMK2A0.800.76
KIAA07480.800.71
CHN10.790.77
AGMAT0.790.77
Top 10 negatively co-expressed genes
SH3BP2-0.48-0.56
KIAA1949-0.47-0.40
PDE9A-0.47-0.50
TUBB2B-0.47-0.50
SH2D2A-0.47-0.53
SH2B2-0.46-0.50
PKN1-0.45-0.43
FADS2-0.45-0.42
ZNF300-0.45-0.32
ZNF311-0.45-0.34
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004356glutamate-ammonia ligase activityIEAglutamate (GO term level: 7)-
GO:0016874ligase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006807nitrogen compound metabolic processIEA-
GO:0006542glutamine biosynthetic processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005794Golgi apparatusIDA18029348 
GO:0005737cytoplasmIEA-
GO:0005739mitochondrionIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
DYNLL1DLC1 | DLC8 | DNCL1 | DNCLC1 | LC8 | LC8a | MGC126137 | MGC126138 | PIN | hdlc1dynein, light chain, LC8-type 1-HPRD14760703 
GLULGLNS | GS | PIG43 | PIG59glutamate-ammonia ligase (glutamine synthetase)Two-hybridBioGRID16189514 
NUDT18FLJ22494nudix (nucleoside diphosphate linked moiety X)-type motif 18Two-hybridBioGRID16189514 
PLEKHF2FLJ13187 | PHAFIN2 | ZFYVE18pleckstrin homology domain containing, family F (with FYVE domain) member 2Two-hybridBioGRID16189514 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM 3226All SZGR genes in this pathway
KEGG_ARGININE_AND_PROLINE_METABOLISM 5439All SZGR genes in this pathway
KEGG_NITROGEN_METABOLISM 2316All SZGR genes in this pathway
REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES 200136All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION 1714All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN 634384All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN 526357All SZGR genes in this pathway
PRAMOONJAGO_SOX4_TARGETS_DN 5135All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
HUTTMANN_B_CLL_POOR_SURVIVAL_UP 276187All SZGR genes in this pathway
WANG_LMO4_TARGETS_UP 372227All SZGR genes in this pathway
WANG_CLIM2_TARGETS_UP 269146All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_DN 367220All SZGR genes in this pathway
SMIRNOV_CIRCULATING_ENDOTHELIOCYTES_IN_CANCER_UP 158103All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_3D_DN 3119All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_DN 205127All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_DN 14290All SZGR genes in this pathway
RHEIN_ALL_GLUCOCORTICOID_THERAPY_UP 7841All SZGR genes in this pathway
PAPASPYRIDONOS_UNSTABLE_ATEROSCLEROTIC_PLAQUE_UP 5236All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_UP 557331All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
HAHTOLA_SEZARY_SYNDROM_UP 9858All SZGR genes in this pathway
HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP 6446All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
BARIS_THYROID_CANCER_UP 239All SZGR genes in this pathway
CAVARD_LIVER_CANCER_MALIGNANT_VS_BENIGN 3219All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_UP 309199All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_UP 227137All SZGR genes in this pathway
WOOD_EBV_EBNA1_TARGETS_UP 11071All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_12HR_UP 11679All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_UP 487286All SZGR genes in this pathway
WU_CELL_MIGRATION 184114All SZGR genes in this pathway
COLIN_PILOCYTIC_ASTROCYTOMA_VS_GLIOBLASTOMA_UP 3532All SZGR genes in this pathway
AMIT_SERUM_RESPONSE_40_MCF10A 3221All SZGR genes in this pathway
GOLDRATH_HOMEOSTATIC_PROLIFERATION 171102All SZGR genes in this pathway
LEE_LIVER_CANCER_MYC_UP 5430All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_UP 8758All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
SANSOM_APC_TARGETS_UP 12684All SZGR genes in this pathway
FERRANDO_T_ALL_WITH_MLL_ENL_FUSION_DN 8757All SZGR genes in this pathway
KANG_IMMORTALIZED_BY_TERT_DN 10267All SZGR genes in this pathway
RADMACHER_AML_PROGNOSIS 7852All SZGR genes in this pathway
URS_ADIPOCYTE_DIFFERENTIATION_UP 7451All SZGR genes in this pathway
MARCHINI_TRABECTEDIN_RESISTANCE_UP 2116All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
YAMAZAKI_TCEB3_TARGETS_UP 175116All SZGR genes in this pathway
CHEN_LVAD_SUPPORT_OF_FAILING_HEART_UP 10369All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_MUSCLE_UP 4333All SZGR genes in this pathway
BURTON_ADIPOGENESIS_4 4832All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_DN 165106All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C1 7245All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN 434302All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_UP 7747All SZGR genes in this pathway
LEIN_ASTROCYTE_MARKERS 4235All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP 461298All SZGR genes in this pathway
DAIRKEE_CANCER_PRONE_RESPONSE_BPA 5135All SZGR genes in this pathway
HUANG_FOXA2_TARGETS_UP 4528All SZGR genes in this pathway
LABBE_TARGETS_OF_TGFB1_AND_WNT3A_DN 10868All SZGR genes in this pathway
NAKAMURA_METASTASIS 4728All SZGR genes in this pathway
WEST_ADRENOCORTICAL_CARCINOMA_VS_ADENOMA_DN 2418All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_UP 374247All SZGR genes in this pathway
DAVIES_MULTIPLE_MYELOMA_VS_MGUS_DN 2818All SZGR genes in this pathway
PIONTEK_PKD1_TARGETS_UP 3824All SZGR genes in this pathway
PARK_APL_PATHOGENESIS_DN 5035All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
ZHANG_TLX_TARGETS_60HR_DN 277166All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G56_UP 129All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_UP 176110All SZGR genes in this pathway
COULOUARN_TEMPORAL_TGFB1_SIGNATURE_DN 13899All SZGR genes in this pathway
WOO_LIVER_CANCER_RECURRENCE_DN 8054All SZGR genes in this pathway
YAGI_AML_WITH_11Q23_REARRANGED 351238All SZGR genes in this pathway
KOBAYASHI_EGFR_SIGNALING_24HR_UP 10165All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_UP 207143All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_DN 210141All SZGR genes in this pathway
HAHTOLA_CTCL_CUTANEOUS 2619All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
KARLSSON_TGFB1_TARGETS_DN 207139All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_DN 841431All SZGR genes in this pathway
CHICAS_RB1_TARGETS_SENESCENT 572352All SZGR genes in this pathway
WANG_CLASSIC_ADIPOGENIC_TARGETS_OF_PPARG 2615All SZGR genes in this pathway
SERVITJA_ISLET_HNF1A_TARGETS_DN 10971All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_DN 428246All SZGR genes in this pathway


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