Gene Page: ABI1

Summary
GeneID  10006
Symbol  ABI1
Synonyms  ABI-1|E3B1|NAP1BP|SSH3BP|SSH3BP1
Description  abl-interactor 1
See related  HGNC:11320|MIM:603050|Ensembl:ENSG00000136754|HPRD:04336|
Locus tag  RP13-16H11.4
Gene type  protein-coding
Map location  10p11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0008092cytoskeletal protein bindingTAS9593709 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayTAS9010225 
GO:0008285negative regulation of cell proliferationTAS9010225 
GO:0018108peptidyl-tyrosine phosphorylationIDA17101133 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0019717synaptosomeIEASynap, Brain (GO term level: 7)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0005829cytosolTAS9010225 
GO:0005856cytoskeletonIEA-
GO:0005622intracellularIDA17101133 
GO:0005625soluble fractionTAS9010225 
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-
GO:0005783endoplasmic reticulumTAS9593709 
GO:0030027lamellipodiumIDA17101133 
GO:0030054cell junctionIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinase-HPRD9010225 |12672821 
hNap1BP interacts with Abl.BIND11418237 
Affinity Capture-Western
Reconstituted Complex		BioGRID9010225 |11418237 
|12672821 
DNM2CMTDI1 | CMTDIB | DI-CMTB | DYN2 | DYNIIdynamin 2An unspecified isoform of Dyn2 interacts with Abi-1. This interaction was modeled on a demonstrated interaction between human Dyn2 and Abi-1 from an unspecified species.BIND15696170 
ENAHENA | MENA | NDPP1enabled homolog (Drosophila)-HPRD,BioGRID12672821 
EPS8-epidermal growth factor receptor pathway substrate 8-HPRD1049958 |9010225 
|11099046 |12127568 
Affinity Capture-Western
Reconstituted Complex		BioGRID9010225 |11099046 
|14565974 
EPS8L1DRC3 | EPS8R1 | FLJ20258 | MGC23164 | MGC4642 | PP10566EPS8-like 1-HPRD,BioGRID14565974 
EPS8L2EPS8R2 | FLJ16738 | FLJ21935 | FLJ22171 | MGC126530 | MGC3088EPS8-like 2Affinity Capture-WesternBioGRID14565974 
EPS8L3EPS8R3 | FLJ21522 | MGC16817EPS8-like 3Affinity Capture-WesternBioGRID14565974 
HSPA8HSC54 | HSC70 | HSC71 | HSP71 | HSP73 | HSPA10 | LAP1 | MGC131511 | MGC29929 | NIP71heat shock 70kDa protein 8-HPRD15048123 
NCF1CSH3PXD1Cneutrophil cytosolic factor 1C pseudogeneABI-1 interacts with p47phox.BIND12681507 
NCK1MGC12668 | NCK | NCKalphaNCK adaptor protein 1-HPRD,BioGRID11418237 
NCK2GRB4 | NCKbetaNCK adaptor protein 2-HPRD11557983 
NCKAP1FLJ11291 | HEM2 | KIAA0587 | MGC8981 | NAP1 | NAP125NCK-associated protein 1Affinity Capture-Western
Two-hybrid		BioGRID11418237 
Nap1 interacts with hNap1BP.BIND11418237 
NINKIAA1565ninein (GSK3B interacting protein)-HPRD15048123 
PAK2PAK65 | PAKgammap21 protein (Cdc42/Rac)-activated kinase 2-HPRD11956071 
SOS1GF1 | GGF1 | GINGF | HGF | NS4son of sevenless homolog 1 (Drosophila)-HPRD,BioGRID10499589 
SOS2FLJ25596son of sevenless homolog 2 (Drosophila)-HPRD11003655 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_ECADHERIN_NASCENT_AJ_PATHWAY 3933All SZGR genes in this pathway
PID_ERBB1_DOWNSTREAM_PATHWAY 10578All SZGR genes in this pathway
PID_PDGFRB_PATHWAY 129103All SZGR genes in this pathway
PID_ECADHERIN_STABILIZATION_PATHWAY 4234All SZGR genes in this pathway
PID_RAC1_REG_PATHWAY 3825All SZGR genes in this pathway
PID_INTEGRIN_A4B1_PATHWAY 3324All SZGR genes in this pathway
PID_RAC1_PATHWAY 5437All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN 634384All SZGR genes in this pathway
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_UP 255177All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
XU_AKT1_TARGETS_6HR 2718All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP 424268All SZGR genes in this pathway
KENNY_CTNNB1_TARGETS_UP 5030All SZGR genes in this pathway
CHANG_POU5F1_TARGETS_UP 1510All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN 434302All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_8D 882506All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-181131137m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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