Gene Page: IQGAP2

Summary
GeneID  10788
Symbol  IQGAP2
Synonyms  -
Description  IQ motif containing GTPase activating protein 2
See related  HGNC:6111|MIM:605401|Ensembl:ENSG00000145703|HPRD:09253|
Locus tag  -
Gene type  protein-coding
Map location  5q13.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.004 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
DHX90.960.95
PA2G40.960.94
DHX150.960.97
GPN10.960.96
SUPT16H0.950.95
HNRNPK0.950.95
CNOT80.950.95
RBM220.950.94
WDR30.950.95
NOL110.950.95
Top 10 negatively co-expressed genes
MT-CO2-0.80-0.89
AF347015.31-0.80-0.89
AF347015.33-0.79-0.88
AF347015.27-0.78-0.87
MT-CYB-0.77-0.86
AF347015.8-0.77-0.88
FXYD1-0.77-0.88
IFI27-0.76-0.87
AF347015.15-0.75-0.87
AIFM3-0.75-0.81
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005095GTPase inhibitor activityTAS8756646 
GO:0003779actin bindingTAS8756646 
GO:0005099Ras GTPase activator activityIEA-
GO:0005516calmodulin bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007165signal transductionTAS8756646 
GO:0051056regulation of small GTPase mediated signal transductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIEA-
GO:0015629actin cytoskeletonTAS8756646 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTR2ARP2ARP2 actin-related protein 2 homolog (yeast)-HPRD12515716 
CALM1CALML2 | CAMI | DD132 | PHKDcalmodulin 1 (phosphorylase kinase, delta)-HPRD8756646 
CDC42CDC42Hs | G25Kcell division cycle 42 (GTP binding protein, 25kDa)-HPRD8756646 
-HPRD,BioGRID8702968 |8756646|8756646 
HAX1FLJ17042 | FLJ18492 | FLJ93803 | HCLSBP1 | HS1BP1 | SCN3HCLS1 associated protein X-1IQGAP2 interacts with HAX-1.BIND11554782 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-HPRD,BioGRID8702968 |8756646|8756646 
-HPRD8756646 
RELAMGC131774 | NFKB3 | p65v-rel reticuloendotheliosis viral oncogene homolog A (avian)Affinity Capture-MSBioGRID14743216 
RHOGARHG | MGC125835 | MGC125836ras homolog gene family, member G (rho G)Reconstituted ComplexBioGRID12376551 
UBAC1GBDR1 | RP11-432J22.3 | UBADC1UBA domain containing 1Affinity Capture-MSBioGRID17353931 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124/506151157m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-130/3015935991Ahsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-1811391451Ahsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-25/32/92/363/367488494m8hsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-34b599605m8hsa-miR-34bUAGGCAGUGUCAUUAGCUGAUUG
miR-3763333391Ahsa-miR-376aAUCAUAGAGGAAAAUCCACGU
hsa-miR-376bAUCAUAGAGGAAAAUCCAUGUU
miR-4967897951Ahsa-miR-496AUUACAUGGCCAAUCUC
miR-5437998051Ahsa-miR-543AAACAUUCGCGGUGCACUUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.