Gene Page: DPYSL2

Summary
GeneID  1808
Symbol  DPYSL2
Synonyms  CRMP2|DHPRP2|DRP-2|DRP2
Description  dihydropyrimidinase-like 2
See related  HGNC:3014|MIM:602463|Ensembl:ENSG00000092964|HPRD:03914|
Locus tag  -
Gene type  protein-coding
Map location  8p22-p21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
GSMA_Igenome scan meta-analysisPsr: 0.031 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.03086 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.00057 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 4 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ZC3H180.830.85
PHRF10.830.84
AXIN10.820.84
ELAVL30.820.82
SART10.820.83
AZI10.810.83
AD000671.10.810.85
MLLT10.810.82
ZC3H40.810.85
ZNF6460.810.85
Top 10 negatively co-expressed genes
C5orf53-0.63-0.69
AF347015.31-0.61-0.73
B2M-0.61-0.70
MT-CO2-0.58-0.70
IFI27-0.57-0.67
AF347015.27-0.57-0.69
HIGD1B-0.57-0.70
S100B-0.56-0.64
COPZ2-0.56-0.64
MYL3-0.56-0.69
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004157dihydropyrimidinase activityTAS8973361 
GO:0005515protein bindingIPI16260607 
GO:0016810hydrolase activity, acting on carbon-nitrogen (but not peptide) bondsIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007399nervous system developmentTASneurite (GO term level: 5)8973361 
GO:0006139nucleobase, nucleoside, nucleotide and nucleic acid metabolic processTAS8973361 
GO:0007165signal transductionTAS8973361 
GO:0007275multicellular organismal developmentIEA-
GO:0030154cell differentiationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0043025cell somaIEAaxon, dendrite (GO term level: 4)-
GO:0030425dendriteIEAneuron, axon, dendrite (GO term level: 6)-
GO:0030424axonIEAneuron, axon, Neurotransmitter (GO term level: 6)-
GO:0005856cytoskeletonIDA18029348 
GO:0005737cytoplasmIEA-
GO:0005739mitochondrionIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AP2A1ADTAA | AP2-ALPHA | CLAPA1adaptor-related protein complex 2, alpha 1 subunitAffinity Capture-Western
Reconstituted Complex		BioGRID12942088 
CRMP1DPYSL1 | DRP-1 | DRP1collapsin response mediator protein 1-HPRD,BioGRID12482610 
DPYSL5CRAM | CRMP-5 | CRMP5 | FLJ45383 | Ulip6dihydropyrimidinase-like 5-HPRD10956643 
NUMBS171numb homolog (Drosophila)-HPRD,BioGRID11121447 |12942088 
RHOAARH12 | ARHA | RHO12 | RHOH12ras homolog gene family, member APhenotypic SuppressionBioGRID12482610 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_AXON_GUIDANCE 129103All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE 251188All SZGR genes in this pathway
REACTOME_CRMPS_IN_SEMA3A_SIGNALING 1414All SZGR genes in this pathway
REACTOME_SEMAPHORIN_INTERACTIONS 6853All SZGR genes in this pathway
REACTOME_L1CAM_INTERACTIONS 8662All SZGR genes in this pathway
REACTOME_RECYCLING_PATHWAY_OF_L1 2715All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_UP 201125All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN 526357All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_UP 294178All SZGR genes in this pathway
HUTTMANN_B_CLL_POOR_SURVIVAL_UP 276187All SZGR genes in this pathway
LIU_VMYB_TARGETS_UP 12778All SZGR genes in this pathway
LAIHO_COLORECTAL_CANCER_SERRATED_UP 11271All SZGR genes in this pathway
RHEIN_ALL_GLUCOCORTICOID_THERAPY_DN 362238All SZGR genes in this pathway
KIM_WT1_TARGETS_DN 459276All SZGR genes in this pathway
ELVIDGE_HYPOXIA_UP 171112All SZGR genes in this pathway
ELVIDGE_HIF1A_AND_HIF2A_TARGETS_DN 10472All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2A_DN 14184All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2B 392251All SZGR genes in this pathway
MATTIOLI_MULTIPLE_MYELOMA_WITH_14Q32_TRANSLOCATIONS 3625All SZGR genes in this pathway
HERNANDEZ_MITOTIC_ARREST_BY_DOCETAXEL_1_DN 3823All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_2FC_UP 147All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP 479299All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN 514330All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
BENPORATH_OCT4_TARGETS 290172All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS 734436All SZGR genes in this pathway
BENPORATH_NOS_TARGETS 179105All SZGR genes in this pathway
KENNY_CTNNB1_TARGETS_DN 5234All SZGR genes in this pathway
PENG_GLUCOSE_DEPRIVATION_DN 169112All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
ZHANG_TARGETS_OF_EWSR1_FLI1_FUSION 8868All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_MF_UP 4727All SZGR genes in this pathway
VERHAAK_AML_WITH_NPM1_MUTATED_DN 246180All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_DN 4127All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
DELASERNA_MYOD_TARGETS_DN 5742All SZGR genes in this pathway
LEE_AGING_CEREBELLUM_DN 8666All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_DN 287208All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN 911527All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP 783442All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
TOOKER_GEMCITABINE_RESISTANCE_DN 12284All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP 338225All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_DN 235144All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_DN 245150All SZGR genes in this pathway
CHANG_CORE_SERUM_RESPONSE_DN 209137All SZGR genes in this pathway
VALK_AML_CLUSTER_11 3624All SZGR genes in this pathway
WOO_LIVER_CANCER_RECURRENCE_UP 10575All SZGR genes in this pathway
YAGI_AML_WITH_T_8_21_TRANSLOCATION 368247All SZGR genes in this pathway
WINNEPENNINCKX_MELANOMA_METASTASIS_DN 4626All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S1 237159All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
HIRSCH_CELLULAR_TRANSFORMATION_SIGNATURE_DN 10367All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_UP 259159All SZGR genes in this pathway
PASINI_SUZ12_TARGETS_DN 315215All SZGR genes in this pathway
IKEDA_MIR30_TARGETS_UP 11687All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN 784464All SZGR genes in this pathway
LIM_MAMMARY_LUMINAL_MATURE_DN 9974All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-130/30118651871m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-145534540m8hsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
miR-17-5p/20/93.mr/106/519.d18671873m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-18121482154m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-22422072213m8hsa-miR-224CAAGUCACUAGUGGUUCCGUUUA
miR-2999710041A,m8hsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
miR-30-5p21122118m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-329231823241Ahsa-miR-329brainAACACACCUGGUUAACCUCUUU
miR-409-5p234823541Ahsa-miR-409-5pAGGUUACCCGAGCAACUUUGCA
miR-41024232429m8hsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-494246324691Ahsa-miR-494brainUGAAACAUACACGGGAAACCUCUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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