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| GeneID |
1143
|
| Symbol |
CHRNB4
|
| Synonyms |
-
|
| Description |
cholinergic receptor, nicotinic, beta 4 |
| See related |
HGNC:1964|MIM:118509|Ensembl:ENSG00000117971|HPRD:00337| |
| Locus tag |
- |
| Gene type |
protein-coding |
| Map location |
15q24 |
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| Gene set name |
Method of gene set |
Evidence |
Info |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia] | Click to show detail | | GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 7 | |
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| General Gene Expression (microarray) ? |
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| Gene Expression in Brain Regions (new) |
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| Top co-expressed genes in Brain Regions (new) |
|
| Gene | Pearson's Correlation | Spearman's Correlation | | |
| Top 10 positively co-expressed genes |
| PC | 0.79 | 0.81 | | |
| NR1H2 | 0.79 | 0.80 | | |
| THOP1 | 0.72 | 0.72 | | |
| NDUFAF3 | 0.70 | 0.73 | | |
| PNPLA2 | 0.70 | 0.65 | | |
| NAT8L | 0.70 | 0.72 | | |
| JOSD2 | 0.70 | 0.76 | | |
| GHDC | 0.70 | 0.67 | | |
| PDK2 | 0.70 | 0.74 | | |
| SPHK2 | 0.68 | 0.71 | | |
Top 10 negatively co-expressed genes | | SCN9A | -0.42 | -0.30 | | |
| C17orf57 | -0.41 | -0.34 | | |
| AC109829.1 | -0.40 | -0.36 | | |
| CCDC148 | -0.39 | -0.40 | | |
| AC073995.1 | -0.39 | -0.37 | | |
| GNRHR | -0.38 | -0.32 | | |
| AC087071.1 | -0.38 | -0.30 | | |
| NOX1 | -0.37 | -0.33 | | |
| ANKRD36B | -0.37 | -0.35 | | |
| CCDC122 | -0.36 | -0.29 | | |
|
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|
| GO:0015464 | acetylcholine receptor activity | IDA | Neurotransmitter (GO term level: 6) | 8906617 |
| GO:0004889 | nicotinic acetylcholine-activated cation-selective channel activity | TAS | | 8906617 |11742001 |
| GO:0005216 | ion channel activity | IEA | | - |
| GO:0005230 | extracellular ligand-gated ion channel activity | IEA | | - |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
|---|
| GO:0060084 | synaptic transmission involved in micturition | IMP | neuron, Synap (GO term level: 8) | 11450844 |
| GO:0046928 | regulation of neurotransmitter secretion | NAS | Synap, Neurotransmitter (GO term level: 9) | 11742001 |
| GO:0007271 | synaptic transmission, cholinergic | TAS | neuron, Cholinergic, Synap, Neurotransmitter (GO term level: 7) | 1330682 |
| GO:0001508 | regulation of action potential | IEA | | - |
| GO:0007165 | signal transduction | IDA | | 8906617 |
| GO:0007626 | locomotory behavior | IEA | | - |
| GO:0006811 | ion transport | TAS | | 8906617 |
| GO:0006940 | regulation of smooth muscle contraction | IEA | | - |
| GO:0035095 | behavioral response to nicotine | IEA | | - |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
|---|
| GO:0005892 | nicotinic acetylcholine-gated receptor-channel complex | IDA | Neurotransmitter (GO term level: 9) | 8906617 |
| GO:0005892 | nicotinic acetylcholine-gated receptor-channel complex | TAS | Neurotransmitter (GO term level: 9) | 11742001 |
| GO:0045211 | postsynaptic membrane | IEA | Synap, Neurotransmitter (GO term level: 5) | - |
| GO:0045202 | synapse | IEA | neuron, Synap, Neurotransmitter, Glial (GO term level: 2) | - |
| GO:0005886 | plasma membrane | IEA | | - |
| GO:0030054 | cell junction | IEA | | - |
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