Gene Page: DISC1

Summary
GeneID  27185
Symbol  DISC1
Synonyms  C1orf136|FLJ13381|FLJ21640|FLJ25311|FLJ41105|KIAA0457|SCZD9
Description  disrupted in schizophrenia 1
See related  HGNC:2888|MIM:605210|Ensembl:ENSG00000162946|HPRD:05553|
Locus tag  RP11-98O1.1
Gene type  protein-coding
Map location  1q42.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies3Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenia, schizophrenias, schizophrenic]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 32.3086 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI12812986 |15094396 |17043677 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008150biological_processND-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005813centrosomeIEA-
GO:0005856cytoskeletonIEA-
GO:0005874microtubuleIEA-
GO:0005575cellular_componentND-
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTN2CMD1AAactinin, alpha 2DISC-1 interacts with alpha-actinin 2.BIND12812986 
-HPRD,BioGRID12812986 
ANKHD1MASK | VBARPankyrin repeat and KH domain containing 1DISC-1 interacts with APAP2.BIND12812986 
ATF4CREB-2 | CREB2 | TAXREB67 | TXREBactivating transcription factor 4 (tax-responsive enhancer element B67)-HPRD,BioGRID12812986 
An unspecified isoform of DISC1 interacts with ATF4.BIND14623284 
DISC-1 interacts with ATF4.BIND12812986 
ATF5ATFX | FLJ34666 | HMFN0395activating transcription factor 5-HPRD,BioGRID12812986 
DISC-1 interacts with ATF5.BIND12812986 
ATF7IPFLJ10139 | FLJ10688 | MCAF | p621activating transcription factor 7 interacting proteinDISC-1 interacts with ATF7ip.BIND12812986 
Two-hybridBioGRID12812986 
CCDC141FLJ26337 | FLJ39502 | MGC134803coiled-coil domain containing 141Two-hybridBioGRID12812986 
CEP2903H11Ag | BBS14 | FLJ13615 | FLJ21979 | JBTS5 | JBTS6 | KIAA0373 | LCA10 | MKS4 | NPHP6 | SLSN6 | rd16centrosomal protein 290kDaAn unspecified isoform of DISC1 interacts with KIAA0373.BIND14623284 
CEP63FLJ13386 | MGC78416centrosomal protein 63kDaAffinity Capture-Western
Two-hybrid
BioGRID12812986 
CITCRIK | KIAA0949 | STK21citron (rho-interacting, serine/threonine kinase 21)Two-hybridBioGRID12506198 
COL4A1arrestencollagen, type IV, alpha 1Two-hybridBioGRID12812986 
EIF3AEIF3 | EIF3S10 | KIAA0139 | P167 | TIF32 | eIF3-p170 | eIF3-theta | p180 | p185eukaryotic translation initiation factor 3, subunit AAffinity Capture-Western
Two-hybrid
BioGRID12812986 
EIF3HEIF3S3 | MGC102958 | eIF3-gamma | eIF3-p40eukaryotic translation initiation factor 3, subunit HDISC-1 interacts with EIF3.BIND12812986 
Two-hybridBioGRID12812986 
EPB49DMT | FLJ78462 | FLJ98848erythrocyte membrane protein band 4.9 (dematin)An unspecified isoform of DISC1 interacts with DMT.BIND14623284 
FEZ1-fasciculation and elongation protein zeta 1 (zygin I)-HPRD,BioGRID12874605 
GOLGA2GM130 | MGC20672golgi autoantigen, golgin subfamily a, 2An unspecified isoform of DISC1 interacts with GM130.BIND14623284 
IMMTDKFZp779P1653 | HMP | MGC111146 | P87 | P87/89 | P89 | PIG4 | PIG52inner membrane protein, mitochondrial (mitofilin)An unspecified isoform of DISC1 interacts with IMMT.BIND14623284 
ITSN1ITSN | MGC134948 | MGC134949 | SH3D1A | SH3P17intersectin 1 (SH3 domain protein)DISC-1 interacts with ITSN.BIND12812986 
Two-hybridBioGRID12812986 
KALRNDUET | FLJ16443 | HAPIP | TRAD | duokalirin, RhoGEF kinaseAn unspecified isoform of DISC1 interacts with HAPIP.BIND14623284 
KATNAL1MGC2599katanin p60 subunit A-like 1An unspecified isoform of DISC1 interacts with MGC2599.BIND14623284 
KCNQ5Kv7.5potassium voltage-gated channel, KQT-like subfamily, member 5Two-hybridBioGRID12506198 
KIAA1377-KIAA1377Two-hybridBioGRID12812986 
MAP1AFLJ77111 | MAP1L | MTAP1Amicrotubule-associated protein 1A-HPRD,BioGRID12812986 
DISC-1 interacts with MAP1A.BIND12812986 
MGAT3FLJ43371 | GNT-III | GNT3 | MGC141943 | MGC142278mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferaseAn unspecified isoform of DISC1 interacts with MGAT3.BIND14623284 
MYO1ABBMI | DFNA48 | MIHC | MYHLmyosin IATwo-hybridBioGRID12812986 
NDE1FLJ20101 | HOM-TES-87 | NUDE | NUDE1nudE nuclear distribution gene E homolog 1 (A. nidulans)An unspecified isoform of DISC1 interacts with NUDE.BIND14623284 
NDEL1DKFZp451M0318 | EOPA | MITAP1 | NUDELnudE nuclear distribution gene E homolog (A. nidulans)-like 1-HPRD,BioGRID12506198 
DISC-1 interacts with NUDEL.BIND12812986 
PCNTKEN | MOPD2 | PCN | PCNT2 | PCNTB | PCTN2 | SCKL4pericentrinDISC1 interacts with kendrin.BIND15094396 
PPFIA4-protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4An unspecified isoform of DISC1 interacts with PPFIA4.BIND14623284 
RANBP9RANBPMRAN binding protein 9-HPRD,BioGRID12812986 
DISC-1 interacts with RanBPM.BIND12812986 
RASSF7C11orf13 | HRAS1 | HRC1 | MGC126069 | MGC126070Ras association (RalGDS/AF-6) domain family (N-terminal) member 7Two-hybridBioGRID12812986 
SMARCE1BAF57SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1An unspecified isoform of DISC1 interacts with SMARCE1.BIND14623284 
SPTAN1(ALPHA)II-SPECTRIN | FLJ44613 | NEASspectrin, alpha, non-erythrocytic 1 (alpha-fodrin)An unspecified isoform of DISC1 interacts with SPTAN1.BIND14623284 
SPTBN4KIAA1642 | QV | SPNB4 | SPTBN3spectrin, beta, non-erythrocytic 4-HPRD,BioGRID12506198 |12812986 
DISC-1 interacts with B4 Spectrin.BIND12812986 
SYNE18B | CPG2 | DKFZp781J13156 | FLJ30878 | FLJ41140 | KIAA0796 | KIAA1262 | KIAA1756 | MYNE1 | SCAR8spectrin repeat containing, nuclear envelope 1-HPRD,BioGRID12812986 
TRAF3IP1DKFZp434F124 | MIP-T3 | MIPT3TNF receptor-associated factor 3 interacting protein 1DISC-1 interacts with MIP-T3.BIND12812986 
Affinity Capture-Western
Two-hybrid
BioGRID12812986 
YWHAG14-3-3GAMMAtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide-HPRD,BioGRID12506198 
 
Pathway annotation


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