Gene Page: UNC13B

Summary
GeneID  10497
Symbol  UNC13B
Synonyms  MGC133279|MGC133280|MUNC13|UNC13|Unc13h2|hmunc13
Description  unc-13 homolog B (C. elegans)
See related  HGNC:12566|MIM:605836|Ensembl:ENSG00000198722|HPRD:05785|
Locus tag  -
Gene type  protein-coding
Map location  9p12-p11
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ZFP620.930.78
TET10.920.81
EPB410.920.75
SMARCC10.910.82
IGF2BP30.910.85
CCDC1230.910.86
FUBP10.910.80
CASP20.910.80
LRIG20.910.74
NONO0.910.81
Top 10 negatively co-expressed genes
FBXO2-0.68-0.76
C5orf53-0.67-0.81
LHPP-0.67-0.65
HLA-F-0.67-0.74
TNFSF12-0.66-0.71
ALDOC-0.66-0.74
LDHD-0.66-0.72
PTH1R-0.66-0.68
AIFM3-0.65-0.71
SLC16A11-0.65-0.67
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityTAS9607201 
GO:0008270zinc ion bindingIEA-
GO:0019992diacylglycerol bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007268synaptic transmissionIEAneuron, Synap, Neurotransmitter (GO term level: 6)-
GO:0016082synaptic vesicle primingIEASynap (GO term level: 10)-
GO:0007242intracellular signaling cascadeIEA-
GO:0006917induction of apoptosisTAS10233166 
GO:0007588excretionTAS9607201 
GO:0006887exocytosisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0005794Golgi apparatusTAS9607201 
GO:0005737cytoplasmTAS10233166 
GO:0005886plasma membraneIEA-
GO:0030054cell junctionIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
DOC2A-double C2-like domains, alpha-HPRD,BioGRID9195900 |9736751 
DOC2B-double C2-like domains, beta-HPRD,BioGRID9195900 |10488064 
RIMS1CORD7 | KIAA0340 | MGC167823 | MGC176677 | RAB3IP2 | RIM | RIM1regulating synaptic membrane exocytosis 1-HPRD,BioGRID11343654 
RPH3ALNOC2rabphilin 3A-like (without C2 domains)-HPRD,BioGRID14593078 
SNAP25FLJ23079 | RIC-4 | RIC4 | SEC9 | SNAP | SNAP-25 | bA416N4.2 | dJ1068F16.2synaptosomal-associated protein, 25kDaCo-fractionationBioGRID8999968 
SPTBN2GTRAP41 | SCA5spectrin, beta, non-erythrocytic 2Two-hybridBioGRID9704016 
STX1AHPC-1 | STX1 | p35-1syntaxin 1A (brain)-HPRD,BioGRID8999968 
STX1BSTX1B1 | STX1B2syntaxin 1B-HPRD,BioGRID8999968 
VAMP2FLJ11460 | SYB2 | VAMP-2vesicle-associated membrane protein 2 (synaptobrevin 2)Co-fractionationBioGRID8999968 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE 1513All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RELEASE_CYCLE 3430All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_C_UP 170114All SZGR genes in this pathway
HEIDENBLAD_AMPLICON_8Q24_UP 4023All SZGR genes in this pathway
PASQUALUCCI_LYMPHOMA_BY_GC_STAGE_UP 283177All SZGR genes in this pathway
NELSON_RESPONSE_TO_ANDROGEN_UP 8661All SZGR genes in this pathway
LEE_LIVER_CANCER_MYC_E2F1_UP 5634All SZGR genes in this pathway
ALCALAY_AML_BY_NPM1_LOCALIZATION_UP 14083All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_24HR_UP 14896All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN 911527All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN 1011592All SZGR genes in this pathway
MASSARWEH_TAMOXIFEN_RESISTANCE_UP 578341All SZGR genes in this pathway
LABBE_TGFB1_TARGETS_UP 10264All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A4 196124All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1518608671A,m8hsa-miR-151brainACUAGACUGAAGCUCCUUGAGG
miR-18312491255m8hsa-miR-183UAUGGCACUGGUAGAAUUCACUG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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