Gene Page: CFL1

Summary
GeneID  1072
Symbol  CFL1
Synonyms  CFL
Description  cofilin 1 (non-muscle)
See related  HGNC:1874|MIM:601442|Ensembl:ENSG00000172757|HPRD:03261|
Locus tag  -
Gene type  protein-coding
Map location  11q13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0832 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
DGKB0.710.60
HTR40.680.54
IL17RA0.670.55
ANO30.670.52
PDE7B0.660.62
LOXHD10.660.54
SCN4B0.650.51
ST8SIA30.650.51
PDE1B0.640.53
LINGO30.640.52
Top 10 negatively co-expressed genes
EMID1-0.35-0.51
RPL12-0.35-0.53
ALKBH2-0.35-0.44
NR2C2AP-0.34-0.41
UBE2L6-0.34-0.44
CCDC28B-0.34-0.52
RPL36-0.34-0.54
TRNAU1AP-0.34-0.38
TRAF4-0.34-0.48
RPL35-0.34-0.53
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003779actin bindingIEA-
GO:0005515protein bindingIPI12361576 |16713569 |17353931 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001755neural crest cell migrationIEA-
GO:0000910cytokinesisIEA-
GO:0001842neural fold formationIEA-
GO:0030010establishment of cell polarityIEA-
GO:0007266Rho protein signal transductionTAS10436159 
GO:0007015actin filament organizationIEA-
GO:0006928cell motionIEA-
GO:0006916anti-apoptosisTAS16130169 
GO:0030836positive regulation of actin filament depolymerizationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005856cytoskeletonIEA-
GO:0005622intracellularIEA-
GO:0005634nucleusTAS16130169 
GO:0005737cytoplasmTAS16130169 
GO:0016363nuclear matrixIEA-
GO:0030864cortical actin cytoskeletonIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTA1ACTA | ASMA | CFTD | CFTD1 | CFTDM | MPFD | NEM1 | NEM2 | NEM3actin, alpha 1, skeletal muscleAffinity Capture-MSBioGRID11950878 
-HPRD11707283 
ACTA2AAT6 | ACTSAactin, alpha 2, smooth muscle, aorta-HPRD11707283 
ACTBPS1TP5BP1actin, betaTwo-hybridBioGRID16189514 
ACTC1ACTC | CMD1R | CMH11actin, alpha, cardiac muscle 1-HPRD12207032 
ACTG1ACT | ACTG | DFNA20 | DFNA26actin, gamma 1Two-hybridBioGRID16189514 
ATP1A1MGC3285 | MGC51750ATPase, Na+/K+ transporting, alpha 1 polypeptide-HPRD11139403 
CAP1CAP | CAP1-PENCAP, adenylate cyclase-associated protein 1 (yeast)-HPRD,BioGRID11950878 
HSPH1DKFZp686M05240 | HSP105 | HSP105A | HSP105B | KIAA0201 | NY-CO-25heat shock 105kDa/110kDa protein 1Reconstituted Complex
Two-hybrid		BioGRID14733918 
LIMK1LIMKLIM domain kinase 1-HPRD9655398 
Biochemical ActivityBioGRID10436159 |12963706 
LIMK2-LIM domain kinase 2Affinity Capture-WesternBioGRID10436159 
MYCBPAMY-1c-myc binding proteinTwo-hybridBioGRID16169070 
ROCK1MGC131603 | MGC43611 | P160ROCK | PRO0435Rho-associated, coiled-coil containing protein kinase 1Affinity Capture-WesternBioGRID10436159 
SSH1FLJ38102 | KIAA1298 | SSH-1slingshot homolog 1 (Drosophila)Unphosphorylated SSH-1L interacts with and dephosphorylates cofilin.BIND15660133 
TAGLNDKFZp686P11128 | SM22 | SMCC | TAGLN1 | WS3-10transgelinAffinity Capture-MSBioGRID17353931 
TPI1MGC88108 | TPItriosephosphate isomerase 1-HPRD,BioGRID12359716 
TXNDC17MGC14353 | TRP14 | TXNL5thioredoxin domain containing 17Affinity Capture-MSBioGRID14607843 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_AXON_GUIDANCE 129103All SZGR genes in this pathway
KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 9771All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
BIOCARTA_CCR3_PATHWAY 2321All SZGR genes in this pathway
BIOCARTA_RAC1_PATHWAY 2316All SZGR genes in this pathway
BIOCARTA_RHO_PATHWAY 3223All SZGR genes in this pathway
SIG_CHEMOTAXIS 4537All SZGR genes in this pathway
SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES 3525All SZGR genes in this pathway
SA_FAS_SIGNALING 95All SZGR genes in this pathway
SA_G1_AND_S_PHASES 1510All SZGR genes in this pathway
PID_RHOA_PATHWAY 4533All SZGR genes in this pathway
PID_CDC42_PATHWAY 7051All SZGR genes in this pathway
PID_CXCR4_PATHWAY 10278All SZGR genes in this pathway
PID_RAC1_PATHWAY 5437All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ 8956All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE 251188All SZGR genes in this pathway
REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION 1514All SZGR genes in this pathway
REACTOME_SEMAPHORIN_INTERACTIONS 6853All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 208138All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP 530342All SZGR genes in this pathway
MEINHOLD_OVARIAN_CANCER_LOW_GRADE_DN 2016All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN 514330All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS 734436All SZGR genes in this pathway
GNATENKO_PLATELET_SIGNATURE 4828All SZGR genes in this pathway
WIELAND_UP_BY_HBV_INFECTION 10166All SZGR genes in this pathway
NADLER_OBESITY_UP 6134All SZGR genes in this pathway
HILLION_HMGA1_TARGETS 9071All SZGR genes in this pathway
STEARMAN_LUNG_CANCER_EARLY_VS_LATE_DN 6139All SZGR genes in this pathway
HONMA_DOCETAXEL_RESISTANCE 3423All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_UP 14094All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-103/107334340m8hsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-1821351421A,m8hsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-370104110m8hsa-miR-370brainGCCUGCUGGGGUGGAACCUGG
miR-961361421Ahsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.