Gene Page: CRP

Summary
GeneID  1401
Symbol  CRP
Synonyms  MGC149895|MGC88244|PTX1
Description  C-reactive protein, pentraxin-related
See related  HGNC:2367|MIM:123260|Ensembl:ENSG00000132693|HPRD:00422|
Locus tag  -
Gene type  protein-coding
Map location  1q21-q23
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0235 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00814 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
AP000907.50.970.99
DBNDD20.910.93
CMTM50.900.94
MAL0.900.93
RTKN0.890.93
APOD0.890.94
SEPT40.880.90
RNASE10.880.92
PLA2G160.880.93
NINJ20.870.92
Top 10 negatively co-expressed genes
NKIRAS2-0.65-0.76
CRMP1-0.63-0.74
FGD1-0.61-0.73
PCDHB18-0.61-0.76
PURG-0.61-0.72
KIAA1949-0.61-0.74
HMGB3-0.61-0.78
FARP1-0.61-0.72
ZNF599-0.61-0.74
ZNF821-0.61-0.73
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005509calcium ion bindingIEA-
GO:0005515protein bindingIPI17785206 
GO:0033265choline bindingTAS2477488 
GO:0051637Gram-positive bacterial cell surface bindingTAS2477488 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006954inflammatory responseTAS10408362 
GO:0006953acute-phase responseIEA-
GO:0008228opsonizationTAS2477488 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionNAS14718574 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
APCSMGC88159 | PTX2 | SAPamyloid P component, serum-HPRD,BioGRID1477104|8144569 
C1QA-complement component 1, q subcomponent, A chainReconstituted ComplexBioGRID10490997 
CFHARMD4 | ARMS1 | CFHL3 | FH | FHL1 | HF | HF1 | HF2 | HUS | MGC88246complement factor H-HPRD,BioGRID10490997 
CRPMGC149895 | MGC88244 | PTX1C-reactive protein, pentraxin-related-HPRD12037301 
FCGR1ACD64 | CD64A | FCRI | FLJ18345 | IGFR1Fc fragment of IgG, high affinity Ia, receptor (CD64)-HPRD,BioGRID12471137 
FCGR2ACD32 | CD32A | CDw32 | FCG2 | FCGR2 | FCGR2A1 | FcGR | IGFR2 | MGC23887 | MGC30032Fc fragment of IgG, low affinity IIa, receptor (CD32)-HPRD,BioGRID10675363 
FCGR2BCD32 | CD32B | FCG2 | FCGR2 | IGFR2Fc fragment of IgG, low affinity IIb, receptor (CD32)-HPRD,BioGRID12471137 
FN1CIG | DKFZp686F10164 | DKFZp686H0342 | DKFZp686I1370 | DKFZp686O13149 | ED-B | FINC | FN | FNZ | GFND | GFND2 | LETS | MSFfibronectin 1-HPRD,BioGRID6693419 
GP6GPIV | GPVI | MGC138168glycoprotein VI (platelet)-HPRD11027634 
SNRNP70RNPU1Z | RPU1 | SNRP70 | U170K | U1AP | U1RNPsmall nuclear ribonucleoprotein 70kDa (U1)-HPRD,BioGRID2477447 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_IL6_7_PATHWAY 4740All SZGR genes in this pathway
REACTOME_INNATE_IMMUNE_SYSTEM 279178All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_COMPLEMENT_CASCADE 3222All SZGR genes in this pathway
REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS 105All SZGR genes in this pathway
REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT 1610All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_UP 276165All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_2_UP 13983All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_UP 341197All SZGR genes in this pathway
HSIAO_LIVER_SPECIFIC_GENES 244154All SZGR genes in this pathway
SU_LIVER 5532All SZGR genes in this pathway
TUOMISTO_TUMOR_SUPPRESSION_BY_COL13A1_DN 1711All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_DN 540340All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
TAVAZOIE_METASTASIS 10868All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_DN 170105All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_DN 267160All SZGR genes in this pathway
CAIRO_LIVER_DEVELOPMENT_DN 222141All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway
MAEKAWA_ATF2_TARGETS 2419All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_DN 553343All SZGR genes in this pathway
SERVITJA_LIVER_HNF1A_TARGETS_DN 157105All SZGR genes in this pathway


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