Gene Page: ADRB1

Summary
GeneID  153
Symbol  ADRB1
Synonyms  ADRB1R|B1AR|BETA1AR|RHR
Description  adrenergic, beta-1-, receptor
See related  HGNC:285|MIM:109630|Ensembl:ENSG00000043591|HPRD:00181|
Locus tag  -
Gene type  protein-coding
Map location  10q24-q26
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0018 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
BAP10.900.87
BRSK10.890.85
SBF10.880.88
SEPT50.880.86
RANGAP10.880.87
AGAP30.880.85
SCYL10.880.84
RAB11FIP30.880.87
KATNB10.880.84
GIT10.870.86
Top 10 negatively co-expressed genes
AF347015.21-0.72-0.54
MT-CO2-0.65-0.48
AF347015.8-0.64-0.47
AF347015.31-0.64-0.49
AP002478.3-0.63-0.56
NOSTRIN-0.63-0.49
AF347015.18-0.62-0.44
GNG11-0.62-0.54
AL139819.3-0.62-0.56
MT-CYB-0.61-0.45
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0005515protein bindingIPI16316992 
GO:0004940beta1-adrenergic receptor activityIEA-
GO:0004940beta1-adrenergic receptor activityTAS10212248 
GO:0004935adrenoceptor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001996positive regulation of heart rate by epinephrine-norepinephrineIEA-
GO:0001997positive regulation of the force of heart contraction by epinephrine-norepinephrineIEA-
GO:0002024diet induced thermogenesisIEA-
GO:0002025vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressureIEA-
GO:0007190activation of adenylate cyclase activityTAS10212248 
GO:0007189G-protein signaling, adenylate cyclase activating pathwayIEA-
GO:0007186G-protein coupled receptor protein signaling pathwayIEA-
GO:0007165signal transductionIEA-
GO:0009409response to coldIEA-
GO:0040015negative regulation of multicellular organism growthIEA-
GO:0042596fear responseIEA-
GO:0050873brown fat cell differentiationIEA-
GO:0031649heat generationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005624membrane fractionIEA-
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneTAS10212248 
GO:0005887integral to plasma membraneTAS10212248 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ADRA2AADRA2 | ADRA2R | ADRAR | ALPHA2AAR | ZNF32adrenergic, alpha-2A-, receptorAlpha-2A-AR interacts with beta-1-AR.BIND12529373 
ARRB1ARB1 | ARR1arrestin, beta 1-HPRD,BioGRID10862778 
DLG4FLJ97752 | FLJ98574 | PSD95 | SAP90discs, large homolog 4 (Drosophila)-HPRD,BioGRID10995758 
GIPC1C19orf3 | GIPC | GLUT1CBP | Hs.6454 | IIP-1 | MGC15889 | MGC3774 | NIP | RGS19IP1 | SEMCAP | SYNECTIIN | SYNECTIN | TIP-2GIPC PDZ domain containing family, member 1Affinity Capture-Western
Two-hybrid		BioGRID12724327 
The carboxy terminus of beta-1-AR interacts with GIPC.BIND12724327 
GPRASP1GASP | GASP1 | KIAA0443G protein-coupled receptor associated sorting protein 1GASP-1 interacts with beta-1-AR.BIND15086532 
GPRASP2FLJ35662 | FLJ37327 | GASP2G protein-coupled receptor associated sorting protein 2GASP-2 interacts with beta-1-AR.BIND15086532 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2beta-1-AR interacts with Grb2.BIND9843378 
MAGI2ACVRIP1 | AIP1 | ARIP1 | MAGI-2 | SSCAMmembrane associated guanylate kinase, WW and PDZ domain containing 2-HPRD11526121 
SH3GL2CNSA2 | EEN-B1 | FLJ20276 | FLJ25015 | SH3D2A | SH3P4SH3-domain GRB2-like 2Beta-1-AR interacts with SH3p4. This interaction was modeled on a demonstrated interaction between human Beta-1-AR and rat or cow SH3p4.BIND10535961 
SH3GL3CNSA3 | EEN-2B-L3 | EEN-B2 | HsT19371 | SH3D2C | SH3P13SH3-domain GRB2-like 3Beta-1-AR interacts with SH3p13. This interaction was modeled on a demonstrated interaction between human Beta-1-AR and rat SH3p13.BIND10535961 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CALCIUM_SIGNALING_PATHWAY 178134All SZGR genes in this pathway
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
KEGG_ENDOCYTOSIS 183132All SZGR genes in this pathway
KEGG_GAP_JUNCTION 9068All SZGR genes in this pathway
KEGG_DILATED_CARDIOMYOPATHY 9268All SZGR genes in this pathway
ST_MYOCYTE_AD_PATHWAY 2725All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS 305177All SZGR genes in this pathway
REACTOME_AMINE_LIGAND_BINDING_RECEPTORS 3833All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_G_ALPHA_S_SIGNALLING_EVENTS 12182All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_3D_UP 182110All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_UP 15791All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_UP 194122All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_16D_UP 175108All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2A_UP 85All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_CD1_UP 4529All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_CD1_VS_CD2_UP 6647All SZGR genes in this pathway
XU_GH1_AUTOCRINE_TARGETS_UP 268157All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP 783442All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3 720440All SZGR genes in this pathway
WALLACE_PROSTATE_CANCER_RACE_DN 8842All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_DN 353226All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/987047111A,m8hsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-101112411311A,m8hsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-141/200a9439501A,m8hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-144112511311Ahsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-199809861Ahsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-25/32/92/363/367131313201A,m8hsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-30-5p5864m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-329122812341Ahsa-miR-329brainAACACACCUGGUUAACCUCUUU
miR-369-3p114211481Ahsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-374114211491A,m8hsa-miR-374UUAUAAUACAACCUGAUAAGUG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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