Gene Page: PMVK

Summary
GeneID  10654
Symbol  PMVK
Synonyms  HUMPMKI|PMK|PMKA|PMKASE
Description  phosphomevalonate kinase
See related  HGNC:9141|MIM:607622|Ensembl:ENSG00000163344|HPRD:07404|
Locus tag  -
Gene type  protein-coding
Map location  1q22
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0235 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00814 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004631phosphomevalonate kinase activityTAS10191291 
GO:0005515protein bindingIPI17353931 
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006468protein amino acid phosphorylationTAS10191291 
GO:0006695cholesterol biosynthetic processIEA-
GO:0006629lipid metabolic processTAS10191291 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIEA-
GO:0005777peroxisomeTAS10191291 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CENPHNNF1 | PMF1centromere protein HAffinity Capture-MSBioGRID17353931 
MLF2NTN4myeloid leukemia factor 2Affinity Capture-MSBioGRID17353931 
MPDU1CDGIF | FLJ14836 | HBEBP2BPA | Lec35 | PQLC5 | SL15mannose-P-dolichol utilization defect 1Affinity Capture-MSBioGRID17353931 
PITPNAMGC99649 | PITPN | VIB1Aphosphatidylinositol transfer protein, alphaAffinity Capture-MSBioGRID17353931 
RASGRF2DKFZp781H1715 | GRF2 | RAS-GRF2Ras protein-specific guanine nucleotide-releasing factor 2Affinity Capture-MSBioGRID17353931 
RGS20RGSZ1 | ZGAP1regulator of G-protein signaling 20Affinity Capture-MSBioGRID17353931 
SSBLARP3 | LaSjogren syndrome antigen B (autoantigen La)Affinity Capture-MSBioGRID17353931 
TBPL1MGC:8389 | MGC:9620 | STUD | TLF | TLP | TRF2TBP-like 1Affinity Capture-MSBioGRID17353931 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS 1510All SZGR genes in this pathway
KEGG_PEROXISOME 7847All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 478302All SZGR genes in this pathway
REACTOME_CHOLESTEROL_BIOSYNTHESIS 2416All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_DN 6439All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_DN 7550All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP 530342All SZGR genes in this pathway
LOCKWOOD_AMPLIFIED_IN_LUNG_CANCER 214139All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_1Q21_AMPLICON 3818All SZGR genes in this pathway
CHEOK_RESPONSE_TO_MERCAPTOPURINE_DN 2215All SZGR genes in this pathway
SMITH_LIVER_CANCER 4527All SZGR genes in this pathway
JAIN_NFKB_SIGNALING 7544All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN 1011592All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1 528324All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
LU_EZH2_TARGETS_UP 295155All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_EARLY_LATE 317190All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_AND_SATB1_DN 180116All SZGR genes in this pathway
DURAND_STROMA_S_UP 297194All SZGR genes in this pathway
HORTON_SREBF_TARGETS 2520All SZGR genes in this pathway


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