Gene Page: DLAT

Summary
GeneID  1737
Symbol  DLAT
Synonyms  DLTA|PDC-E2|PDCE2
Description  dihydrolipoamide S-acetyltransferase
See related  HGNC:2896|MIM:608770|Ensembl:ENSG00000150768|HPRD:10578|
Locus tag  -
Gene type  protein-coding
Map location  11q23.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.006 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
DLX10.960.90
DLX20.960.90
SP90.930.90
AC018470.30.920.90
ARX0.910.88
SOX10.850.76
AC117395.40.830.70
MYO3A0.820.48
AKNA0.820.58
POU3F40.810.67
Top 10 negatively co-expressed genes
AF347015.31-0.31-0.69
C5orf53-0.30-0.57
S100B-0.30-0.65
PTGDS-0.30-0.57
PTH1R-0.30-0.51
MT-CO2-0.30-0.70
AF347015.27-0.30-0.68
HLA-F-0.30-0.56
TINAGL1-0.30-0.54
ALDOC-0.30-0.52
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIEA-
GO:0005524ATP bindingIEA-
GO:0004812aminoacyl-tRNA ligase activityIEA-
GO:0004742dihydrolipoyllysine-residue acetyltransferase activityNAS3191998 
GO:0016740transferase activityIEA-
GO:0008415acyltransferase activityIEA-
GO:0031405lipoic acid bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006418tRNA aminoacylation for protein translationIEA-
GO:0006096glycolysisIEA-
GO:0006090pyruvate metabolic processIEA-
GO:0006085acetyl-CoA biosynthetic processNAS-
GO:0008152metabolic processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIEA-
GO:0005739mitochondrionIEA-
GO:0005967mitochondrial pyruvate dehydrogenase complexNAS3191998 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
DLDDLDH | E3 | GCSL | LAD | PHE3dihydrolipoamide dehydrogenase-HPRD14638692 
PDHA1PDHA | PDHCE1A | PHE1Apyruvate dehydrogenase (lipoamide) alpha 1-HPRD14638692 
PDHBDKFZp564K0164 | PHE1Bpyruvate dehydrogenase (lipoamide) beta-HPRD,BioGRID14638692 
PDHXDLDBP | E3BP | OPDX | PDX1 | proXpyruvate dehydrogenase complex, component X-HPRD,BioGRID14638692 
PDK1-pyruvate dehydrogenase kinase, isozyme 1-HPRD,BioGRID11978179 
PDK2PDHK2pyruvate dehydrogenase kinase, isozyme 2-HPRD,BioGRID12816949 
PDK3-pyruvate dehydrogenase kinase, isozyme 3-HPRD,BioGRID11978179 
PDK4FLJ40832pyruvate dehydrogenase kinase, isozyme 4-HPRD11978179 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_GLYCOLYSIS_GLUCONEOGENESIS 6241All SZGR genes in this pathway
KEGG_CITRATE_CYCLE_TCA_CYCLE 3223All SZGR genes in this pathway
KEGG_PYRUVATE_METABOLISM 4026All SZGR genes in this pathway
REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE 4832All SZGR genes in this pathway
REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT 14185All SZGR genes in this pathway
REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX 139All SZGR genes in this pathway
REACTOME_PYRUVATE_METABOLISM 1914All SZGR genes in this pathway
LIU_SOX4_TARGETS_DN 309191All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN 320184All SZGR genes in this pathway
HORIUCHI_WTAP_TARGETS_DN 310188All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_MONOCYTE_UP 204140All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_3_4WK_UP 214144All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_4_5WK_DN 196131All SZGR genes in this pathway
MCBRYAN_PUBERTAL_TGFB1_TARGETS_UP 169127All SZGR genes in this pathway
LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN 800473All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP 358245All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
MANALO_HYPOXIA_DN 289166All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
WANG_TARGETS_OF_MLL_CBP_FUSION_DN 4531All SZGR genes in this pathway
KUMAR_TARGETS_OF_MLL_AF9_FUSION 405264All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR 532309All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_DN 371218All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_NO_BLOOD_DN 15093All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_DN 14588All SZGR genes in this pathway
BURTON_ADIPOGENESIS_6 189112All SZGR genes in this pathway
STEIN_ESRRA_TARGETS_UP 388234All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BONE_DN 315197All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP 648398All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING 510309All SZGR genes in this pathway
ZHANG_BREAST_CANCER_PROGENITORS_UP 425253All SZGR genes in this pathway
MOOTHA_HUMAN_MITODB_6_2002 429260All SZGR genes in this pathway
MOOTHA_MITOCHONDRIA 447277All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
STEIN_ESRRA_TARGETS 535325All SZGR genes in this pathway
WONG_EMBRYONIC_STEM_CELL_CORE 335193All SZGR genes in this pathway
KARLSSON_TGFB1_TARGETS_UP 12778All SZGR genes in this pathway
GREGORY_SYNTHETIC_LETHAL_WITH_IMATINIB 14583All SZGR genes in this pathway
LU_EZH2_TARGETS_DN 414237All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway
LEE_BMP2_TARGETS_DN 882538All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1829449501Ahsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-969439501A,m8hsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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