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| GeneID |
1137
|
| Symbol |
CHRNA4
|
| Synonyms |
BFNC|EBN|EBN1|FLJ95812|NACHR|NACHRA4|NACRA4
|
| Description |
cholinergic receptor, nicotinic, alpha 4 |
| See related |
HGNC:1958|MIM:118504|Ensembl:ENSG00000101204|HPRD:00333| |
| Locus tag |
- |
| Gene type |
protein-coding |
| Map location |
20q13.2-q13.3 |
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| Gene set name |
Method of gene set |
Evidence |
Info |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia] | Click to show detail | | GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 7 | |
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| General Gene Expression (microarray) ? |
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| Gene Expression in Brain Regions (new) |
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| Top co-expressed genes in Brain Regions (new) |
|
| Gene | Pearson's Correlation | Spearman's Correlation | | |
| Top 10 positively co-expressed genes |
| AC233723.1 | 0.84 | 0.87 | | |
| SYT5 | 0.76 | 0.76 | | |
| CES2 | 0.74 | 0.78 | | |
| PRRT2 | 0.73 | 0.77 | | |
| CCRK | 0.72 | 0.77 | | |
| PDZD4 | 0.72 | 0.77 | | |
| C11orf81 | 0.71 | 0.74 | | |
| DUSP8 | 0.71 | 0.75 | | |
| NUMBL | 0.70 | 0.75 | | |
| KATNB1 | 0.70 | 0.74 | | |
Top 10 negatively co-expressed genes | | AF347015.21 | -0.55 | -0.52 | | |
| MT-CO2 | -0.54 | -0.50 | | |
| AF347015.31 | -0.53 | -0.49 | | |
| AF347015.8 | -0.52 | -0.48 | | |
| MT-CYB | -0.52 | -0.47 | | |
| AF347015.26 | -0.51 | -0.46 | | |
| AF347015.27 | -0.51 | -0.48 | | |
| AF347015.2 | -0.51 | -0.45 | | |
| AF347015.33 | -0.51 | -0.45 | | |
| AL139819.3 | -0.50 | -0.53 | | |
|
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|
| GO:0030594 | neurotransmitter receptor activity | IEA | Neurotransmitter (GO term level: 5) | - |
| GO:0015464 | acetylcholine receptor activity | IDA | Neurotransmitter (GO term level: 6) | 8906617 |
| GO:0004889 | nicotinic acetylcholine-activated cation-selective channel activity | IDA | | 8906617 |
| GO:0005515 | protein binding | IEA | | - |
| GO:0005216 | ion channel activity | IEA | | - |
| GO:0005230 | extracellular ligand-gated ion channel activity | IEA | | - |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
|---|
| GO:0060080 | regulation of inhibitory postsynaptic membrane potential | ISS | neuron, Synap (GO term level: 10) | - |
| GO:0007271 | synaptic transmission, cholinergic | ISS | neuron, Cholinergic, Synap, Neurotransmitter (GO term level: 7) | - |
| GO:0014059 | regulation of dopamine secretion | ISS | dopamine (GO term level: 10) | - |
| GO:0001666 | response to hypoxia | IDA | | 12189247 |
| GO:0001508 | regulation of action potential | ISS | | - |
| GO:0006281 | DNA repair | IMP | | 16332175 |
| GO:0007165 | signal transduction | IDA | | 8906617 |
| GO:0007626 | locomotory behavior | IEA | | - |
| GO:0006816 | calcium ion transport | ISS | | - |
| GO:0006811 | ion transport | IEA | | - |
| GO:0006811 | ion transport | NAS | | 8906617 |
| GO:0006979 | response to oxidative stress | IMP | | 16332175 |
| GO:0042113 | B cell activation | ISS | | - |
| GO:0019233 | sensory perception of pain | ISS | | - |
| GO:0035095 | behavioral response to nicotine | IMP | | 17955458 |
| GO:0050890 | cognition | IMP | | 14623738 |
| GO:0051899 | membrane depolarization | ISS | | - |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
|---|
| GO:0005892 | nicotinic acetylcholine-gated receptor-channel complex | IDA | Neurotransmitter (GO term level: 9) | 8906617 |
| GO:0045211 | postsynaptic membrane | IEA | Synap, Neurotransmitter (GO term level: 5) | - |
| GO:0045202 | synapse | IEA | neuron, Synap, Neurotransmitter, Glial (GO term level: 2) | - |
| GO:0005624 | membrane fraction | ISS | | - |
| GO:0016021 | integral to membrane | IEA | | - |
| GO:0016021 | integral to membrane | NAS | | 8906617 |
| GO:0009897 | external side of plasma membrane | ISS | | - |
| GO:0005886 | plasma membrane | ISS | | - |
| GO:0030054 | cell junction | IEA | | - |
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