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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: CHD3

Summary

GeneID

1107

Symbol

CHD3

Synonyms

Mi-2a|Mi2-ALPHA|ZFH

Description

chromodomain helicase DNA binding protein 3

Locus tag

Gene type

protein-coding

Map location

17p13.1

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Literature

High-throughput literature-search

Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]

Click to show detail

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.0278

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000166

nucleotide binding

IEA

GO:0003677

DNA binding

TAS

9326634

GO:0003682

chromatin binding

IEA

GO:0004003

ATP-dependent DNA helicase activity

TAS

9326634

GO:0005515

protein binding

IPI

12505151 |15383276

GO:0005524

ATP binding

IEA

GO:0016787

hydrolase activity

IEA

GO:0016818

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

IEA

GO:0008270

zinc ion binding

NAS

9688266

GO:0046872

metal ion binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006333

chromatin assembly or disassembly

IEA

GO:0006357

regulation of transcription from RNA polymerase II promoter

TAS

9326634

GO:0016568

chromatin modification

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000785

chromatin

IEA

GO:0005634

nucleus

NAS

9688266

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ADH5	ADH-3 \| ADHX \| FDH \| GSNOR	alcohol dehydrogenase 5 (class III), chi polypeptide	Two-hybrid	BioGRID	16169070
ARS2	ASR2 \| MGC126427	arsenate resistance protein 2	Two-hybrid	BioGRID	16169070
ATPIF1	ATPI \| ATPIP \| IP \| MGC1167 \| MGC8898	ATPase inhibitory factor 1	Two-hybrid	BioGRID	16169070
BCL6	BCL5 \| BCL6A \| LAZ3 \| ZBTB27 \| ZNF51	B-cell CLL/lymphoma 6	BCL6 interacts with Mi2.	BIND	15454082
BHLHB2	DEC1 \| SHARP-2 \| STRA13 \| Stra14 \| bHLHe40	basic helix-loop-helix domain containing, class B, 2	Two-hybrid	BioGRID	16169070
C4orf17	DKFZp434G072	chromosome 4 open reading frame 17	Two-hybrid	BioGRID	16169070
C7orf36	GK003	chromosome 7 open reading frame 36	Two-hybrid	BioGRID	16169070
CASP6	MCH2	caspase 6, apoptosis-related cysteine peptidase	Two-hybrid	BioGRID	16169070
CASP8	ALPS2B \| CAP4 \| FLICE \| FLJ17672 \| MACH \| MCH5 \| MGC78473	caspase 8, apoptosis-related cysteine peptidase	Two-hybrid	BioGRID	16169070
CPE	-	carboxypeptidase E	Two-hybrid	BioGRID	16169070
CRCT1	C1orf42 \| NICE-1	cysteine-rich C-terminal 1	Two-hybrid	BioGRID	16169070
CREB1	CREB \| MGC9284	cAMP responsive element binding protein 1	Two-hybrid	BioGRID	16169070
CSTF2	CstF-64	cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa	Two-hybrid	BioGRID	16169070
CTTN	EMS1 \| FLJ34459	cortactin	Two-hybrid	BioGRID	16169070
FAM134A	C2orf17 \| DKFZp686C2379 \| MGC3035	family with sequence similarity 134, member A	Two-hybrid	BioGRID	16169070
FBP2	MGC142192	fructose-1,6-bisphosphatase 2	Two-hybrid	BioGRID	16169070
FUBP1	FBP \| FUBP	far upstream element (FUSE) binding protein 1	Two-hybrid	BioGRID	16169070
GPS2	AMF-1 \| MGC104294 \| MGC119287 \| MGC119288 \| MGC119289	G protein pathway suppressor 2	Two-hybrid	BioGRID	16169070
HABP4	IHABP4 \| Ki-1/57 \| MGC825 \| SERBP1L	hyaluronan binding protein 4	-	HPRD,BioGRID	12505151
HABP4	IHABP4 \| Ki-1/57 \| MGC825 \| SERBP1L	hyaluronan binding protein 4	Ki-1/57 interacts with CHD-3.	BIND	12505151
HDAC1	DKFZp686H12203 \| GON-10 \| HD1 \| RPD3 \| RPD3L1	histone deacetylase 1	-	HPRD,BioGRID	9804427
HDAC2	RPD3 \| YAF1	histone deacetylase 2	-	HPRD,BioGRID	9804427
HSPH1	DKFZp686M05240 \| HSP105 \| HSP105A \| HSP105B \| KIAA0201 \| NY-CO-25	heat shock 105kDa/110kDa protein 1	Two-hybrid	BioGRID	16169070
IK	CSA2 \| MGC59741 \| RED	IK cytokine, down-regulator of HLA II	Two-hybrid	BioGRID	16169070
IKZF1	Hs.54452 \| IK1 \| IKAROS \| LYF1 \| PRO0758 \| ZNFN1A1 \| hIk-1	IKAROS family zinc finger 1 (Ikaros)	-	HPRD	10204490
IKZF3	AIO \| AIOLOS \| ZNFN1A3	IKAROS family zinc finger 3 (Aiolos)	-	HPRD	10204490
IMMT	DKFZp779P1653 \| HMP \| MGC111146 \| P87 \| P87/89 \| P89 \| PIG4 \| PIG52	inner membrane protein, mitochondrial (mitofilin)	Two-hybrid	BioGRID	16169070
IVNS1ABP	DKFZp686K06216 \| FLARA3 \| FLJ10069 \| FLJ10411 \| FLJ10962 \| FLJ35593 \| FLJ36593 \| HSPC068 \| KIAA0850 \| ND1 \| NS-1 \| NS1-BP \| NS1BP	influenza virus NS1A binding protein	Two-hybrid	BioGRID	16169070
KIF15	FLJ25667 \| HKLP2 \| KNSL7 \| NY-BR-62	kinesin family member 15	Two-hybrid	BioGRID	16169070
LUC7L2	CGI-59 \| CGI-74 \| FLJ10657 \| LUC7B2	LUC7-like 2 (S. cerevisiae)	Two-hybrid	BioGRID	16169070
MAFG	MGC13090 \| MGC20149	v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)	Two-hybrid	BioGRID	16169070
MAN2A2	MANA2X	mannosidase, alpha, class 2A, member 2	Two-hybrid	BioGRID	16169070
MBD2	DKFZp586O0821 \| DMTase \| NY-CO-41	methyl-CpG binding domain protein 2	Reconstituted Complex	BioGRID	10444591
MBD3L1	MBD3L \| MGC138263 \| MGC138269	methyl-CpG binding domain protein 3-like 1	Affinity Capture-Western	BioGRID	15456747
MTA2	DKFZp686F2281 \| MTA1L1 \| PID	metastasis associated 1 family, member 2	Co-purification	BioGRID	10444591
PAICS	ADE2 \| ADE2H1 \| AIRC \| DKFZp781N1372 \| MGC1343 \| MGC5024 \| PAIS	phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase	Two-hybrid	BioGRID	16169070
PCMT1	-	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Two-hybrid	BioGRID	16169070
PRG2	BMPG \| MBP \| MBP1 \| MGC14537	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)	Two-hybrid	BioGRID	16169070
PRPF40A	FBP-11 \| FBP11 \| FLAF1 \| FLJ20585 \| FNBP3 \| HIP10 \| HYPA \| NY-REN-6	PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)	-	HPRD	15383276
PSME1	IFI5111 \| MGC8628 \| PA28A \| PA28alpha \| REGalpha	proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)	Two-hybrid	BioGRID	16169070
PTN	HARP \| HBGF8 \| HBNF \| NEGF1	pleiotrophin	Two-hybrid	BioGRID	16169070
PTPRS	PTPSIGMA	protein tyrosine phosphatase, receptor type, S	Two-hybrid	BioGRID	16169070
PUF60	FIR \| FLJ31379 \| RoBPI \| SIAHBP1	poly-U binding splicing factor 60KDa	Two-hybrid	BioGRID	16169070
RAD21	FLJ25655 \| FLJ40596 \| HR21 \| HRAD21 \| KIAA0078 \| MCD1 \| NXP1 \| SCC1 \| hHR21	RAD21 homolog (S. pombe)	Co-purification	BioGRID	12198550
RAD51	BRCC5 \| HRAD51 \| HsRad51 \| HsT16930 \| RAD51A \| RECA	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	Two-hybrid	BioGRID	16169070
RPL29	HIP \| HUMRPL29 \| MGC88589	ribosomal protein L29	Two-hybrid	BioGRID	16169070
SAFB	DKFZp779C1727 \| HAP \| HET \| SAFB1	scaffold attachment factor B	Two-hybrid	BioGRID	16169070
SAT1	DC21 \| KFSD \| SAT \| SSAT \| SSAT-1	spermidine/spermine N1-acetyltransferase 1	Two-hybrid	BioGRID	16169070
SATB1	-	SATB homeobox 1	-	HPRD	12374985
SDCCAG3	NY-CO-3	serologically defined colon cancer antigen 3	Two-hybrid	BioGRID	16169070
SERBP1	CGI-55 \| CHD3IP \| DKFZp564M2423 \| FLJ90489 \| HABP4L \| PAI-RBP1 \| PAIRBP1	SERPINE1 mRNA binding protein 1	-	HPRD,BioGRID	12505151
SERBP1		SERPINE1 mRNA binding protein 1	CGI-55 interacts with CHD-3.	BIND	12505151
SERF2	4F5REL \| FAM2C \| FLJ20431 \| FLJ37527 \| FLJ38557 \| H4F5rel \| HsT17089 \| MGC48826	small EDRK-rich factor 2	Two-hybrid	BioGRID	16169070
SGSM2	KIAA0397 \| RUTBC1	small G protein signaling modulator 2	Two-hybrid	BioGRID	16169070
SIRT6	SIR2L6	sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)	Two-hybrid	BioGRID	16169070
SLC27A6	ACSVL2 \| DKFZp779M0564 \| FACVL2 \| FATP6 \| VLCS-H1	solute carrier family 27 (fatty acid transporter), member 6	Two-hybrid	BioGRID	16169070
SMARCA5	ISWI \| SNF2H \| WCRF135 \| hISWI \| hSNF2H	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	Co-purification	BioGRID	12198550
SUMO1	DAP-1 \| GMP1 \| OFC10 \| PIC1 \| SENP2 \| SMT3 \| SMT3C \| SMT3H3 \| SUMO-1 \| UBL1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	SUMO-1 interacts with CHD3.	BIND	14609633
			-	HPRD	14609633
			Two-hybrid	BioGRID	10961991
SUMO2	HSMT3 \| MGC117191 \| SMT3B \| SMT3H2	SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)	Two-hybrid	BioGRID	16169070
THOC7	FLJ23445 \| NIF3L1BP1 \| fSAP24	THO complex 7 homolog (Drosophila)	Two-hybrid	BioGRID	16169070
TNFRSF14	ATAR \| HVEA \| HVEM \| LIGHTR \| TR2	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	Two-hybrid	BioGRID	16169070
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	-	HPRD,BioGRID	10961991
TP73	P73	tumor protein p73	-	HPRD,BioGRID	10961991
TRIM28	FLJ29029 \| KAP1 \| RNF96 \| TF1B \| TIF1B	tripartite motif-containing 28	Two-hybrid	BioGRID	16169070
TSPAN6	T245 \| TM4SF6 \| TSPAN-6	tetraspanin 6	Two-hybrid	BioGRID	16169070
TTR	HsT2651 \| PALB \| TBPA	transthyretin	Two-hybrid	BioGRID	16169070
TXNDC9	APACD	thioredoxin domain containing 9	Two-hybrid	BioGRID	16169070
UBA3	DKFZp566J164 \| MGC22384 \| UBE1C \| hUBA3	ubiquitin-like modifier activating enzyme 3	Two-hybrid	BioGRID	16169070
UBE2I	C358B7.1 \| P18 \| UBC9	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	-	HPRD,BioGRID	14609633
UBE2I	C358B7.1 \| P18 \| UBC9	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	Ubc9 interacts with CHD3.	BIND	14609633
XRCC4	-	X-ray repair complementing defective repair in Chinese hamster cells 4	Two-hybrid	BioGRID	16169070
ZHX1	-	zinc fingers and homeoboxes 1	-	HPRD	15383276

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
PID_HDAC_CLASSI_PATHWAY	66	50	All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP	783	507	All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP	233	161	All SZGR genes in this pathway
HOEBEKE_LYMPHOID_STEM_CELL_UP	95	64	All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_UP	380	236	All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_UP	418	263	All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN	514	330	All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_12HR_DN	57	45	All SZGR genes in this pathway
FLECHNER_PBL_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP	151	100	All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN	434	302	All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP	566	371	All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN	546	362	All SZGR genes in this pathway
ASGHARZADEH_NEUROBLASTOMA_POOR_SURVIVAL_DN	46	30	All SZGR genes in this pathway
KARLSSON_TGFB1_TARGETS_UP	127	78	All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP	745	475	All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3	824	528	All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN	1080	713	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-491	90	96	m8	hsa-miR-491^brain	AGUGGGGAACCCUUCCAUGAGGA
miR-504	252	258	m8	hsa-miR-504	AGACCCUGGUCUGCACUCUAU
miR-7	256	263	1A,m8	hsa-miR-7^SZ	UGGAAGACUAGUGAUUUUGUUG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.