Gene Page: ADORA2A

Summary
GeneID  135
Symbol  ADORA2A
Synonyms  ADORA2|RDC8|hA2aR
Description  adenosine A2a receptor
See related  HGNC:263|MIM:102776|Ensembl:ENSG00000128271|HPRD:00043|
Locus tag  -
Gene type  protein-coding
Map location  22q11.23
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.031 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 4 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.1128 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0001609adenosine receptor activity, G-protein coupledIEA-
GO:0004872receptor activityIEA-
GO:0016519gastric inhibitory peptide receptor activityNAS8522976 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007417central nervous system developmentTASBrain (GO term level: 6)10945659 
GO:0032230positive regulation of synaptic transmission, GABAergicIEAneuron, GABA, Synap, Neurotransmitter (GO term level: 10)-
GO:0001963synaptic transmission, dopaminergicIEAneuron, Synap, Neurotransmitter, dopamine (GO term level: 8)-
GO:0006836neurotransmitter transportNASneuron, Neurotransmitter (GO term level: 5)8522976 
GO:0001975response to amphetamineIEA-
GO:0001973adenosine receptor signaling pathwayIEA-
GO:0007190activation of adenylate cyclase activityEXP16805430 
GO:0007189G-protein signaling, adenylate cyclase activating pathwayIEA-
GO:0007188G-protein signaling, coupled to cAMP nucleotide second messengerTAS10899090 
GO:0007186G-protein coupled receptor protein signaling pathwayIEA-
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayEXP16939974 
GO:0007267cell-cell signalingTAS7818494 
GO:0006171cAMP biosynthetic processTAS10899090 
GO:0006968cellular defense responseTAS10051547 
GO:0007165signal transductionIEA-
GO:0008015blood circulationTAS9262401 
GO:0007626locomotory behaviorIEA-
GO:0007600sensory perceptionTAS9262401 
GO:0007596blood coagulationTAS10899090 
GO:0006954inflammatory responseTAS8360491 
GO:0006915apoptosisTAS7818494 
GO:0006909phagocytosisTAS8360491 
GO:0042755eating behaviorIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005624membrane fractionIEA-
GO:0005624membrane fractionTAS10051547 
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneTAS8794889 |10051547 
GO:0005887integral to plasma membraneTAS8794889 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ADA-adenosine deaminase-HPRD,BioGRID11125033 
ADORA2AADORA2 | RDC8 | hA2aRadenosine A2a receptorFRETBioGRID12804599 
DRD2D2DR | D2Rdopamine receptor D2-HPRD,BioGRID12804599 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CALCIUM_SIGNALING_PATHWAY 178134All SZGR genes in this pathway
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 11581All SZGR genes in this pathway
PID_HIF2PATHWAY 3429All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 137105All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS 305177All SZGR genes in this pathway
REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS 168All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_G_ALPHA_S_SIGNALLING_EVENTS 12182All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_5 14789All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2B 392251All SZGR genes in this pathway
KOYAMA_SEMA3B_TARGETS_DN 411249All SZGR genes in this pathway
ROZANOV_MMP14_TARGETS_UP 266171All SZGR genes in this pathway
FAELT_B_CLL_WITH_VH_REARRANGEMENTS_UP 4834All SZGR genes in this pathway
MCCLUNG_DELTA_FOSB_TARGETS_8WK 4738All SZGR genes in this pathway
MCCLUNG_COCAINE_REWARD_5D 7962All SZGR genes in this pathway
ZHANG_ANTIVIRAL_RESPONSE_TO_RIBAVIRIN_DN 5132All SZGR genes in this pathway
SAFFORD_T_LYMPHOCYTE_ANERGY 8754All SZGR genes in this pathway
MAHAJAN_RESPONSE_TO_IL1A_UP 8152All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_UP 15692All SZGR genes in this pathway
YAUCH_HEDGEHOG_SIGNALING_PARACRINE_DN 264159All SZGR genes in this pathway
LINDSTEDT_DENDRITIC_CELL_MATURATION_B 5336All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED 536296All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
MIKKELSEN_MCV6_HCP_WITH_H3K27ME3 435318All SZGR genes in this pathway
WIERENGA_STAT5A_TARGETS_DN 213127All SZGR genes in this pathway
CERIBELLI_GENES_INACTIVE_AND_BOUND_BY_NFY 4527All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-214537543m8hsa-miR-214brainACAGCAGGCACAGACAGGCAG
miR-34b786792m8hsa-miR-34bUAGGCAGUGUCAUUAGCUGAUUG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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