Gene Page: AP2B1

Summary
GeneID  163
Symbol  AP2B1
Synonyms  ADTB2|AP105B|AP2-BETA|CLAPB1|DKFZp781K0743
Description  adaptor-related protein complex 2, beta 1 subunit
See related  HGNC:563|MIM:601025|Ensembl:ENSG00000006125|HPRD:03015|
Locus tag  -
Gene type  protein-coding
Map location  17q11.2-q12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0263 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
MRPL40.880.87
WDR450.880.88
ANKRD390.880.85
PHKG20.870.87
SLC25A110.860.82
MRPL380.860.84
TRUB20.860.86
TMEM850.860.79
UQCRC10.860.83
ERI30.850.80
Top 10 negatively co-expressed genes
AF347015.18-0.56-0.42
MT-ATP8-0.52-0.39
AL139819.3-0.51-0.48
AF347015.26-0.50-0.34
AF347015.8-0.49-0.34
AC010300.1-0.48-0.49
AF347015.2-0.47-0.30
MT-CYB-0.46-0.33
AF347015.21-0.46-0.34
AF347015.15-0.45-0.31
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI12221107 
GO:0008565protein transporter activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006886intracellular protein transportIEA-
GO:0016192vesicle-mediated transportIEA-
GO:0050690regulation of defense response to virus by virusEXP16103193 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP2014052 |16103193 
GO:0030117membrane coatIEA-
GO:0005905coated pitIEA-
GO:0005886plasma membraneIEA-
GO:0030131clathrin adaptor complexIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AP1M1AP47 | CLAPM2 | CLTNM | MU-1Aadaptor-related protein complex 1, mu 1 subunitTwo-hybridBioGRID16189514 
AP1M2AP1-mu2 | HSMU1B | MU-1B | MU1B | mu2adaptor-related protein complex 1, mu 2 subunitAffinity Capture-Western
Two-hybrid		BioGRID16189514 
-HPRD12086608 
AP2A2ADTAB | CLAPA2 | HIP9 | HYPJadaptor-related protein complex 2, alpha 2 subunit-HPRD12086608 
AP2M1AP50 | CLAPM1 | mu2adaptor-related protein complex 2, mu 1 subunitTwo-hybridBioGRID16189514 
AP2S1AP17 | AP17-DELTA | CLAPS2adaptor-related protein complex 2, sigma 1 subunit-HPRD12086608 
ARRB1ARB1 | ARR1arrestin, beta 1-HPRD11777907 
ARRB2ARB2 | ARR2 | BARR2 | DKFZp686L0365arrestin, beta 2Reconstituted Complex
Two-hybrid		BioGRID10097102 |12070169 
ATMAT1 | ATA | ATC | ATD | ATDC | ATE | DKFZp781A0353 | MGC74674 | TEL1 | TELO1ataxia telangiectasia mutated-HPRD9707615 
ATP6V1G1ATP6G | ATP6G1 | ATP6GL | ATP6J | DKFZp547P234 | Vma10ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1Two-hybridBioGRID16189514 
BUB1BBUB1beta | BUBR1 | Bub1A | MAD3L | SSK1 | hBUBR1budding uninhibited by benzimidazoles 1 homolog beta (yeast)-HPRD,BioGRID12419313 
CLINT1CLINT | ENTH | EPN4 | EPNR | EPSINR | FLJ46753 | KIAA0171clathrin interactor 1-HPRD,BioGRID12429846 
DHX58D11LGP2 | D11lgp2e | LGP2DEXH (Asp-Glu-X-His) box polypeptide 58Two-hybridBioGRID16189514 
FAM46CFLJ20202family with sequence similarity 46, member CTwo-hybridBioGRID16189514 
KIAA0408FLJ43995 | RP3-403A15.2KIAA0408Two-hybridBioGRID16189514 
LDLRAP1ARH | ARH1 | ARH2 | DKFZp586D0624 | FHCB1 | FHCB2 | MGC34705low density lipoprotein receptor adaptor protein 1Reconstituted Complex
Two-hybrid		BioGRID12221107 |16189514 
MEA1HYS | MEAmale-enhanced antigen 1Affinity Capture-Western
Two-hybrid		BioGRID16189514 
MLH1COCA2 | FCC2 | HNPCC | HNPCC2 | MGC5172 | hMLH1mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)Two-hybridBioGRID16189514 
NECAP2FLJ10420 | RP4-798A10.1NECAP endocytosis associated 2Two-hybridBioGRID16189514 
NUP54MGC13407nucleoporin 54kDaTwo-hybridBioGRID16189514 
POM121DKFZp586G1822 | DKFZp586P2220 | FLJ41820 | KIAA0618 | MGC3792 | POM121APOM121 membrane glycoprotein (rat)Two-hybridBioGRID16189514 
RIBC2C22orf11RIB43A domain with coiled-coils 2Two-hybridBioGRID16189514 
RNPS1E5.1 | MGC117332RNA binding protein S1, serine-rich domainAffinity Capture-MSBioGRID17353931 
TERF2IPDRIP5 | RAP1telomeric repeat binding factor 2, interacting proteinTwo-hybridBioGRID16189514 
TGFBR1AAT5 | ACVRLK4 | ALK-5 | ALK5 | LDS1A | LDS2A | SKR4 | TGFR-1transforming growth factor, beta receptor 1-HPRD,BioGRID12429842 
TGFBR2AAT3 | FAA3 | LDS1B | LDS2B | MFS2 | RIIC | TAAD2 | TGFR-2 | TGFbeta-RIItransforming growth factor, beta receptor II (70/80kDa)Affinity Capture-Western
Two-hybrid		BioGRID12429842 
THAP1FLJ10477 | MGC33014THAP domain containing, apoptosis associated protein 1Two-hybridBioGRID16189514 
TUBGCP476P | FLJ14797 | GCP4tubulin, gamma complex associated protein 4Two-hybridBioGRID16189514 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-143204920561A,m8hsa-miR-143brainUGAGAUGAAGCACUGUAGCUCA
miR-203.13343401Ahsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-30-3p384390m8hsa-miR-30a-3pCUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3pCUUUCAGUCGGAUGUUUACAGC
miR-5443443501Ahsa-miR-544AUUCUGCAUUUUUAGCAAGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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