Gene Page: PDCD6

Summary
GeneID  10016
Symbol  PDCD6
Synonyms  ALG-2|FLJ46208|MGC111017|MGC119050|MGC9123|PEF1B
Description  programmed cell death 6
See related  HGNC:8765|MIM:601057|Ensembl:ENSG00000063438|HPRD:03035|
Locus tag  -
Gene type  protein-coding
Map location  5p15.33
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0387 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
LY960.850.80
CGRRF10.840.74
PXMP30.810.76
SCRG10.780.69
LST10.740.77
PIGB0.740.68
NDUFB10.740.56
MTCP1NB0.710.64
C18orf320.710.49
MED310.700.52
Top 10 negatively co-expressed genes
CDC2L2-0.59-0.65
SUPT6H-0.58-0.62
MYO18A-0.58-0.59
TNKS1BP1-0.58-0.65
SAFB2-0.58-0.63
HNRNPUL2-0.57-0.57
SART1-0.56-0.64
LONP1-0.56-0.53
PELP1-0.56-0.65
DDX42-0.55-0.56
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005509calcium ion bindingISS-
GO:0048306calcium-dependent protein bindingIPI17196169 |17214967 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006915apoptosisIEA-
GO:0008624induction of apoptosis by extracellular signalsTAS8560270 
GO:0051592response to calcium ionISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005789endoplasmic reticulum membraneIEA-
GO:0005634nucleusIDA17196169 
GO:0005783endoplasmic reticulumIDA17196169 
GO:0016020membraneIEA-
GO:0031965nuclear membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ANXA11ANX11 | CAP50annexin A11-HPRD,BioGRID11883939 
CPNE1COPN1 | CPN1 | MGC1142copine I-HPRD12522145 
CPNE2COPN2 | CPN2 | DKFZp686E06199 | MGC16924copine II-HPRD12522145 
CPNE4COPN4 | CPN4 | MGC15604copine IV-HPRD12522145 
FASALPS1A | APO-1 | APT1 | CD95 | FAS1 | FASTM | TNFRSF6Fas (TNF receptor superfamily, member 6)-HPRD,BioGRID11606059 
FASLGAPT1LG1 | CD178 | CD95L | FASL | TNFSF6Fas ligand (TNF superfamily, member 6)-HPRD11606059 
HEBP2C6ORF34B | C6orf34 | KIAA1244 | PP23 | SOULheme binding protein 2Two-hybridBioGRID16189514 
MAP3K5ASK1 | MAPKKK5 | MEKK5mitogen-activated protein kinase kinase kinase 5-HPRD,BioGRID12372597 
MAPK1IP1LC14orf32 | MGC23138 | MISS | c14_5346mitogen-activated protein kinase 1 interacting protein 1-likeTwo-hybridBioGRID16189514 
PDCD6ALG-2 | FLJ46208 | MGC111017 | MGC119050 | MGC9123 | PEF1Bprogrammed cell death 6Two-hybridBioGRID16189514 
PDCD6IPAIP1 | Alix | DRIP4 | HP95 | MGC17003programmed cell death 6 interacting protein-HPRD,BioGRID9880530 
PEF1PEF1A | PEFLINpenta-EF-hand domain containing 1-HPRD,BioGRID11278427 
SH3KBP1CIN85 | GIG10 | MIG18SH3-domain kinase binding protein 1-HPRD,BioGRID10858458 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_UP 305185All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_UP 430232All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_DN 406230All SZGR genes in this pathway
LAU_APOPTOSIS_CDKN2A_UP 5540All SZGR genes in this pathway
LI_AMPLIFIED_IN_LUNG_CANCER 178108All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_UP 769437All SZGR genes in this pathway
LOCKWOOD_AMPLIFIED_IN_LUNG_CANCER 214139All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX 795478All SZGR genes in this pathway
KOYAMA_SEMA3B_TARGETS_DN 411249All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN 517309All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_5P15_AMPLICON 2615All SZGR genes in this pathway
NIKOLSKY_MUTATED_AND_AMPLIFIED_IN_BREAST_CANCER 9460All SZGR genes in this pathway
DING_LUNG_CANCER_EXPRESSION_BY_COPY_NUMBER 10062All SZGR genes in this pathway
ONDER_CDH1_TARGETS_1_UP 14085All SZGR genes in this pathway
GOLDRATH_HOMEOSTATIC_PROLIFERATION 171102All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
MOREAUX_MULTIPLE_MYELOMA_BY_TACI_UP 412249All SZGR genes in this pathway
MOREAUX_MULTIPLE_MYELOMA_BY_TACI_DN 172107All SZGR genes in this pathway
KUMAR_TARGETS_OF_MLL_AF9_FUSION 405264All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_DN 408274All SZGR genes in this pathway
KAAB_FAILED_HEART_ATRIUM_DN 14199All SZGR genes in this pathway
BACOLOD_RESISTANCE_TO_ALKYLATING_AGENTS_DN 6045All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_5 482296All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING 510309All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
GRADE_COLON_AND_RECTAL_CANCER_UP 285167All SZGR genes in this pathway
MOOTHA_PGC 420269All SZGR genes in this pathway
AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_UP 298174All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_12 7954All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_AND_SATB1_DN 180116All SZGR genes in this pathway
RATTENBACHER_BOUND_BY_CELF1 467251All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.1381387m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/5063803871A,m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-1374334401A,m8hsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-183227233m8hsa-miR-183UAUGGCACUGGUAGAAUUCACUG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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