Gene Page: PPARGC1A

Summary
GeneID  10891
Symbol  PPARGC1A
Synonyms  LEM6|PGC-1(alpha)|PGC-1v|PGC1|PGC1A|PPARGC1
Description  peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
See related  HGNC:9237|MIM:604517|Ensembl:ENSG00000109819|HPRD:05155|
Locus tag  -
Gene type  protein-coding
Map location  4p15.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003677DNA bindingTAS10713165 
GO:0003723RNA bindingTAS12588810 
GO:0008134transcription factor bindingTAS12588810 
GO:0016455RNA polymerase II transcription mediator activityTAS14636573 
GO:0030374ligand-dependent nuclear receptor transcription coactivator activityTAS12588810 
GO:0050681androgen receptor bindingNAS15572661 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001659temperature homeostasisTAS1258810 
GO:0001678cellular glucose homeostasisNAS11854298 
GO:0006367transcription initiation from RNA polymerase II promoterTAS14636573 
GO:0006397mRNA processingTAS12588810 
GO:0008380RNA splicingTAS12588810 
GO:0006461protein complex assemblyTAS14636573 
GO:0007586digestionTAS10585775 
GO:0007005mitochondrion organizationNAS11854298 
GO:0042594response to starvationNAS11854298 
GO:0050821protein stabilizationTAS14636573 
GO:0050873brown fat cell differentiationTAS12588810 
GO:0035066positive regulation of histone acetylationTAS14636573 
GO:0030521androgen receptor signaling pathwayNAS15572661 
GO:0045333cellular respirationTAS11551810 
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA-
GO:0045722positive regulation of gluconeogenesisTAS12588810 
GO:0046321positive regulation of fatty acid oxidationTAS12588810 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusTAS12588810 
GO:0005665DNA-directed RNA polymerase II, core complexTAS12588810 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ESR1DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1estrogen receptor 1-HPRD,BioGRID10748020 
ESRRGDKFZp781L1617 | ERR3 | FLJ16023 | KIAA0832 | NR3B3estrogen-related receptor gamma-HPRD,BioGRID12470660 
HCFC1CFF | HCF-1 | HCF1 | HFC1 | MGC70925 | VCAFhost cell factor C1 (VP16-accessory protein)-HPRD,BioGRID11733490 
MED1CRSP1 | CRSP200 | DRIP205 | DRIP230 | MGC71488 | PBP | PPARBP | PPARGBP | RB18A | TRAP220 | TRIP2mediator complex subunit 1-HPRD,BioGRID14636573 
MED12CAGH45 | HOPA | KIAA0192 | OPA1 | TNRC11 | TRAP230mediator complex subunit 12Affinity Capture-Western
Reconstituted Complex
BioGRID14636573 
MED14CRSP150 | CRSP2 | CSRP | CXorf4 | DRIP150 | EXLM1 | MGC104513 | RGR1 | TRAP170mediator complex subunit 14Affinity Capture-Western
Reconstituted Complex
BioGRID14636573 
MED16DRIP92 | THRAP5 | TRAP95mediator complex subunit 16Affinity Capture-WesternBioGRID14636573 
MED17CRSP6 | CRSP77 | DRIP80 | FLJ10812 | TRAP80mediator complex subunit 17Affinity Capture-Western
Reconstituted Complex
BioGRID14636573 
MED20DKFZp586D2223 | MGC29869 | PRO0213 | TRFPmediator complex subunit 20Affinity Capture-WesternBioGRID14636573 
MED21SRB7 | SURB7mediator complex subunit 21Affinity Capture-WesternBioGRID14636573 
NCLC23 | FLJ45706nucleolin-HPRD10983978 
NCOA1F-SRC-1 | KAT13A | MGC129719 | MGC129720 | NCoA-1 | RIP160 | SRC-1 | SRC1 | bHLHe42nuclear receptor coactivator 1-HPRD,BioGRID10558993 
NR1H4BAR | FXR | HRR-1 | HRR1 | MGC163445 | RIP14nuclear receptor subfamily 1, group H, member 4-HPRD,BioGRID14729567 
NR1I3CAR | CAR1 | MB67 | MGC150433 | MGC97144 | MGC97209nuclear receptor subfamily 1, group I, member 3CAR interacts with PGC-1.BIND15572376 
NR3C1GCCR | GCR | GR | GRLnuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)-HPRD,BioGRID10713165 
NRF1ALPHA-PALnuclear respiratory factor 1-HPRD,BioGRID10412986 |11943463 
PPARAMGC2237 | MGC2452 | NR1C1 | PPAR | hPPARperoxisome proliferator-activated receptor alpha-HPRD,BioGRID10669761 
PPARGNR1C3 | PPARG1 | PPARG2 | PPARgammaperoxisome proliferator-activated receptor gamma-HPRD12502716 
Reconstituted ComplexBioGRID14636573 
RXRAFLJ00280 | FLJ00318 | FLJ16020 | FLJ16733 | MGC102720 | NR2B1retinoid X receptor, alpha-HPRD,BioGRID11714715 
SFRS2PR264 | SC-35 | SC35 | SFRS2A | SRp30bsplicing factor, arginine/serine-rich 2Affinity Capture-WesternBioGRID10983978 
SFRS4SRP75splicing factor, arginine/serine-rich 4Affinity Capture-WesternBioGRID10983978 
SFRS5HRS | SRP40splicing factor, arginine/serine-rich 5Affinity Capture-WesternBioGRID10983978 
SFRS6B52 | FLJ08061 | MGC5045 | SRP55splicing factor, arginine/serine-rich 6Affinity Capture-WesternBioGRID10983978 
THRBERBA-BETA | ERBA2 | GRTH | MGC126109 | MGC126110 | NR1A2 | PRTH | THR1 | THRB1 | THRB2thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)-HPRD,BioGRID11751919 
USF2FIP | bHLHb12upstream transcription factor 2, c-fos interacting-HPRD12611894 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_INSULIN_SIGNALING_PATHWAY 137103All SZGR genes in this pathway
KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY 6757All SZGR genes in this pathway
KEGG_HUNTINGTONS_DISEASE 185109All SZGR genes in this pathway
BIOCARTA_CARM_ER_PATHWAY 3527All SZGR genes in this pathway
BIOCARTA_PPARA_PATHWAY 5843All SZGR genes in this pathway
BIOCARTA_PGC1A_PATHWAY 2620All SZGR genes in this pathway
PID_HDAC_CLASSIII_PATHWAY 2520All SZGR genes in this pathway
PID_MTOR_4PATHWAY 6955All SZGR genes in this pathway
PID_ATF2_PATHWAY 5943All SZGR genes in this pathway
PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY 3829All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION 3627All SZGR genes in this pathway
REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION 10472All SZGR genes in this pathway
REACTOME_RORA_ACTIVATES_CIRCADIAN_EXPRESSION 2417All SZGR genes in this pathway
REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA 2316All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 478302All SZGR genes in this pathway
REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 168115All SZGR genes in this pathway
REACTOME_CIRCADIAN_CLOCK 5340All SZGR genes in this pathway
REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION 7253All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_UP 276165All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_2_UP 13983All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_UP 341197All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_UP 584356All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
HELLER_SILENCED_BY_METHYLATION_DN 10567All SZGR genes in this pathway
WALLACE_PROSTATE_CANCER_RACE_UP 299167All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_DN 540340All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_DN 274165All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_UP 439257All SZGR genes in this pathway
CADWELL_ATG16L1_TARGETS_DN 7043All SZGR genes in this pathway
YAMASHITA_LIVER_CANCER_STEM_CELL_DN 7651All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_PCA3_UP 8054All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_DN 267160All SZGR genes in this pathway
MIKKELSEN_NPC_ICP_WITH_H3K4ME3 445257All SZGR genes in this pathway
YANG_BCL3_TARGETS_UP 364236All SZGR genes in this pathway
GUO_TARGETS_OF_IRS1_AND_IRS2 9867All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_UP 289184All SZGR genes in this pathway
CHEMELLO_SOLEUS_VS_EDL_MYOFIBERS_UP 3516All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/9838441Ahsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-13610921098m8hsa-miR-136ACUCCAUUUGUUUUGAUGAUGGA
miR-137265626621Ahsa-miR-137UAUUGCUUAAGAAUACGCGUAG
hsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-138236023671A,m8hsa-miR-138brainAGCUGGUGUUGUGAAUC
miR-13934533459m8hsa-miR-139brainUCUACAGUGCACGUGUCU
miR-148/15211521158m8hsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-1508058111Ahsa-miR-150UCUCCCAACCCUUGUACCAGUG
miR-15311491155m8hsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-193175417601Ahsa-miR-193aAACUGGCCUACAAAGUCCCAG
hsa-miR-193bAACUGGCCCUCAAAGUCCCGCUUU
miR-194114111471Ahsa-miR-194UGUAACAGCAACUCCAUGUGGA
miR-199148514921A,m8hsa-miR-199aCCCAGUGUUCAGACUACCUGUUC
hsa-miR-199bCCCAGUGUUUAGACUAUCUGUUC
miR-204/211377637831A,m8hsa-miR-204brainUUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211UUCCCUUUGUCAUCCUUCGCCU
miR-2141942001Ahsa-miR-214brainACAGCAGGCACAGACAGGCAG
miR-217374637521Ahsa-miR-217UACUGCAUCAGGAACUGAUUGGAU
miR-218229235m8hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-219698704m8hsa-miR-219brainUGAUUGUCCAAACGCAAUUCU
miR-22232923351Ahsa-miR-22brainAAGCUGCCAGUUGAAGAACUGU
miR-221/222322232291A,m8hsa-miR-221brainAGCUACAUUGUCUGCUGGGUUUC
hsa-miR-222brainAGCUACAUCUGGCUACUGGGUCUC
miR-2335043510m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-2931813187m8hsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
miR-30-5p18501856m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-320253259m8hsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-323354935561A,m8hsa-miR-323brainGCACAUUACACGGUCGACCUCU
hsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-3323252331m8hsa-miR-33GUGCAUUGUAGUUGCAUUG
hsa-miR-33bGUGCAUUGCUGUUGCAUUGCA
miR-369-3p189318991Ahsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-374189319001A,m8hsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-410127512811Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-433-3p15401546m8hsa-miR-433brainAUCAUGAUGGGCUCCUCGGUGU
miR-485-3p371437211A,m8hsa-miR-485-3pGUCAUACACGGCUCUCCUCUCU
miR-485-5p375837651A,m8hsa-miR-485-5pAGAGGCUGGCCGUGAUGAAUUC
miR-494378837951A,m8hsa-miR-494brainUGAAACAUACACGGGAAACCUCUU
miR-495113911451Ahsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
hsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
miR-496155115571Ahsa-miR-496AUUACAUGGCCAAUCUC
miR-5399399m8hsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
hsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
miR-54337863792m8hsa-miR-543AAACAUUCGCGGUGCACUUCU
miR-79119171Ahsa-miR-7SZUGGAAGACUAGUGAUUUUGUUG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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