Gene Page: CHRM2

Summary
GeneID  1129
Symbol  CHRM2
Synonyms  FLJ43243|HM2|MGC120006|MGC120007
Description  cholinergic receptor, muscarinic 2
See related  HGNC:1951|MIM:118493|Ensembl:ENSG00000181072|HPRD:00328|
Locus tag  -
Gene type  protein-coding
Map location  7q31-q35
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PLA2G150.860.87
ATP13A20.810.85
GRIN2D0.800.79
PITPNM10.800.79
ORAI20.800.82
GDPD50.790.86
TMEM1630.780.82
ABCA30.780.89
DBNDD10.780.76
AHNAK20.770.82
Top 10 negatively co-expressed genes
AF347015.31-0.53-0.68
COPZ2-0.52-0.67
AF347015.33-0.52-0.66
AC021016.1-0.51-0.70
MT-CO2-0.51-0.67
AF347015.8-0.50-0.66
MT-CYB-0.50-0.65
AF347015.2-0.50-0.62
AF347015.27-0.50-0.66
FXYD1-0.49-0.63
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0004981muscarinic acetylcholine receptor activityTAS9603968 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007399nervous system developmentTASneurite (GO term level: 5)2739737 
GO:0007188G-protein signaling, coupled to cAMP nucleotide second messengerTAS8139539 
GO:0007207muscarinic acetylcholine receptor, phospholipase C activating pathwayTAS2739737 
GO:0007213acetylcholine receptor signaling, muscarinic pathwayIEA-
GO:0007165signal transductionIEA-
GO:0008016regulation of heart contractionTAS10544184 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0045211postsynaptic membraneIEASynap, Neurotransmitter (GO term level: 5)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0005886plasma membraneTAS3443095 
GO:0005887integral to plasma membraneTAS3037705 
GO:0030054cell junctionIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
GNA11GNA-11guanine nucleotide binding protein (G protein), alpha 11 (Gq class)-HPRD7797501 
GNA14-guanine nucleotide binding protein (G protein), alpha 14-HPRD7797501 
GNA15GNA16guanine nucleotide binding protein (G protein), alpha 15 (Gq class)-HPRD7797501 
GNG2-guanine nucleotide binding protein (G protein), gamma 2-HPRD9063897 
GPRASP1GASP | GASP1 | KIAA0443G protein-coupled receptor associated sorting protein 1GASP-1 interacts with M2.BIND15086532 
GPRASP2FLJ35662 | FLJ37327 | GASP2G protein-coupled receptor associated sorting protein 2GASP-2 interacts with M2.BIND15086532 
GRK5GPRK5G protein-coupled receptor kinase 5-HPRD,BioGRID8288567 
SAGARRESTIN | DKFZp686D1084 | DKFZp686I1383 | S-AGS-antigen; retina and pineal gland (arrestin)-HPRD10952973 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CALCIUM_SIGNALING_PATHWAY 178134All SZGR genes in this pathway
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS 305177All SZGR genes in this pathway
REACTOME_AMINE_LIGAND_BINDING_RECEPTORS 3833All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_G_ALPHA_I_SIGNALLING_EVENTS 195114All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_DN 357212All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 419273All SZGR genes in this pathway
KONDO_PROSTATE_CANCER_WITH_H3K27ME3 19693All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-17-5p/20/93.mr/106/519.d92991A,m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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