Gene Page: SERPINA3

Summary
GeneID  12
Symbol  SERPINA3
Synonyms  AACT|ACT|GIG24|GIG25|MGC88254
Description  serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
See related  HGNC:16|MIM:107280|Ensembl:ENSG00000196136|HPRD:00120|
Locus tag  -
Gene type  protein-coding
Map location  14q32.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 1.866 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0078 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
NUDT180.540.43
SULT1A10.540.43
SHISA40.530.47
C6orf10.530.51
C12orf620.520.50
EGFL70.520.46
NDUFA70.520.45
C11orf590.520.44
ISOC20.520.53
LRRC290.520.47
Top 10 negatively co-expressed genes
ZNF326-0.38-0.41
SFRS12-0.38-0.41
THOC2-0.37-0.40
PRPF38B-0.36-0.42
RBM25-0.35-0.41
MAP4K4-0.35-0.36
ZC3H13-0.35-0.35
HNRNPH3-0.35-0.40
PHF3-0.35-0.37
EIF3A-0.35-0.37
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003677DNA bindingIC9880565 
GO:0003677DNA bindingTAS14668352 
GO:0005515protein bindingIPI12709365 |14668352 |14687906 
GO:0030569chymotrypsin inhibitor activityNAS9880565 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006954inflammatory responseNAS12475184 
GO:0006953acute-phase responseIEA-
GO:0019216regulation of lipid metabolic processNAS11835318 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionNAS9880565 |14718574 
GO:0005622intracellularNAS9880565 
GO:0005634nucleusTAS14668352 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
APPAAA | ABETA | ABPP | AD1 | APPI | CTFgamma | CVAP | PN2amyloid beta (A4) precursor protein-HPRD2190106|10048303 
CMA1CYH | MCT1 | MGC119890 | MGC119891 | chymasechymase 1, mast cell-HPRD8226889 
CTRB1CTRB | FLJ42412 | MGC88037chymotrypsinogen B1-HPRD2435303 
CTRLCTRL1 | MGC70821chymotrypsin-like-HPRD8267879 
CTSGCG | MGC23078cathepsin GAlpha-1 ACT interacts with and inhibits cathepsin G.BIND15131125 
-HPRD8849841 |9698370 
|10512690 
DNAJC1DNAJL1 | ERdj1 | HTJ1 | MGC131954 | MTJ1DnaJ (Hsp40) homolog, subfamily C, member 1-HPRD,BioGRID14668352 
ELA1-elastase 1, pancreatic-HPRD2456771 |7759598 
ELA2GE | HLE | HNE | NE | PMN-Eelastase 2, neutrophil-HPRD,BioGRID8011628 |8718849 
ERBB2CD340 | HER-2 | HER-2/neu | HER2 | NEU | NGL | TKR1v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)-HPRD10829039 
F5FVL | PCCFcoagulation factor V (proaccelerin, labile factor)-HPRD8216224 
KLK2KLK2A2 | MGC12201 | hK2kallikrein-related peptidase 2-HPRD,BioGRID9042371 |9428387 
KLK3APS | KLK2A1 | PSA | hK3kallikrein-related peptidase 3-HPRD8732755 |9261179 
|10759471 |11317942 
|11735417 
LRP1A2MR | APOER | APR | CD91 | FLJ16451 | IGFBP3R | LRP | MGC88725 | TGFBR5low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)LRP interacts with alpha-1-ACT.BIND15131125 
MST1D3F15S2 | DNF15S2 | HGFL | MSP | NF15S2macrophage stimulating 1 (hepatocyte growth factor-like)-HPRD11274154 
POLA1DKFZp686K1672 | POLA | p180polymerase (DNA directed), alpha 1, catalytic subunit-HPRD3490907 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
FOURNIER_ACINAR_DEVELOPMENT_LATE_UP 116All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_WITH_LMP1_DN 17582All SZGR genes in this pathway
LIU_CMYB_TARGETS_UP 165106All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_BASAL_VS_MESENCHYMAL_UP 12145All SZGR genes in this pathway
SABATES_COLORECTAL_ADENOMA_UP 14175All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
OUELLET_CULTURED_OVARIAN_CANCER_INVASIVE_VS_LMP_DN 3520All SZGR genes in this pathway
WONG_ENDMETRIUM_CANCER_UP 2517All SZGR genes in this pathway
WONG_ENDOMETRIAL_CANCER_LATE 105All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2B 392251All SZGR genes in this pathway
AIYAR_COBRA1_TARGETS_UP 3925All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_DN 193112All SZGR genes in this pathway
RICKMAN_HEAD_AND_NECK_CANCER_C 11347All SZGR genes in this pathway
COLIN_PILOCYTIC_ASTROCYTOMA_VS_GLIOBLASTOMA_UP 3532All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_DN 464276All SZGR genes in this pathway
CHESLER_BRAIN_QTL_CIS 7551All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
LEE_LIVER_CANCER_MYC_DN 6340All SZGR genes in this pathway
HSIAO_LIVER_SPECIFIC_GENES 244154All SZGR genes in this pathway
KAAB_FAILED_HEART_ATRIUM_DN 14199All SZGR genes in this pathway
RUAN_RESPONSE_TO_TNF_UP 1210All SZGR genes in this pathway
KAYO_AGING_MUSCLE_UP 244165All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
RUAN_RESPONSE_TO_TNF_TROGLITAZONE_UP 1711All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_DN 245144All SZGR genes in this pathway
KEEN_RESPONSE_TO_ROSIGLITAZONE_DN 10668All SZGR genes in this pathway
KAAB_FAILED_HEART_VENTRICLE_DN 4128All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_UP 253147All SZGR genes in this pathway
BURTON_ADIPOGENESIS_PEAK_AT_16HR 4024All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_4 307185All SZGR genes in this pathway
RIGGINS_TAMOXIFEN_RESISTANCE_DN 220147All SZGR genes in this pathway
SARRIO_EPITHELIAL_MESENCHYMAL_TRANSITION_DN 154101All SZGR genes in this pathway
MCCABE_BOUND_BY_HOXC6 469239All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_UP 172109All SZGR genes in this pathway
BOQUEST_STEM_CELL_UP 260174All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_UP 425298All SZGR genes in this pathway
ALONSO_METASTASIS_EMT_UP 3624All SZGR genes in this pathway
ALONSO_METASTASIS_UP 198128All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
LIU_VAV3_PROSTATE_CARCINOGENESIS_UP 8961All SZGR genes in this pathway
POOLA_INVASIVE_BREAST_CANCER_DN 13483All SZGR genes in this pathway
SCHOEN_NFKB_SIGNALING 3426All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S3 266180All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_6 2920All SZGR genes in this pathway
PECE_MAMMARY_STEM_CELL_UP 14675All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_UP 289184All SZGR genes in this pathway
NABA_ECM_REGULATORS 238125All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway


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