Gene Page: ADRA1A

Summary
GeneID  148
Symbol  ADRA1A
Synonyms  ADRA1C|ADRA1L1|ALPHA1AAR
Description  adrenergic, alpha-1A-, receptor
See related  HGNC:277|MIM:104221|Ensembl:ENSG00000120907|HPRD:00081|
Locus tag  -
Gene type  protein-coding
Map location  8p21-p11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
GSMA_Igenome scan meta-analysisPsr: 0.031 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.03086 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.00057 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
C12orf340.720.69
SOX80.660.67
PLEKHG30.650.65
KCNJ20.650.48
SH3RF20.650.58
DACT20.620.37
SLC35D30.610.34
MME0.600.24
PRIMA10.600.66
GPR1490.590.37
Top 10 negatively co-expressed genes
GPM6A-0.32-0.44
GPR22-0.31-0.43
EMID1-0.31-0.41
EMX1-0.31-0.42
MPPED1-0.31-0.44
DPP4-0.30-0.42
ZNF238-0.30-0.39
SNX7-0.30-0.44
ULBP2-0.29-0.38
NEUROD6-0.29-0.49
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0004937alpha1-adrenergic receptor activityNAS9490024 
GO:0004937alpha1-adrenergic receptor activityTAS7737411 
GO:0004935adrenoceptor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007186G-protein coupled receptor protein signaling pathwayTAS10860850 
GO:0007267cell-cell signalingTAS8396931 
GO:0007243protein kinase cascadeTAS10671514 
GO:0007165signal transductionTAS8396931 
GO:0008285negative regulation of cell proliferationTAS10860850 
GO:0006939smooth muscle contractionTAS8183249 
GO:0006915apoptosisTAS10671514 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS8396931 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BMP1FLJ44432 | PCOLC | PCP | TLD | pCP-2bone morphogenetic protein 1The carboxy-terminus of alpha-1A-AR interacts with BMP-1.BIND15525470 
PPP1R9BFLJ30345 | PPP1R6 | PPP1R9 | SPINO | Spnprotein phosphatase 1, regulatory (inhibitor) subunit 9B-HPRD11154706 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CALCIUM_SIGNALING_PATHWAY 178134All SZGR genes in this pathway
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 11581All SZGR genes in this pathway
REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK 205136All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS 305177All SZGR genes in this pathway
REACTOME_AMINE_LIGAND_BINDING_RECEPTORS 3833All SZGR genes in this pathway
REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS 184116All SZGR genes in this pathway
REACTOME_G_ALPHA1213_SIGNALLING_EVENTS 7456All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
HATADA_METHYLATED_IN_LUNG_CANCER_UP 390236All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
KAYO_AGING_MUSCLE_UP 244165All SZGR genes in this pathway
LEE_LIVER_CANCER 4929All SZGR genes in this pathway
LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP 7451All SZGR genes in this pathway
OUILLETTE_CLL_13Q14_DELETION_UP 7440All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING 510309All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_LATE_RECURRENCE_DN 6948All SZGR genes in this pathway
GYORFFY_MITOXANTRONE_RESISTANCE 5735All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3 590403All SZGR genes in this pathway


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