Gene Page: DCT

Summary
GeneID  1638
Symbol  DCT
Synonyms  TYRP2
Description  dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)
See related  HGNC:2709|MIM:191275|Ensembl:ENSG00000080166|HPRD:01864|
Locus tag  -
Gene type  protein-coding
Map location  13q32
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
B4GALT30.940.93
DEDD0.940.92
COG40.940.92
PSMD30.940.94
YIPF30.930.93
ZNF2070.930.92
STX50.930.93
KIAA11910.930.92
SEC130.930.92
ACTR1A0.930.91
Top 10 negatively co-expressed genes
MT-CO2-0.78-0.84
AF347015.31-0.76-0.82
AF347015.33-0.76-0.84
AF347015.8-0.76-0.84
AF347015.27-0.75-0.84
MT-CYB-0.75-0.83
AF347015.2-0.73-0.84
AF347015.26-0.73-0.83
AF347015.15-0.72-0.81
AF347015.21-0.70-0.83
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004167dopachrome isomerase activityISS-
GO:0004167dopachrome isomerase activityNAS8148378 
GO:0005507copper ion bindingTAS8206391 
GO:0016853isomerase activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0016491oxidoreductase activityIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008544epidermis developmentTAS8206391 
GO:0048468cell developmentIEA-
GO:0048066pigmentation during developmentIEA-
GO:0008152metabolic processIEA-
GO:0006582melanin metabolic processNAS-
GO:0006583melanin biosynthetic process from tyrosineISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005792microsomeISS-
GO:0005829cytosolISS-
GO:0005575cellular_componentND-
GO:0016020membraneIEA-
GO:0016021integral to membraneTAS8206391 
GO:0033162melanosome membraneIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
DCTTYRP2dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)-HPRD,BioGRID9356298 |10079069 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_TYROSINE_METABOLISM 4230All SZGR genes in this pathway
KEGG_MELANOGENESIS 10280All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN 526357All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_UP 584356All SZGR genes in this pathway
HERNANDEZ_ABERRANT_MITOSIS_BY_DOCETACEL_2NM_UP 8157All SZGR genes in this pathway
HERNANDEZ_MITOTIC_ARREST_BY_DOCETAXEL_2_UP 6445All SZGR genes in this pathway
AMUNDSON_GENOTOXIC_SIGNATURE 10568All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM4 261153All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_DN 357212All SZGR genes in this pathway
SAKAI_TUMOR_INFILTRATING_MONOCYTES_DN 8151All SZGR genes in this pathway
LEE_LIVER_CANCER_MYC_TGFA_DN 6544All SZGR genes in this pathway
LEE_LIVER_CANCER_MYC_E2F1_DN 6438All SZGR genes in this pathway
LEE_LIVER_CANCER_MYC_DN 6340All SZGR genes in this pathway
DORSAM_HOXA9_TARGETS_DN 3222All SZGR genes in this pathway
LEE_LIVER_CANCER_E2F1_DN 6442All SZGR genes in this pathway
MARIADASON_REGULATED_BY_HISTONE_ACETYLATION_DN 5430All SZGR genes in this pathway
LINDVALL_IMMORTALIZED_BY_TERT_DN 8056All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_GAMMA_RADIATION 8159All SZGR genes in this pathway
KYNG_DNA_DAMAGE_UP 226164All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_DN 543317All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN 593372All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_DN 591366All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_DN 270181All SZGR genes in this pathway
LABBE_WNT3A_TARGETS_DN 9753All SZGR genes in this pathway
POOLA_INVASIVE_BREAST_CANCER_DN 13483All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_AND_SATB1_UP 8752All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
SERVITJA_ISLET_HNF1A_TARGETS_DN 10971All SZGR genes in this pathway
SERVITJA_LIVER_HNF1A_TARGETS_DN 157105All SZGR genes in this pathway
RATTENBACHER_BOUND_BY_CELF1 467251All SZGR genes in this pathway


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