Gene Page: ADRA2B

Summary
GeneID  151
Symbol  ADRA2B
Synonyms  ADRA2L1|ADRA2RL1|ADRARL1|ALPHA2BAR
Description  adrenergic, alpha-2B-, receptor
See related  HGNC:282|MIM:104260|HPRD:00086|
Locus tag  -
Gene type  protein-coding
Map location  2p13-q13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0004 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
UNC93B30.680.68
CXCL160.660.71
PARP120.640.68
TNFRSF1A0.640.68
SLC15A30.630.69
HLA-E0.620.68
LGALS90.610.69
BAMBI0.600.64
FAH0.600.65
IRF10.600.65
Top 10 negatively co-expressed genes
RTF1-0.51-0.54
SRPK1-0.49-0.51
ANKRD12-0.49-0.55
TMEM57-0.48-0.49
ZNF714-0.48-0.51
MPP3-0.48-0.50
KIDINS220-0.48-0.47
STMN1-0.48-0.53
BZW2-0.48-0.53
ZNF91-0.48-0.51
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0004938alpha2-adrenergic receptor activityTAS2164221 
GO:0004935adrenoceptor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007186G-protein coupled receptor protein signaling pathwayTAS2164221 
GO:0007267cell-cell signalingTAS2164221 
GO:0007165signal transductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005886plasma membraneTAS2164221 
GO:0005887integral to plasma membraneTAS2164221 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
EIF2B1EIF-2B | EIF-2Balpha | EIF2B | EIF2BA | MGC117409 | MGC125868 | MGC125869eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa-HPRD,BioGRID9235896 
GNAI2GIP | GNAI2B | H_LUCA15.1 | H_LUCA16.1guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2-HPRD2169434 
PPP1R9BFLJ30345 | PPP1R6 | PPP1R9 | SPINO | Spnprotein phosphatase 1, regulatory (inhibitor) subunit 9BReconstituted ComplexBioGRID11154706 
YWHAZKCIP-1 | MGC111427 | MGC126532 | MGC138156tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide-HPRD10224112 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS 305177All SZGR genes in this pathway
REACTOME_AMINE_LIGAND_BINDING_RECEPTORS 3833All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_G_ALPHA_I_SIGNALLING_EVENTS 195114All SZGR genes in this pathway
REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS 4429All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION 3623All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 208138All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_CDC25_DN 153100All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_DN 357212All SZGR genes in this pathway
CHESLER_BRAIN_D6MIT150_QTL_TRANS 97All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3 142103All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_LATE_RECURRENCE_DN 6948All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SURVIVAL_DN 11376All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3 210148All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1399149201Ahsa-miR-139brainUCUACAGUGCACGUGUCU
miR-23854860m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-30-5p893899m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-3238548601Ahsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-329939945m8hsa-miR-329brainAACACACCUGGUUAACCUCUUU
miR-3308168221Ahsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
miR-3779419481A,m8hsa-miR-377AUCACACAAAGGCAACUUUUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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