Gene Page: DOK1

Summary
GeneID  1796
Symbol  DOK1
Synonyms  MGC117395|MGC138860|P62DOK
Description  docking protein 1, 62kDa (downstream of tyrosine kinase 1)
See related  HGNC:2990|MIM:602919|Ensembl:ENSG00000115325|HPRD:04228|
Locus tag  -
Gene type  protein-coding
Map location  2p13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0078 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
FASN0.940.93
DTX40.930.94
RUSC10.930.93
MTMR40.930.95
FAM161B0.920.95
PACS10.920.91
ZMYM30.920.95
SREBF20.920.95
RALGPS10.920.94
CDK5R10.920.93
Top 10 negatively co-expressed genes
AF347015.31-0.75-0.88
MT-CO2-0.73-0.88
AF347015.27-0.72-0.85
AF347015.33-0.70-0.82
AF347015.8-0.70-0.86
MT-CYB-0.70-0.83
C5orf53-0.70-0.74
IFI27-0.70-0.83
FXYD1-0.70-0.82
S100B-0.70-0.80
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005066transmembrane receptor protein tyrosine kinase signaling protein activityIEA-
GO:0005158insulin receptor bindingIEA-
GO:0005515protein bindingTAS10799545 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayTAS9008160 
GO:0007265Ras protein signal transductionIEA-
GO:0007243protein kinase cascadeIEA-
GO:0007166cell surface receptor linked signal transductionTAS10799545 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinase-HPRD10567556 
Affinity Capture-Western
Biochemical Activity
Reconstituted Complex		BioGRID9008161 |11071635 
CRKL-v-crk sarcoma virus CT10 oncogene homolog (avian)-like-HPRD,BioGRID11071635 
DOK1MGC117395 | MGC138860 | P62DOKdocking protein 1, 62kDa (downstream of tyrosine kinase 1)Affinity Capture-WesternBioGRID11825908 
DOK2p56DOK | p56dok-2docking protein 2, 56kDaAffinity Capture-WesternBioGRID10822173 
FGRFLJ43153 | MGC75096 | SRC2 | c-fgr | c-src2 | p55c-fgr | p58c-fgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homologReconstituted ComplexBioGRID11071635 
HCKJTK9hemopoietic cell kinaseReconstituted ComplexBioGRID11071635 
INPP5DMGC104855 | MGC142140 | MGC142142 | SHIP | SHIP1 | SIP-145 | hp51CNinositol polyphosphate-5-phosphatase, 145kDaAffinity Capture-Western
Reconstituted Complex		BioGRID10822173 |11071635 
SHIP1 interacts with DOK1BIND10822173 
KITC-Kit | CD117 | PBT | SCFRv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog-HPRD,BioGRID11825908 
LYNFLJ26625 | JTK8v-yes-1 Yamaguchi sarcoma viral related oncogene homologBiochemical Activity
Reconstituted Complex		BioGRID11071635 |11825908 
MAP4K4FLH21957 | FLJ10410 | FLJ20373 | FLJ90111 | HGK | KIAA0687 | NIKmitogen-activated protein kinase kinase kinase kinase 4-HPRD10669731 
NCK1MGC12668 | NCK | NCKalphaNCK adaptor protein 1-HPRD12087092 
NCK2GRB4 | NCKbetaNCK adaptor protein 2-HPRD,BioGRID9737977 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)Reconstituted ComplexBioGRID11071635 
PLCG1PLC-II | PLC1 | PLC148 | PLCgamma1phospholipase C, gamma 1Reconstituted ComplexBioGRID11071635 
PTPN6HCP | HCPH | HPTP1C | PTP-1C | SH-PTP1 | SHP-1 | SHP-1L | SHP1protein tyrosine phosphatase, non-receptor type 6-HPRD10585470 
PTPRHFLJ39938 | MGC133058 | MGC133059 | SAP-1protein tyrosine phosphatase, receptor type, H-HPRD11278335 
RASA1CM-AVM | CMAVM | DKFZp434N071 | GAP | PKWS | RASA | RASGAP | p120GAP | p120RASGAPRAS p21 protein activator (GTPase activating protein) 1-HPRD,BioGRID9008161 
DOK1 interacts with RASGAPBIND10822173 
RETCDHF12 | HSCR1 | MEN2A | MEN2B | MTC1 | PTC | RET-ELE1 | RET51ret proto-oncogene-HPRD,BioGRID12087092 
SH2D1ADSHP | EBVS | FLJ18687 | FLJ92177 | IMD5 | LYP | MTCP1 | SAP | XLP | XLPDSH2 domain protein 1A-HPRD,BioGRID10852966 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1Affinity Capture-WesternBioGRID10822173 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)Reconstituted ComplexBioGRID11071635 
TECMGC126760 | MGC126762 | PSCTK4tec protein tyrosine kinaseAffinity Capture-Western
Biochemical Activity
Reconstituted Complex		BioGRID11071635 |11825908 
YES1HsT441 | P61-YES | Yes | c-yesv-yes-1 Yamaguchi sarcoma viral oncogene homolog 1Reconstituted ComplexBioGRID11071635 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-133122128m8hsa-miR-133aUUGGUCCCCUUCAACCAGCUGU
hsa-miR-133bUUGGUCCCCUUCAACCAGCUA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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