Gene Page: CISH

Summary
GeneID  1154
Symbol  CISH
Synonyms  CIS|CIS-1|G18|SOCS
Description  cytokine inducible SH2-containing protein
See related  HGNC:1984|MIM:602441|Ensembl:ENSG00000114737|HPRD:03897|
Locus tag  -
Gene type  protein-coding
Map location  3p21.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0305 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PBK0.800.59
OIP50.800.54
CKS20.800.55
MAGOH0.800.64
KIAA01010.790.53
HMGB20.790.54
CDC20.790.54
FBXO50.790.51
MND10.780.57
SHCBP10.780.52
Top 10 negatively co-expressed genes
PTH1R-0.40-0.52
TINAGL1-0.38-0.52
MGLL-0.37-0.38
HLA-F-0.37-0.43
ATP10A-0.36-0.47
TNFSF12-0.36-0.44
ZNF385A-0.36-0.49
ALDOC-0.36-0.44
CA4-0.35-0.44
AF347015.33-0.35-0.47
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003674molecular_functionND-
GO:0005515protein bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001558regulation of cell growthNAS9465889 
GO:0007205activation of protein kinase C activityIEA-
GO:0009968negative regulation of signal transductionIEA-
GO:0006511ubiquitin-dependent protein catabolic processIEA-
GO:0007242intracellular signaling cascadeNAS10902923 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005575cellular_componentND-
GO:0005886plasma membraneIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
EPORMGC138358erythropoietin receptor-HPRD9774439 
-HPRD,BioGRID7796808 
GHRGHBPgrowth hormone receptorAffinity Capture-Western
Reconstituted Complex
BioGRID10585430 
IL2RBCD122 | P70-75interleukin 2 receptor, beta-HPRD,BioGRID10514520 
IL3RACD123 | IL3R | IL3RAY | IL3RX | IL3RY | MGC34174 | hIL-3Rainterleukin 3 receptor, alpha (low affinity)-HPRD,BioGRID7796808 
MAPKSP1MAP2K1IP1 | MAPBP | MP1MAPK scaffold protein 1-HPRD10517496 
 


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