Gene Page: ATF6B

Summary
GeneID  1388
Symbol  ATF6B
Synonyms  CREB-RP|CREBL1|FLJ10066|G13
Description  activating transcription factor 6 beta
See related  HGNC:2349|MIM:600984|Ensembl:ENSG00000213676|HPRD:02992|
Locus tag  DADB-220I18.4
Gene type  protein-coding
Map location  6p21.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
LRRC240.910.91
COMTD10.890.89
GNB20.890.91
C19orf220.890.92
FBL0.880.92
NFKBIE0.880.88
LRFN40.880.92
HTRA20.870.87
RTN20.870.88
AC009133.10.870.90
Top 10 negatively co-expressed genes
AF347015.27-0.68-0.75
AF347015.33-0.67-0.75
AF347015.8-0.66-0.75
MT-CO2-0.66-0.72
MT-CYB-0.66-0.74
AF347015.31-0.65-0.72
AF347015.15-0.65-0.74
AF347015.26-0.64-0.75
AF347015.2-0.64-0.73
MT-ATP8-0.59-0.76
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityTAS8586413 
GO:0043565sequence-specific DNA bindingIEA-
GO:0046983protein dimerization activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006350transcriptionTAS8586413 
GO:0006986response to unfolded proteinIEA-
GO:0007165signal transductionTAS8586413 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005789endoplasmic reticulum membraneIEA-
GO:0005622intracellularIDA8870652 
GO:0005634nucleusTAS8586413 
GO:0005783endoplasmic reticulumIEA-
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATF6ATF6Aactivating transcription factor 6Two-hybridBioGRID11158310 
MBTPS1KIAA0091 | MGC138711 | MGC138712 | PCSK8 | S1P | SKI-1membrane-bound transcription factor peptidase, site 1-HPRD,BioGRID11163209 
MBTPS2FLJ32174 | S2Pmembrane-bound transcription factor peptidase, site 2-HPRD,BioGRID11163209 
NFYACBF-A | CBF-B | FLJ11236 | HAP2 | NF-YAnuclear transcription factor Y, alphaTwo-hybridBioGRID11158310 
NFYCCBF-C | CBFC | DKFZp667G242 | FLJ45775 | H1TF2A | HAP5 | HSM | NF-YCnuclear transcription factor Y, gamma-HPRD,BioGRID11158310 
PHOX2AARIX | CFEOM2 | FEOM2 | MGC52227 | NCAM2 | PMX2Apaired-like homeobox 2a-HPRD10644760 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
LIU_PROSTATE_CANCER_UP 9657All SZGR genes in this pathway
LIU_SOX4_TARGETS_UP 13794All SZGR genes in this pathway
BOGNI_TREATMENT_RELATED_MYELOID_LEUKEMIA_UP 3019All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
YAGI_AML_SURVIVAL 12987All SZGR genes in this pathway
KAYO_CALORIE_RESTRICTION_MUSCLE_DN 8759All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR 681420All SZGR genes in this pathway
SU_PLACENTA 3018All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_DN 668419All SZGR genes in this pathway
SAKAI_CHRONIC_HEPATITIS_VS_LIVER_CANCER_UP 8363All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_14 14386All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-93.hd/291-3p/294/295/302/372/373/5201281351A,m8hsa-miR-93brainAAAGUGCUGUUCGUGCAGGUAG
hsa-miR-302aUAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302bUAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302cUAAGUGCUUCCAUGUUUCAGUGG
hsa-miR-302dUAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520eAAAGUGCUUCCUUUUUGAGGG
hsa-miR-520aAAAGUGCUUCCCUUUGGACUGU
hsa-miR-520bAAAGUGCUUCCUUUUAGAGGG
hsa-miR-520cAAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520dAAAGUGCUUCUCUUUGGUGGGUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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