Gene Page: U2AF2

Summary
GeneID  11338
Symbol  U2AF2
Synonyms  U2AF65
Description  U2 small nuclear RNA auxiliary factor 2
See related  HGNC:23156|MIM:191318|Ensembl:ENSG00000063244|HPRD:01872|
Locus tag  -
Gene type  protein-coding
Map location  19q13.42
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0583 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003723RNA bindingIEA-
GO:0005515protein bindingIPI9447963 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000398nuclear mRNA splicing, via spliceosomeEXP12226669 
GO:0000398nuclear mRNA splicing, via spliceosomeIC9731529 
GO:0008380RNA splicingIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005681spliceosomeIDA9731529 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BAT1D6S81E | DDX39B | UAP56HLA-B associated transcript 1U2AF65 interacts with UAP56.BIND9242493 
BEND7C10orf30 | FLJ40283 | MGC35247BEN domain containing 7Two-hybridBioGRID16189514 
C1orf190FLJ25163chromosome 1 open reading frame 190Two-hybridBioGRID16189514 
CHIC2BTL | MGC21173cysteine-rich hydrophobic domain 2Two-hybridBioGRID16189514 
DDX6FLJ36338 | HLR2 | P54 | RCKDEAD (Asp-Glu-Ala-Asp) box polypeptide 6-HPRD8816452 
DPPA2PESCRG1developmental pluripotency associated 2Two-hybridBioGRID16189514 
DVL2-dishevelled, dsh homolog 2 (Drosophila)Two-hybridBioGRID16189514 
KIAA0907RP11-336K24.1KIAA0907Two-hybridBioGRID16189514 
PRPF40AFBP-11 | FBP11 | FLAF1 | FLJ20585 | FNBP3 | HIP10 | HYPA | NY-REN-6PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)-HPRD15456888 
PUF60FIR | FLJ31379 | RoBPI | SIAHBP1poly-U binding splicing factor 60KDaAffinity Capture-MS
Two-hybrid		BioGRID16189514 |17353931 
RNPS1E5.1 | MGC117332RNA binding protein S1, serine-rich domainAffinity Capture-MSBioGRID17353931 
SF1D11S636 | ZFM1 | ZNF162splicing factor 1-HPRD,BioGRID9150140 |9512519 
U2AF65 interacts with an unspecified isoform of SF1 (mBBP).BIND9512519 
SF3A2PRP11 | PRPF11 | SAP62 | SF3a66splicing factor 3a, subunit 2, 66kDaAffinity Capture-MSBioGRID12234937 
SF3B1PRP10 | PRPF10 | SAP155 | SF3b155splicing factor 3b, subunit 1, 155kDaSAP155 interacts with U2AF65.BIND9671485 
SFRS1ASF | MGC5228 | SF2 | SF2p33 | SRp30asplicing factor, arginine/serine-rich 1Two-hybridBioGRID16189514 
SFRS11DKFZp686M13204 | dJ677H15.2 | p54splicing factor, arginine/serine-rich 11-HPRD,BioGRID8816452 
SFRS2IPCASP11 | SIP1 | SRRP129splicing factor, arginine/serine-rich 2, interacting protein-HPRD,BioGRID9447963 
SIP1GEMIN2 | SIP1-deltasurvival of motor neuron protein interacting protein 1-HPRD9447963 
SRPK1SFRSK1SFRS protein kinase 1-HPRD9472028 
SRPK2FLJ36101 | SFRSK2SFRS protein kinase 2Biochemical Activity
Two-hybrid		BioGRID9472028 |16189514 
TCERG1CA150 | MGC133200 | TAF2Stranscription elongation regulator 1-HPRD,BioGRID15456888 
THAP1FLJ10477 | MGC33014THAP domain containing, apoptosis associated protein 1Two-hybridBioGRID16189514 
U2AF1DKFZp313J1712 | FP793 | RN | RNU2AF1 | U2AF35 | U2AFBPU2 small nuclear RNA auxiliary factor 1-HPRD,BioGRID1388271 
hU2AF(65) and hU2AF(35) interact to form the U2AF splice factor heterodimer.BIND9528748 
WT1GUD | WAGR | WIT-2 | WT33Wilms tumor 1-HPRD,BioGRID9784496 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_SPLICEOSOME 12872All SZGR genes in this pathway
REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA 14077All SZGR genes in this pathway
REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM 5434All SZGR genes in this pathway
REACTOME_RNA_POL_II_TRANSCRIPTION 10554All SZGR genes in this pathway
REACTOME_MRNA_PROCESSING 16186All SZGR genes in this pathway
REACTOME_MRNA_SPLICING 11158All SZGR genes in this pathway
REACTOME_TRANSCRIPTION 210127All SZGR genes in this pathway
REACTOME_MRNA_3_END_PROCESSING 3518All SZGR genes in this pathway
REACTOME_CLEAVAGE_OF_GROWING_TRANSCRIPT_IN_THE_TERMINATION_REGION_ 4422All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN 335193All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
XU_AKT1_TARGETS_6HR 2718All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_UP 309199All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
SUNG_METASTASIS_STROMA_UP 11070All SZGR genes in this pathway
MORI_EMU_MYC_LYMPHOMA_BY_ONSET_TIME_UP 11069All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN 309206All SZGR genes in this pathway
ASTIER_INTEGRIN_SIGNALING 5944All SZGR genes in this pathway
PAL_PRMT5_TARGETS_UP 203135All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
JACKSON_DNMT1_TARGETS_DN 2521All SZGR genes in this pathway
LEE_AGING_MUSCLE_UP 4533All SZGR genes in this pathway
AMUNDSON_POOR_SURVIVAL_AFTER_GAMMA_RADIATION_8G 9562All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING 510309All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_UP 298174All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_LATE_RECURRENCE_DN 6948All SZGR genes in this pathway
YAGI_AML_WITH_T_8_21_TRANSLOCATION 368247All SZGR genes in this pathway
KASLER_HDAC7_TARGETS_1_UP 194133All SZGR genes in this pathway
HOLLEMAN_PREDNISOLONE_RESISTANCE_ALL_UP 1915All SZGR genes in this pathway


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