Gene Page: RIPK3

Summary
GeneID  11035
Symbol  RIPK3
Synonyms  RIP3
Description  receptor-interacting serine-threonine kinase 3
See related  HGNC:10021|MIM:605817|Ensembl:ENSG00000129465|HPRD:09315|
Locus tag  -
Gene type  protein-coding
Map location  14q11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.047 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0122 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0004704NF-kappaB-inducing kinase activityIEA-
GO:0003713transcription coactivator activityTAS10339433 
GO:0005524ATP bindingIEA-
GO:0004674protein serine/threonine kinase activityIEA-
GO:0004674protein serine/threonine kinase activityTAS10339433 
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006464protein modification processTAS10358032 
GO:0006468protein amino acid phosphorylationIEA-
GO:0007165signal transductionTAS10339433 
GO:0006915apoptosisIEA-
GO:0007249I-kappaB kinase/NF-kappaB cascadeIEA-
GO:0008624induction of apoptosis by extracellular signalsTAS10339433 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIEA-
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AIFM1AIF | MGC111425 | PDCD8apoptosis-inducing factor, mitochondrion-associated, 1-HPRD14743216 
ATAD3AFLJ10709ATPase family, AAA domain containing 3A-HPRD14743216 
CAPZBCAPB | CAPPB | CAPZ | MGC104401 | MGC129749 | MGC129750capping protein (actin filament) muscle Z-line, beta-HPRD14743216 
DBN1D0S117E | DKFZp434D064drebrin 1-HPRD14743216 
EEF1DEF-1D | EF1D | FLJ20897 | FP1047eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)-HPRD14743216 
GNG12FLJ31352 | FLJ34695guanine nucleotide binding protein (G protein), gamma 12-HPRD14743216 
HNRNPA1HNRPA1 | MGC102835heterogeneous nuclear ribonucleoprotein A1-HPRD14743216 
HSPA8HSC54 | HSC70 | HSC71 | HSP71 | HSP73 | HSPA10 | LAP1 | MGC131511 | MGC29929 | NIP71heat shock 70kDa protein 8-HPRD14743216 
MPRIPKIAA0864 | M-RIP | RHOIP3 | p116Ripmyosin phosphatase Rho interacting protein-HPRD14743216 
MRCL3MLCB | MRLC3myosin regulatory light chain MRCL3-HPRD14743216 
MYL6ESMLC | LC17-GI | LC17-NM | LC17A | LC17B | MLC1SM | MLC3NM | MLC3SMmyosin, light chain 6, alkali, smooth muscle and non-muscle-HPRD14743216 
RIPK1FLJ39204 | RIP | RIP1receptor (TNFRSF)-interacting serine-threonine kinase 1-HPRD,BioGRID10339433 
SCINKIAA1905scinderin-HPRD14743216 
SPECC1LKIAA0376SPECC1-like-HPRD14743216 
SPTBN1ELF | SPTB2 | betaSpIIspectrin, beta, non-erythrocytic 1-HPRD14743216 
TIAF1MAJN | MYO18A | MYSPDZ | SPR210TGFB1-induced anti-apoptotic factor 1-HPRD14743216 
TICAM1MGC35334 | PRVTIRB | TICAM-1 | TRIFtoll-like receptor adaptor molecule 1-HPRD,BioGRID15064760 
TNFRSF1ACD120a | FPF | MGC19588 | TBP1 | TNF-R | TNF-R-I | TNF-R55 | TNFAR | TNFR1 | TNFR55 | TNFR60 | p55 | p55-R | p60tumor necrosis factor receptor superfamily, member 1A-HPRD,BioGRID10339433 
TPM3FLJ41118 | MGC14582 | MGC3261 | MGC72094 | NEM1 | OK/SW-cl.5 | TM-5 | TM3 | TM30 | TM30nm | TPMsk3 | TRK | hscp30tropomyosin 3-HPRD14743216 
TRAF2MGC:45012 | TRAP | TRAP3TNF receptor-associated factor 2-HPRD,BioGRID10339433 
TUBA3CTUBA2 | bA408E5.3tubulin, alpha 3c-HPRD14743216 
TUBB2BDKFZp566F223 | FLJ98847 | MGC8685 | TUBB-PARALOG | bA506K6.1tubulin, beta 2B-HPRD14743216 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY 5644All SZGR genes in this pathway
REACTOME_TRIF_MEDIATED_TLR3_SIGNALING 7454All SZGR genes in this pathway
REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI 1815All SZGR genes in this pathway
REACTOME_INNATE_IMMUNE_SYSTEM 279178All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
SCHLESINGER_METHYLATED_DE_NOVO_IN_CANCER 8864All SZGR genes in this pathway
ALCALA_APOPTOSIS 8860All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR 532309All SZGR genes in this pathway
FIRESTEIN_PROLIFERATION 175125All SZGR genes in this pathway
COLINA_TARGETS_OF_4EBP1_AND_4EBP2 356214All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_UP 857456All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_8D 882506All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_UP 289184All SZGR genes in this pathway


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