Gene Page: PTPRC

Summary
GeneID  5788
Symbol  PTPRC
Synonyms  B220|CD45|CD45R|GP180|LCA|LY5|T200
Description  protein tyrosine phosphatase, receptor type, C
See related  HGNC:9666|MIM:151460|Ensembl:ENSG00000081237|HPRD:01050|
Locus tag  -
Gene type  protein-coding
Map location  1q31-q32
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0119 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005001transmembrane receptor protein tyrosine phosphatase activityTAS2845400 
GO:0004872receptor activityIEA-
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI1970422 
GO:0004725protein tyrosine phosphatase activityIEA-
GO:0016787hydrolase activityIEA-
GO:0019901protein kinase bindingIPI14625311 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0002378immunoglobulin biosynthetic processIMP1793833 
GO:0001916positive regulation of T cell mediated cytotoxicityIEA-
GO:0001915negative regulation of T cell mediated cytotoxicityISS-
GO:0001960negative regulation of cytokine mediated signaling pathwayISS-
GO:0006469negative regulation of protein kinase activityIDA9197241 
GO:0006469negative regulation of protein kinase activityISS-
GO:0006470protein amino acid dephosphorylationIEA-
GO:0006470protein amino acid dephosphorylationISS-
GO:0007166cell surface receptor linked signal transductionTAS2845400 
GO:0042098T cell proliferationIEA-
GO:0033261regulation of S phaseIMP1793833 
GO:0051607defense response to virusISS-
GO:0042102positive regulation of T cell proliferationISS-
GO:0050852T cell receptor signaling pathwayIDA10358156 
GO:0050857positive regulation of antigen receptor-mediated signaling pathwayISS-
GO:0030890positive regulation of B cell proliferationIMP1793833 
GO:0030217T cell differentiationISS-
GO:0051209release of sequestered calcium ion into cytosolISS-
GO:0030183B cell differentiationIEA-
GO:0045860positive regulation of protein kinase activityNAS15275963 
GO:0050853B cell receptor signaling pathwayISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA18029348 
GO:0005925focal adhesionISS-
GO:0009897external side of plasma membraneIEA-
GO:0005886plasma membraneEXP11827988 
GO:0005887integral to plasma membraneISS-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CD1DCD1A | MGC34622 | R3CD1d molecule-HPRD,BioGRID10473580 
CD2SRBC | T11CD2 molecule-HPRD,BioGRID1970422 |1976695 
CD22FLJ22814 | MGC130020 | SIGLEC-2 | SIGLEC2CD22 moleculeAffinity Capture-WesternBioGRID10228003 
-HPRD7537381 
CD247CD3-ZETA | CD3H | CD3Q | CD3Z | T3Z | TCRZCD247 molecule-HPRD,BioGRID7526385 
CD28MGC138290 | Tp44CD28 molecule-HPRD1355979 
CD4CD4mutCD4 molecule-HPRD,BioGRID1834739 
CD44CDW44 | CSPG8 | ECMR-III | HCELL | IN | LHR | MC56 | MDU2 | MDU3 | MGC10468 | MIC4 | MUTCH-I | Pgp1CD44 molecule (Indian blood group)Co-fractionationBioGRID9573028 
CD79AIGA | MB-1CD79a molecule, immunoglobulin-associated alpha-HPRD,BioGRID7516335 
CD79BB29 | IGBCD79b molecule, immunoglobulin-associated betaAffinity Capture-WesternBioGRID7516335 
CD8ACD8 | Leu2 | MAL | p32CD8a molecule-HPRD,BioGRID1834739 
DPP4ADABP | ADCP2 | CD26 | DPPIV | TP103dipeptidyl-peptidase 4-HPRD1680916 
FCGR3ACD16 | CD16A | FCG3 | FCGR3 | FCGRIII | FCR-10 | FCRIII | FCRIIIA | IGFR3Fc fragment of IgG, low affinity IIIa, receptor (CD16a)-HPRD,BioGRID8157290 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YES-HPRD9368621 |12589038 
GANABG2AN | GluII | KIAA0088glucosidase, alpha; neutral AB-HPRD,BioGRID9148925 |10921916 
|11564800 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD8570203 
IRS1HIRS-1insulin receptor substrate 1-HPRD,BioGRID8557683 
ITGALCD11A | LFA-1 | LFA1Aintegrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)CD11a interacts with CD45.BIND15946252 
JAK1JAK1A | JAK1B | JTK3Janus kinase 1 (a protein tyrosine kinase)-HPRD11201744 
JAK2JTK10Janus kinase 2 (a protein tyrosine kinase)-HPRD11201744 
JAK3JAK-3 | JAK3_HUMAN | JAKL | L-JAK | LJAKJanus kinase 3 (a protein tyrosine kinase, leukocyte)-HPRD11994288 
LCKYT16 | p56lck | pp58lcklymphocyte-specific protein tyrosine kinase-HPRD,BioGRID8473339 |8576115 
LCP2SLP-76 | SLP76lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)-HPRD,BioGRID8703037 
LGALS1DKFZp686E23103 | GAL1 | GBPlectin, galactoside-binding, soluble, 1-HPRD,BioGRID10490978 
LSM1CASM | YJL124CLSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)-HPRD8980254 
LYNFLJ26625 | JTK8v-yes-1 Yamaguchi sarcoma viral related oncogene homologAffinity Capture-Western
Reconstituted Complex		BioGRID7516335 
MBL2COLEC1 | HSMBPC | MBL | MBP | MBP1 | MGC116832 | MGC116833mannose-binding lectin (protein C) 2, soluble (opsonic defect)-HPRD11564800 
PAEPGD | GdA | GdF | GdS | MGC138509 | MGC142288 | PAEG | PEP | PP14progestagen-associated endometrial protein-HPRD,BioGRID12556471 
PLK3CNK | FNK | PRKpolo-like kinase 3 (Drosophila)Affinity Capture-WesternBioGRID11551930 
PPFIA1FLJ41337 | FLJ42630 | FLJ43474 | LIP.1 | LIP1 | LIPRIN | MGC26800protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1-HPRD,BioGRID9624153 
PPFIBP2Cclp1 | DKFZp781K06126 | MGC42541PTPRF interacting protein, binding protein 2 (liprin beta 2)-HPRD,BioGRID9624153 
PRKCSHAGE-R2 | G19P1 | PCLD | PLD1protein kinase C substrate 80K-H-HPRD,BioGRID9148925 
PTPN6HCP | HCPH | HPTP1C | PTP-1C | SH-PTP1 | SHP-1 | SHP-1L | SHP1protein tyrosine phosphatase, non-receptor type 6-HPRD9368621 |10228003 
PTPRCAPCD45-AP | LPAP | MGC138602 | MGC138603protein tyrosine phosphatase, receptor type, C-associated protein-HPRD,BioGRID8537410 
RASA1CM-AVM | CMAVM | DKFZp434N071 | GAP | PKWS | RASA | RASGAP | p120GAP | p120RASGAPRAS p21 protein activator (GTPase activating protein) 1-HPRD8570203 
SEMA4DC9orf164 | CD100 | FLJ33485 | FLJ34282 | FLJ39737 | FLJ46484 | M-sema-G | MGC169138 | MGC169141 | SEMAJ | coll-4sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D-HPRD,BioGRID8955171 |11254687 
SKAP1SCAP1 | SKAP55src kinase associated phosphoprotein 1-HPRD,BioGRID11909961 
SLAMF1CD150 | CDw150 | SLAMsignaling lymphocytic activation molecule family member 1Affinity Capture-WesternBioGRID10229804 
VAV1VAVvav 1 guanine nucleotide exchange factor-HPRD8570203 
ZAP70FLJ17670 | FLJ17679 | SRK | STD | TZK | ZAP-70zeta-chain (TCR) associated protein kinase 70kDa-HPRD,BioGRID7737297 
 


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