Gene Page: CDK8

Summary
GeneID  1024
Symbol  CDK8
Synonyms  K35|MGC126074|MGC126075
Description  cyclin-dependent kinase 8
See related  HGNC:1779|MIM:603184|Ensembl:ENSG00000132964|HPRD:04422|
Locus tag  -
Gene type  protein-coding
Map location  13q12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
NACC20.640.70
CCND10.640.66
AC004690.20.630.68
SLC20A20.620.66
ZCCHC240.610.69
TNS10.590.67
ATP10A0.590.63
BCL2L20.590.64
AMPD30.590.63
FAM102A0.590.66
Top 10 negatively co-expressed genes
NR2C2AP-0.44-0.47
TRNAU1AP-0.42-0.44
POLB-0.42-0.48
RPL5-0.42-0.52
EXOSC8-0.41-0.52
COMMD3-0.41-0.49
ZNF124-0.41-0.39
C17orf48-0.41-0.46
ZNF300-0.41-0.35
BZW2-0.41-0.39
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004693cyclin-dependent protein kinase activityIEAneuron (GO term level: 8)-
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIPI7568034 
GO:0005524ATP bindingIEA-
GO:0004672protein kinase activityIEA-
GO:0016740transferase activityIEA-
GO:0008353RNA polymerase subunit kinase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006350transcriptionIEA-
GO:0006468protein amino acid phosphorylationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000119mediator complexIDA14638676 
GO:0005634nucleusIDA16109376 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onsetCo-purificationBioGRID9159119 
CCNCCycCcyclin C-HPRD7568034 |11416138 
Affinity Capture-Western
Co-fractionation
in vitro
in vivo		BioGRID7568034 |9150135 
|9710619 |11416138 
CDKN2BCDK4I | INK4B | MTS2 | P15 | TP15 | p15INK4bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)-HPRD12007796 
CEBPBC/EBP-beta | CRP2 | IL6DBP | LAP | MGC32080 | NF-IL6 | TCF5CCAAT/enhancer binding protein (C/EBP), betaAffinity Capture-WesternBioGRID14759369 
CREBBPCBP | KAT3A | RSTSCREB binding proteinAffinity Capture-Western
Co-fractionation		BioGRID9710619 
KAT2BCAF | P | P/CAF | PCAFK(lysine) acetyltransferase 2BAffinity Capture-WesternBioGRID9710619 
MAML1KIAA0200 | Mam-1 | Mam1mastermind-like 1 (Drosophila)CDK8 interacts with MAM.BIND15546612 
MED1CRSP1 | CRSP200 | DRIP205 | DRIP230 | MGC71488 | PBP | PPARBP | PPARGBP | RB18A | TRAP220 | TRIP2mediator complex subunit 1Affinity Capture-MSBioGRID10198638 
MED10L6 | MGC5309 | NUT2 | TRG20mediator complex subunit 10Affinity Capture-MS
Affinity Capture-Western		BioGRID10198638 |15175163 
MED12CAGH45 | HOPA | KIAA0192 | OPA1 | TNRC11 | TRAP230mediator complex subunit 12Affinity Capture-MSBioGRID10198638 
MED13ARC250 | DRIP250 | HSPC221 | KIAA0593 | THRAP1 | TRAP240mediator complex subunit 13Affinity Capture-MSBioGRID10198638 
MED14CRSP150 | CRSP2 | CSRP | CXorf4 | DRIP150 | EXLM1 | MGC104513 | RGR1 | TRAP170mediator complex subunit 14Affinity Capture-MS
Affinity Capture-Western		BioGRID10198638 |11416138 
MED16DRIP92 | THRAP5 | TRAP95mediator complex subunit 16Affinity Capture-MSBioGRID10198638 
MED17CRSP6 | CRSP77 | DRIP80 | FLJ10812 | TRAP80mediator complex subunit 17Affinity Capture-MSBioGRID10198638 
MED19DT2P1G7 | LCMR1mediator complex subunit 19Affinity Capture-MSBioGRID15175163 
MED21SRB7 | SURB7mediator complex subunit 21Affinity Capture-MS
Affinity Capture-Western
Co-fractionation		BioGRID9315662 |9710619 
|10198638 
MED23CRSP130 | CRSP133 | CRSP3 | DKFZp434H0117 | DRIP130 | SUR2mediator complex subunit 23Affinity Capture-WesternBioGRID11416138 
MED24ARC100 | CRSP100 | CRSP4 | DRIP100 | KIAA0130 | MGC8748 | THRAP4 | TRAP100mediator complex subunit 24Affinity Capture-MSBioGRID10198638 
MED25ACID1 | ARC92 | DKFZp434K0512 | MGC70671 | P78 | PTOV2 | TCBAP0758mediator complex subunit 25-HPRD,BioGRID14983011 
MED26CRSP7 | CRSP70mediator complex subunit 26Affinity Capture-MS
Affinity Capture-Western		BioGRID15175163 
MED281500003D12Rik | DKFZp434N185 | EG1 | magicinmediator complex subunit 28Affinity Capture-MSBioGRID15175163 
MED29DKFZp434H247 | IXLmediator complex subunit 29Affinity Capture-MSBioGRID15175163 
-HPRD14576168 
MED313110004H13Rik | CGI-125 | FLJ27436 | FLJ36714 | Soh1mediator complex subunit 31Affinity Capture-MSBioGRID10198638 
MED6NY-REN-28mediator complex subunit 6Affinity Capture-MS
Affinity Capture-Western		BioGRID10198638 |11416138 
|14983011 
MED9FLJ10193 | MED25 | MGC138234mediator complex subunit 9-HPRD14638676 
Affinity Capture-MSBioGRID15175163 
POLR2AMGC75453 | POLR2 | POLRA | RPB1 | RPBh1 | RPO2 | RPOL2 | RpIILS | hRPB220 | hsRPB1polymerase (RNA) II (DNA directed) polypeptide A, 220kDa-HPRD,BioGRID9443979 
SMARCA2BAF190 | BRM | FLJ36757 | MGC74511 | SNF2 | SNF2L2 | SNF2LA | SWI2 | Sth1p | hBRM | hSNF2aSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2Co-fractionationBioGRID9710619 
SMARCB1BAF47 | INI1 | RDT | SNF5 | SNF5L1 | Sfh1p | Snr1 | hSNFSSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1Affinity Capture-Western
Co-fractionation		BioGRID9710619 
SMARCC1BAF155 | CRACC1 | Rsc8 | SRG3 | SWI3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1Co-fractionationBioGRID9710619 
SMARCC2BAF170 | CRACC2 | Rsc8SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2Co-fractionationBioGRID9710619 
TCEA1GTF2S | SII | TCEA | TF2S | TFIIStranscription elongation factor A (SII), 1Reconstituted ComplexBioGRID9305922 
THRAAR7 | EAR7 | ERB-T-1 | ERBA | ERBA1 | MGC000261 | MGC43240 | NR1A1 | THRA1 | THRA2 | c-ERBA-1thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)Affinity Capture-WesternBioGRID10198638 
THRAP3FLJ22082 | MGC133082 | MGC133083 | TRAP150thyroid hormone receptor associated protein 3Affinity Capture-MSBioGRID10198638 
 


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