Gene Page: DNM2

Summary
GeneID  1785
Symbol  DNM2
Synonyms  CMTDI1|CMTDIB|DI-CMTB|DYN2|DYNII
Description  dynamin 2
See related  HGNC:2974|MIM:602378|Ensembl:ENSG00000079805|HPRD:03852|
Locus tag  -
Gene type  protein-coding
Map location  19p13.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 11.4542 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
RFNG0.850.87
CHKB0.840.81
TRMT2A0.840.86
FAM113A0.840.86
CDK100.830.84
RHOT20.830.85
IFRD20.810.79
TTLL30.810.79
RP3-402G11.10.810.83
AUP10.800.80
Top 10 negatively co-expressed genes
MT-ATP8-0.51-0.50
AF347015.2-0.51-0.45
AF347015.8-0.50-0.44
AF347015.31-0.50-0.44
MT-CYB-0.49-0.43
AF347015.15-0.49-0.42
AF347015.18-0.48-0.46
AF347015.26-0.48-0.43
MT-CO2-0.48-0.41
AF347015.27-0.48-0.44
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003774motor activityIEA-
GO:0003924GTPase activityIEA-
GO:0003924GTPase activityNAS11583995 
GO:0005525GTP bindingIEA-
GO:0005525GTP bindingNAS7590285 
GO:0016787hydrolase activityIEA-
GO:0008017microtubule bindingNAS7590285 
GO:0016563transcription activator activityNAS10893263 
GO:0019899enzyme bindingNAS11583995 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0048489synaptic vesicle transportNASneuron, Synap (GO term level: 6)11583995 
GO:0000086G2/M transition of mitotic cell cycleNAS7590285 
GO:0007165signal transductionNAS10893263 
GO:0006897endocytosisNAS10101292 |11583995 
GO:0043065positive regulation of apoptosisNAS10893263 
GO:0045449regulation of transcriptionNAS10893263 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0045211postsynaptic membraneIDASynap, Neurotransmitter (GO term level: 5)11583995 
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0005856cytoskeletonIEA-
GO:0005874microtubuleIEA-
GO:0005737cytoplasmNAS-
GO:0005886plasma membraneIEA-
GO:0030054cell junctionIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABI1ABI-1 | E3B1 | NAP1BP | SSH3BP | SSH3BP1abl-interactor 1An unspecified isoform of Dyn2 interacts with Abi-1. This interaction was modeled on a demonstrated interaction between human Dyn2 and Abi-1 from an unspecified species.BIND15696170 
ABP1ABP | AOC1 | DAO | DAO1 | KAOamiloride binding protein 1 (amine oxidase (copper-containing))-HPRD12419186 
BAT1D6S81E | DDX39B | UAP56HLA-B associated transcript 1Two-hybridBioGRID16169070 
CDC2CDC28A | CDK1 | DKFZp686L20222 | MGC111195cell division cycle 2, G1 to S and G2 to M-HPRD7590285 
CRKL-v-crk sarcoma virus CT10 oncogene homolog (avian)-likeAn unspecified isoform of Dyn2 interacts with CrkL. This interaction was modeled on a demonstrated interaction between human Dyn2 and CrkL from an unspecified species.BIND15696170 
CTTNEMS1 | FLJ34459cortactin-HPRD12419186 
DYNLL1DLC1 | DLC8 | DNCL1 | DNCLC1 | LC8 | LC8a | MGC126137 | MGC126138 | PIN | hdlc1dynein, light chain, LC8-type 1-HPRD14760703 
EPS15AF-1P | AF1P | MLLT5epidermal growth factor receptor pathway substrate 15-HPRD,BioGRID11483962 
FERTYK3fer (fps/fes related) tyrosine kinaseCo-fractionationBioGRID9722593 
GRAP2GADS | GRAP-2 | GRB2L | GRBLG | GRID | GRPL | GrbX | Grf40 | Mona | P38GRB2-related adaptor protein 2An unspecified isoform of Dyn2 interacts with Gads. This interaction was modeled on a demonstrated interaction between human Dyn2 and Gads from an unspecified species.BIND15696170 
LCKYT16 | p56lck | pp58lcklymphocyte-specific protein tyrosine kinaseAn unspecified isoform of Dyn2 interacts with Lck. This interaction was modeled on a demonstrated interaction between human Dyn2 and Lck from an unspecified species.BIND15696170 
MPHOSPH6MPP | MPP-6 | MPP6M-phase phosphoprotein 6-HPRD15231747 
MPP6PALS2 | VAM-1 | VAM1 | p55Tmembrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)-HPRD,BioGRID15231747 
NCK1MGC12668 | NCK | NCKalphaNCK adaptor protein 1An unspecified isoform of Dyn2 interacts with Nck. This interaction was modeled on a demonstrated interaction between human Dyn2 and Nck from an unspecified species.BIND15696170 
PDE6GDKFZp686C0587 | MGC125749 | PDEGphosphodiesterase 6G, cGMP-specific, rod, gamma-HPRD11502744 
Reconstituted ComplexBioGRID12624098 
PFN1-profilin 1-HPRD12419186 
PTK2FADK | FAK | FAK1 | pp125FAKPTK2 protein tyrosine kinase 2PTK2 (FAK) interacts with DNM2 (DYN2).BIND15895076 
SH3GLB1Bif-1 | CGI-61 | KIAA0491 | dJ612B15.2SH3-domain GRB2-like endophilin B1-HPRD12456676 
SHANK1SPANK-1 | SSTRIP | synamonSH3 and multiple ankyrin repeat domains 1-HPRD,BioGRID11583995 
SHANK2CORTBP1 | CTTNBP1 | ProSAP1 | SHANK | SPANK-3SH3 and multiple ankyrin repeat domains 2-HPRD,BioGRID11583995 
SNX9MST155 | MSTP155 | SDP1 | SH3PX1 | SH3PXD3A | WISPsorting nexin 9Affinity Capture-MS
Affinity Capture-Western		BioGRID12952949 
VAV1VAVvav 1 guanine nucleotide exchange factorAn unspecified isoform of Dyn2 interacts with Vav1.BIND15696170 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124/506571577m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-130/301224230m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-1339096m8hsa-miR-133aUUGGUCCCCUUCAACCAGCUGU
hsa-miR-133bUUGGUCCCCUUCAACCAGCUA
miR-17-5p/20/93.mr/106/519.d226232m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-204/2118368431A,m8hsa-miR-204brainUUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211UUCCCUUUGUCAUCCUUCGCCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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