Gene Page: CHRM5

Summary
GeneID  1133
Symbol  CHRM5
Synonyms  HM5|MGC41838
Description  cholinergic receptor, muscarinic 5
See related  HGNC:1954|MIM:118496|Ensembl:ENSG00000184984|HPRD:00331|
Locus tag  -
Gene type  protein-coding
Map location  15q26
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ADARB10.890.89
MGAT30.880.94
CYFIP20.880.88
NISCH0.880.91
SV2A0.870.89
ZDHHC50.870.90
AP1B10.870.89
AP2A10.870.89
TNFRSF210.870.88
CNNM20.870.90
Top 10 negatively co-expressed genes
AF347015.21-0.60-0.66
AL139819.3-0.59-0.66
AF347015.31-0.59-0.61
GNG11-0.58-0.66
HIGD1B-0.58-0.62
AP002478.3-0.57-0.64
MT-CO2-0.57-0.60
AF347015.2-0.57-0.54
CLDN10-0.56-0.57
AF347015.8-0.56-0.60
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0004981muscarinic acetylcholine receptor activityTAS3272174 
GO:0004435phosphoinositide phospholipase C activityTAS1905013 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0015872dopamine transportIEANeurotransmitter, dopamine (GO term level: 8)-
GO:0019226transmission of nerve impulseIEAneuron (GO term level: 5)-
GO:0007197muscarinic acetylcholine receptor, adenylate cyclase inhibiting pathwayTAS8663391 
GO:0007213acetylcholine receptor signaling, muscarinic pathwayTAS3272174 
GO:0007165signal transductionIEA-
GO:0008283cell proliferationTAS8063729 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0045211postsynaptic membraneIEASynap, Neurotransmitter (GO term level: 5)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0005886plasma membraneTAS3272174 
GO:0005887integral to plasma membraneTAS3272174 
GO:0030054cell junctionIEA-
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CALCIUM_SIGNALING_PATHWAY 178134All SZGR genes in this pathway
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK 205136All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS 305177All SZGR genes in this pathway
REACTOME_AMINE_LIGAND_BINDING_RECEPTORS 3833All SZGR genes in this pathway
REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS 184116All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_UP 276165All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_UP 341197All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_DN 357212All SZGR genes in this pathway
KAYO_AGING_MUSCLE_UP 244165All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_DN 448282All SZGR genes in this pathway


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