Gene Page: PTGES3

Summary
GeneID  10728
Symbol  PTGES3
Synonyms  P23|TEBP|cPGES
Description  prostaglandin E synthase 3 (cytosolic)
See related  HGNC:16049|MIM:607061|Ensembl:ENSG00000110958|HPRD:06138|
Locus tag  -
Gene type  protein-coding
Map location  12q13.3|12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0742 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PDYN0.600.63
RARB0.580.63
CDH90.560.62
MPP70.560.72
KCTD80.560.75
VSTM2A0.550.70
AC134043.10.540.20
EBF10.530.29
FLRT30.530.48
HEXB0.530.71
Top 10 negatively co-expressed genes
EMID1-0.38-0.40
METRNL-0.35-0.48
CBS-0.33-0.38
SLA-0.30-0.16
WDR86-0.30-0.32
CSRP2-0.30-0.48
KLHL1-0.30-0.14
SNX7-0.29-0.20
TBC1D10A-0.29-0.30
TMEM108-0.29-0.20
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003720telomerase activityIDA12135483 
GO:0016853isomerase activityIEA-
GO:0050220prostaglandin-E synthase activityIDA10922363 
GO:0051082unfolded protein bindingIDA12077419 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000723telomere maintenanceTAS12135483 
GO:0001516prostaglandin biosynthetic processIDA10922363 
GO:0007165signal transductionTAS8114727 
GO:0006633fatty acid biosynthetic processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000781chromosome, telomeric regionIC12135483 
GO:0005697telomerase holoenzyme complexIDA12135483 
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AHR-aryl hydrocarbon receptor-HPRD11013261 |11259606 
ARNTHIF-1beta | HIF1B | HIF1BETA | TANGO | bHLHe2aryl hydrocarbon receptor nuclear translocator-HPRD11879970 
Reconstituted ComplexBioGRID11259606 
COPGCOPG1 | FLJ21068coatomer protein complex, subunit gamma-HPRD,BioGRID11056392 
COPG22-COP | DKFZp761N09121 | FLJ11781coatomer protein complex, subunit gamma 2-HPRD,BioGRID11056392 
DNAJB1HSPF1 | Hdj1 | Hsp40 | Sis1DnaJ (Hsp40) homolog, subfamily B, member 1-HPRD11809754 
EIF2AK2EIF2AK1 | MGC126524 | PKR | PRKReukaryotic translation initiation factor 2-alpha kinase 2-HPRD,BioGRID11447118 
ERBB3ErbB-3 | HER3 | LCCS2 | MDA-BF-1 | MGC88033 | c-erbB-3 | c-erbB3 | erbB3-S | p180-ErbB3 | p45-sErbB3 | p85-sErbB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)-HPRD10095121 
ESR1DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1estrogen receptor 1Reconstituted ComplexBioGRID9222609 
-HPRD10207098 
FESFPSfeline sarcoma oncogeneReconstituted ComplexBioGRID9222609 
HSF1HSTF1heat shock transcription factor 1Reconstituted ComplexBioGRID9222609 
HSP90AA1FLJ31884 | HSP86 | HSP89A | HSP90A | HSP90N | HSPC1 | HSPCA | HSPCAL1 | HSPCAL4 | HSPN | Hsp89 | Hsp90 | LAP2heat shock protein 90kDa alpha (cytosolic), class A member 1-HPRD,BioGRID11812147 |12077419 
HSPA4APG-2 | HS24/P52 | MGC131852 | RY | hsp70 | hsp70RYheat shock 70kDa protein 4in vivoBioGRID12077419 
NR3C1GCCR | GCR | GR | GRLnuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)-HPRD,BioGRID10691735 
NR3C2MCR | MGC133092 | MLR | MRnuclear receptor subfamily 3, group C, member 2-HPRD,BioGRID10691735 
STIP1HOP | IEF-SSP-3521 | P60 | STI1 | STI1Lstress-induced-phosphoprotein 1-HPRD11809754 
TERTEST2 | TCS1 | TP2 | TRT | hEST2telomerase reverse transcriptase-HPRD,BioGRID11274138 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_TELOMERASE_PATHWAY 6848All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_UP 305185All SZGR genes in this pathway
BIDUS_METASTASIS_UP 214134All SZGR genes in this pathway
MARKEY_RB1_ACUTE_LOF_DN 228137All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_UP 536340All SZGR genes in this pathway
SCHLOSSER_MYC_TARGETS_REPRESSED_BY_SERUM 15993All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
GARCIA_TARGETS_OF_FLI1_AND_DAX1_UP 5734All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN 514330All SZGR genes in this pathway
KOYAMA_SEMA3B_TARGETS_DN 411249All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
SAKAI_TUMOR_INFILTRATING_MONOCYTES_DN 8151All SZGR genes in this pathway
GOLDRATH_HOMEOSTATIC_PROLIFERATION 171102All SZGR genes in this pathway
PENG_LEUCINE_DEPRIVATION_DN 187122All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
PENG_RAPAMYCIN_RESPONSE_DN 245154All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
KEEN_RESPONSE_TO_ROSIGLITAZONE_DN 10668All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_SCC_UP 12375All SZGR genes in this pathway
MARTINEZ_RESPONSE_TO_TRABECTEDIN_DN 271175All SZGR genes in this pathway
VISALA_RESPONSE_TO_HEAT_SHOCK_AND_AGING_DN 1412All SZGR genes in this pathway
ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_UP 17496All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP 973570All SZGR genes in this pathway
MALONEY_RESPONSE_TO_17AAG_DN 7945All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_DN 210128All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP 188121All SZGR genes in this pathway
FOURNIER_ACINAR_DEVELOPMENT_LATE_2 277172All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
DEMAGALHAES_AGING_UP 5539All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-141/200a538544m8hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-186853859m8hsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-24*2622681Ahsa-miR-189GUGCCUACUGAGCUGAUAUCAGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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